Graduate Training in Developmental Biology

发育生物学研究生培训

• 批准号: 10640841
• 负责人: Michael Granato
• 金额: $ 36.62万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10640841
• 关键词: Developmental Biology; Training

This is a competitive renewal for a predoctoral Training Program in developmental biology at the University of Pennsylvania. The Training Program serves as a melting and cohesion point in developmental biology as it includes trainers spread across four schools within the University, and students from 8 graduate groups. The Training Program also serves as an incubator for new initiatives in graduate training that continue to be adapted by graduate groups. The program continues to take advantage of an exceptionally strong programmatic foundation in developmental biology at the University of Pennsylvania. The Training Program’s goal is to provide broad-based training that uses state of the art technologies towards the fundamental mechanisms of developmental biology using a diversity of vertebrate, invertebrate, and plant organisms. Research training areas include transcription and cell signaling that control cell differentiation, migration, organogenesis, cellular senescence, morphogenesis, pattern formation, epigenetic regulation of developmental processes, and stem cell biology. Trainees receive formal instruction in an established curriculum of study, including lecture courses in developmental biology and advanced seminars on genetic, cellular, and molecular approaches to developmental mechanisms and disease. Students also participate in developmental biology journal clubs, a developmental biology seminar series that includes student invited speakers, research discussion groups on selected topics, and in annual scientific symposia. Trainees present their research findings at departmental seminars, local symposia and national conferences. Finally, the training program provides trainee specific activities: a) a yearly symposium to present their work in a more formal setting that includes an eminent external speaker who evaluates the training program; b) Professional development activities, such as careers in science meetings with invited speakers to discuss career options; mini-writing classes tailored to graduate students covering in depth grant and manuscript writing; a mini courses in experimental design, and training sessions with communication professionals; c) Show and Tell research days where trainees lecture other trainees about their project followed by a hands-on demonstration of research techniques employed by the trainee presenter, e.g. live cell imaging, d) lunchtime discussion with a Penn faculty of the trainee’s choice to learn about the faculty’s field of research and/or to discuss lab management or career path decisions, e) a day long visit to a pharmaceutical company to explore different aspects of working in this sector. The proposed training program requests 8 trainees per year. Trainees will be selected annually by an ad hoc trainer committee, and appointed for one year with the option for a second year pending satisfactory progress. Training outcomes will be evaluated yearly by measuring trainee publications, transitions to individual training awards, trainee surveys, an external evaluation, which all will be reviewed by an Executive Committee. Lastly, Trainers participate in a number of efforts to recruit under-represented minorities both locally and nationally.

这是针对大学发展生物学前培训计划的竞争续约 宾夕法尼亚州。培训计划是发育生物学的融化和凝聚点 包括分布在大学内四所学校中的培训师，以及来自8个研究生组的学生。 培训计划还可以作为研究生培训的新计划的孵化器 由研究生组改编。该计划继续利用一个异常强大的程序化 宾夕法尼亚大学发展生物学基金会。培训计划的目标是提供 基于广泛的培训，该培训使用艺术技术来实现 发育生物学使用多种脊椎动物，无脊椎动物和植物生物。研究培训领域 包括控制细胞分化，迁移，器官发生，细胞的转录和细胞信号传导 衰老，形态发生，模式形成，发育过程的表观遗传调节和茎 细胞生物学。学员在既定的学习课程中都会接受正式的教学，包括讲座课程 关于遗传，细胞和分子方法的发育生物学和高级半手 发育机制和疾病。学生还参加了发展生物学期刊俱乐部 发育生物学开创性系列，包括学生邀请的演讲者，研究讨论小组 选定的主题和年度科学专题讨论会。学员在部门提出了他们的研究结果 半小伙子，当地研讨会和民族会议。最后，培训计划提供了特定的学员 活动：a）每年在更正式的环境中介绍其作品的年度研讨会，其中包括杰出的 评估培训计划的外部演讲者； b）专业发展活动，例如职业 在与受邀演讲者的科学会议上讨论职业选择；为研究生量身定制的迷你写课程 深入赠款和手稿写作的学生；实验设计和培训的迷你课程 与沟通专业人士的会议； c）展示并告诉研究日，学员在哪里讲课 学员对他们的项目进行了动手演示，以展示 实习主持人，例如现场单元成像，d）午餐时间讨论与宾夕法尼亚学员的选择 了解教师的研究领域和/或讨论实验室管理或职业道路决策，e）一天 长期访问一家制药公司，探索该行业工作的不同方面。提议 培训计划每年要求8名学员。受训人员将每年由一个临时培训委员会选拔 并被任命为一年，并选择了第二年，等待满意厂的进度。培训结果 每年将通过衡量学员出版物，过渡到个人培训奖，受训者来评估 调查是一项外部评估，所有这些都将由执行委员会进行审查。最后，培训师 参加许多努力，以在当地和全国范围内招募代表性不足的少数民族。

项目成果

Two-photon live imaging of single corneal stem cells reveals compartmentalized organization of the limbal niche.

• DOI: 10.1016/j.stem.2021.02.022
• 发表时间: 2021-07-01
• 期刊: Cell stem cell
• 影响因子: 23.9
• 作者: Farrelly O;Suzuki-Horiuchi Y;Brewster M;Kuri P;Huang S;Rice G;Bae H;Xu J;Dentchev T;Lee V;Rompolas P
• 通讯作者: Rompolas P

Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures.

• DOI: 10.1016/j.ydbio.2016.03.011
• 发表时间: 2016-05-15
• 期刊: Developmental biology
• 影响因子: 2.7
• 作者: Kague E;Roy P;Asselin G;Hu G;Simonet J;Stanley A;Albertson C;Fisher S
• 通讯作者: Fisher S

PPARγ is dispensable for clear cell renal cell carcinoma progression.

• DOI: 10.1016/j.molmet.2018.05.013
• 发表时间: 2018-08
• 期刊: Molecular metabolism
• 影响因子: 8.1
• 作者: Sanchez DJ;Steger DJ;Skuli N;Bansal A;Simon MC
• 通讯作者: Simon MC

Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization.

• DOI: 10.1016/j.stem.2021.05.007
• 发表时间: 2021-09-02
• 期刊: Cell stem cell
• 影响因子: 23.9
• 作者: Huang S;Kuri P;Aubert Y;Brewster M;Li N;Farrelly O;Rice G;Bae H;Prouty S;Dentchev T;Luo W;Capell BC;Rompolas P
• 通讯作者: Rompolas P

GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment.

• DOI: 10.1016/j.cmet.2022.06.010
• 发表时间: 2022-08-02
• 期刊: CELL METABOLISM
• 影响因子: 29
• 作者: Missiaen, Rindert;Anderson, Nicole M.;Kim, Laura C.;Nance, Bailey;Burrows, Michelle;Skuli, Nicolas;Carens, Madeleine;Riscal, Romain;Steensels, An;Li, Fuming;Simon, M. Celeste
• 通讯作者: Simon, M. Celeste