Behavioral and Neural Correlates of Deficits in Naturalistic Visual and Auditory Social Cognition in Individuals at Clinical High-Risk for Schizophrenia

精神分裂症临床高危个体自然视觉和听觉社会认知缺陷的行为和神经相关性

• 批准号: 10459498
• 负责人: Gaurav H Patel
• 金额: $ 70.48万
• 依托单位: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10459498
• 关键词: Acute; Affect; Age; Anatomy; Area; Auditory; Auditory area; Behavioral; Chronic; Clinical; Clip; Cognitive; Comprehension; Cues; Data; Detection; Development; Distress; Early Intervention; Emotional; Eye Movements; Facial Expression; Failure; Functional Magnetic Resonance Imaging; Future; Goals; Heterogeneity; Human; Impairment; Individual; Infrastructure; Lead; Life; Logistics; Longitudinal Studies; Measures; Methods; Modality; Modeling; Outcome; Participant; Pathology; Pattern; Performance; Population; Psychoses; Psychotic Disorders; Resolution; Rest; Sampling; Scanning; Schizophrenia; Signal Transduction; Social Development; Social Functioning; Source; Stimulus; Structure of superior temporal sulcus; Subgroup; Symptoms; Syndrome; Techniques; Testing; Time; Visual; auditory comprehension; auditory processing; base; behavior measurement; behavioral study; clinical predictors; cognitive task; connectome; critical period; disability; emerging adult; experience; experimental study; extrastriate visual cortex; follow-up; high risk; imaging modality; innovation; movie; neural correlate; neuroimaging; neuroregulation; operation; population based; predictive modeling; psychotic symptoms; recruit; relating to nervous system; schizophrenia risk; showing emotion; social; social cognition; social deficits; social situation; stem; visual cognition; visual processing; visual search; visual tracking

Deficits in social cognition are a major source of disability and suffering in individuals at clinical high-risk for developing schizophrenia (CHR). Like schizophrenia itself, this state is associated with a high rate of social functioning deficits that have a life-long impact. However, little is known about the behavioral and neural correlates of these deficits in this population, and there are few if any treatments. In this project we will adapt techniques we developed that use naturalistic stimuli, including movie clips and spoken word stories, to measure behavioral and neural correlates of social cognition. In schizophrenia we have so far found profound deficits in the eye-movements used to visually scan naturalistic videos of social scenes for social cues (such as facial expressions of emotion) and comprehension of auditory expressions of emotion that relate to overall social cognition deficits. We have also found large functional and resting state functional connectivity deficits in the temporoparietal junction/posterior superior temporal sulcus (TPJ-pSTS), an area that serves as a hub for social cognitive operations like visual scanning. This region also fully matures in early adulthood around the age of most CHRs, suggesting that developmental failures at this age may have lasting effects. We will use a combination of behavioral, functional, and connectivity measures to examine auditory and visual social cognition in the CHRs in comparison to participants early in their psychotic illness (EPs) and demographically matched healthy controls (HCs). We will measure comprehension of short video clips of social situations, visual scanning performance, detection of auditory sarcasm, TPJ-pSTS activity evoked by both a visual only movie clip and an audio only spoken word story, and TPJ-pSTS resting state functional connectivity. The first aim will be to compare these measures between the three populations. The second aim will be to study how the eye-tracking/visual scanning and auditory sarcasm measures (and the TPJ-pSTS functional and connectivity correlates) predict social cognition at baseline and again in two years' time. The third aim will be to repeat these measures in the CHR individuals who develop schizophrenia, along with a subset of the HCs. Based on pilot results, we hypothesize that visual-related measures (visual scanning, TPJ- pSTS movie-watching activity, TPJ-pSTS connectivity) will be mildly impaired but auditory measures heightened compared to HCs, leading to overall similar social cognition at baseline, whereas in EPs will be profoundly affected in all measures. Furthermore, we hypothesize that visual scanning measures will segregate the CHRs into two groups, one similar to HCs and one similar to EPs. The latter group will be the source of most of the SzP converters, and the ones with profound deficits on repeat testing. In addition to clarifying the correlates of social cognition in this population, the impact of these experiments will be to open new avenues of early intervention on social functioning outcomes in this population based on correcting visual scanning patterns and neuromodulation of the TPJ-pSTS.

社会认知缺陷是临床高风险中个人残疾和苦难的主要来源 发展精神分裂症（CHR）。像精神分裂症本身一样，这种状态与高度社会率有关 具有终身影响的功能不足。但是，对行为和神经知之甚少 这些人群中这些缺陷的相关性，几乎没有治疗。在这个项目中，我们将适应 我们开发了使用自然主义刺激的技术，包括电影剪辑和口语故事， 测量社会认知的行为和神经相关性。在精神分裂症中，我们到目前为止发现了深刻的 用于视觉扫描社交场景的自然主义视频的眼动动物的缺陷（例如 情感的面部表情）和与整体有关的听觉表达的理解 社会认知缺陷。我们还发现了大型功能和静止状态功能连接缺陷 在颞型连接/后颞沟（TPJ-PSTS）中，该区域充当集线器 社会认知操作等视觉扫描。该地区在成年初期也完全成熟 大多数CHR的年龄，表明该年龄的发展失败可能会产生持久的影响。 我们将结合行为，功能和连接度量的组合来检查听觉和 与参与者的精神病（EPS）和参与者相比，CHR中的视觉社会认知（EPS）和 人口统计学匹配的健康对照（HCS）。我们将衡量对简短视频剪辑的理解 社交场所，视觉扫描性能，听觉讽刺的检测，TPJ-PSTS活动唤起 唯一的仅视觉电影剪辑和音频唯一的口语故事，以及tpj-pst静止状态功能 连接性。第一个目的是比较三个人群之间的这些措施。第二个目标 将研究眼睛跟踪/视觉扫描和听觉讽刺措施（以及TPJ-PSTS） 功能和连通性相关））预测基线的社会认知，并在两年内再次预测。这 第三目的是在发展精神分裂症的CHR个人中重复这些措施，以及 HCS的子集。根据试点结果，我们假设视觉相关的度量（视觉扫描，TPJ-- PSTS电影观看活动，TPJ-PSTS连接性）将受到轻度障碍，但听觉措施将受到损害 与HCS相比，增强了基线时总体相似的社会认知，而在EP中将 在所有措施中都受到深远的影响。此外，我们假设视觉扫描措施将 将CHRS分为两组，一组类似于HC，类似于EPS。后一组将是 大多数SZP转换器的来源，以及在重复测试中具有深刻缺陷的来源。此外 阐明该人群中社会认知的相关性，这些实验的影响将是开放 基于纠正视觉 TPJ-PST的扫描模式和神经调节。