Administrative Core

行政核心

基本信息

批准号：
10186764
负责人：
JANOS ZEMPLENI
金额：
$ 76.6万
依托单位：
UNIVERSITY OF NEBRASKA LINCOLN
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-05 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10186764
关键词：
Address Advisory Committees Agriculture American Heart Association Award Basic Science Bioinformatics Biological Biomedical Research Biometry Center for Translational Science Activities Centers of Research Excellence Clinical Clinical Research Collaborations Data Analyses Development Development Plans Disease Ensure Equipment Europe Evaluation Event Experimental Designs Faculty Fostering Foundations Funding Goals Grant Health Incentives Individual Infrastructure Institution Interdisciplinary Study Lead Leadership Medical center Mentors Metabolic National Institute of Diabetes and Digestive and Kidney Diseases Nebraska Nutritional Study Obesity Obesity Epidemic Obesity associated disease Peer Review Phase Play Positioning Attribute Publications Publishing Research Research Infrastructure Research Personnel Research Project Grants Research Support Resource Sharing Resources Role S Phase Secure Seeds Services Signal Transduction Strategic Planning Supercomputing Translational Research Travel United States National Institutes of Health Universities Vision Visit cohort combat community based participatory research computerized data processing data acquisition dietary equipment acquisition foodborne improved member multidisciplinary nutrition nutritional genomics obesity prevention prevent professor programs recruit square foot statistics success

项目摘要

The Nebraska Center for the Prevention of Obesity Diseases through Dietary Molecules (NPOD) at the University of Nebraska supports research on the identification of biological, mainly food-borne, signals that prevent, treat, and cure obesity and obesity-related diseases. NPOD, a Center of Biomedical Research Excellence (COBRE), is guided by the overarching goals to strengthen the metabolic, obesity, and nutrition research infrastructure in Nebraska and enhance the ability of NPOD investigators to compete for external research funding – all while making significant research contributions to combatting the national obesity epidemic. Critical to NPOD's ability to operate effectively and efficiently is a strong Administrative Core that provides the programmatic leadership, administrative support, and infrastructure necessary to ensure the center is successful. Importantly, the Administrative Core will maintain continuity in its leadership and the membership of its external and internal advisory committees during COBRE Phase 2. During Phase 1, the Administrative Core played an instrumental role in NPOD success as evidenced by several key metrics. NPOD junior investigators published 154 peer- reviewed publications and secured approximately $31M in research dollars, including 11 major research grants from NIH (three R01, one R21, one R35), the U.S. Department of Agriculture (three), the American Heart Association (two), and the Bill and Melinda Gates Foundation. Center membership grew to 51 multidisciplinary investigators in 16 units with over $96M in external research funding. The Administrative Core secured additional space and equipment for NPOD's Research Core and will play a key role in the center's Phase 2 success by leveraging NIH funding and institutional commitments for five new faculty positions in four departments (plus a UNL Program of Excellence hire in nutrigenomics), approximately $1.2M toward start-up packages, and over $1M in cash matches in support of pilot, seed, and revision grant programs, mentor incentives, and equipment purchases. The Administrative Core will leverage these commitments and Phase 1 successes to 1) increase the critical mass of center investigators conducting multidisciplinary research through new hires, pilot and seed grants, and facilitate the submission of large-scale proposals through providing P01 (or RM1) pilot grant funding; 2) facilitate the transition of junior investigators to independent investigator status by providing honoraria for external and internal mentors, support for individual development plans with milestones, formative and summative evaluations, and networking opportunities via travel support and a visiting professors program; 3) support the success of the Biomedical and Obesity Research Core by coordinating services in experimental design, large data processing, and biostatistics and bioinformatics analyses and facilitating the acquisition of equipment with institutional commitments for five new equipment additions planned in Phase 2; and 4) broaden the scope of center research to include clinical and translational research by recruiting a new hire and considering nine in a pipeline of 21 candidates for project leader slots who have a focus on clinical and translational research.

内布拉斯加州大学通过膳食分子预防肥胖病中心 (NPOD) 内布拉斯加州支持识别生物信号（主要是食源性信号）的研究，这些信号可预防、治疗、并治疗肥胖和肥胖相关疾病 NPOD，卓越生物医学研究中心 (COBRE)，以加强代谢、肥胖和营养研究基础设施的总体目标为指导内布拉斯加州并增强 NPOD 研究人员竞争外部研究经费的能力 – 同时为抗击全国肥胖流行病做出重大研究贡献，这对 NPOD 的能力至关重要。有效和高效地运作是一个强大的行政核心，它提供了计划性的领导，确保中心成功所需的行政支持和基础设施。行政核心将保持其领导力及其外部和内部成员的连续性 COBRE 第 2 阶段期间的咨询委员会。在第 1 阶段期间，行政核心发挥了重要作用 NPOD 初级研究人员发表的 154 项同行研究成果证明了其在 NPOD 成功中的作用。审阅出版物并获得约 3100 万美元的研究经费，其中包括 11 项重大研究资助来自 NIH（三个 R01、一个 R21、一个 R35）、美国农业部（三个）、美国心脏协会协会（两个），以及比尔和梅琳达·盖茨基金会中心的多学科会员数量增加到 51 个。 16 个单位的研究人员获得了超过 9600 万美元的外部研究经费。为 NPOD 的研究核心提供空间和设备，并将在该中心第二阶段的成功中发挥关键作用利用 NIH 的资金和机构承诺在四个系（加上一个 UNL 营养基因组学卓越招聘计划），大约 120 万美元用于启动套餐，及以上 100 万美元现金匹配，用于支持试点、种子和修订资助计划、导师激励和设备行政核心将利用这些承诺和第一阶段的成功来 1) 增加采购。通过新员工、试点和种子进行多学科研究的中心研究人员数量达到临界值赠款，并通过提供 P01（或 RM1）试点赠款资金促进大规模提案的提交； 2) 通过向初级研究者提供酬金，促进初级研究者向独立研究者的过渡外部和内部导师，支持个人发展计划的里程碑、形成性和总结性评估、通过旅行支持和客座教授计划建立的交流机会；3) 通过协调实验服务来支持生物医学和肥胖研究核心的成功设计、大数据处理、生物统计学和生物信息学分析，并促进获取机构承诺在第 2 阶段和第 4 阶段增加五种新设备；通过招募新员工并考虑，中心研究范围包括临床和转化研究项目负责人职位的 21 名候选人中有 9 名，重点关注临床和转化研究。