Neural substrates of attention and social cognition impairment in schizophrenia

精神分裂症注意力和社会认知障碍的神经基础

基本信息

批准号：
9331745
负责人：
Gaurav H Patel
金额：
$ 19.91万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-12 至 2020-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9331745
关键词：
Area Attention Attitude Behavior Behavioral Biological Markers Brain Brain region Chronic Communication Complex Development Doctor of Philosophy Dorsal Emotional Emotions Empathy Environment Face Face Processing Facial Expression Fellowship Functional Magnetic Resonance Imaging Functional disorder Homelessness Human Image Impaired cognition Impairment Imprisonment Individual Interview Knowledge Lead Maps Measures Mediating Mental disorders Mentors Methods Mind Monitor Monkeys Morbidity - disease rate Motion Occupations Outcome Patients Pattern Perception Performance Physiology Play Population Process Program Development Research Research Domain Criteria Research Personnel Rest Risk Role Scanning Schizophrenia Social Functioning Social Perception Specific qualifier value Stimulus Structure of superior temporal sulcus Symptoms Techniques Testing Training Translating Unemployment Visual Visual Perception Visual impairment Work base behavior measurement career career development connectome design disability experimental study frontal eye fields imaging approach intraparietal sulcus mental state movie neuroimaging neuromechanism neuropsychiatric disorder neuropsychiatry novel novel strategies patient oriented research programs relating to nervous system retinotopic skills social social cognition social communication social communication impairment social situation study population theories

项目摘要

Schizophrenia (Sz) is associated with deficits in face emotion recognition (FER) that contribute directly to overall impairments in social communication and global outcome. These deficits may be related to dysfunction of face processing regions of the brain such as posterior superior temporal sulcus (pSTS). This region is also known to interact closely with the ventral attention network (VAN), which involves temporoparietal junction (TPJ) and the dorsal attention network (DAN), which involves intraparietal sulcus (IPS) and frontal eye fields (FEF). This project investigates the role of TPJ-pSTS dysfunction in mediating facial social communication impairments in Sz. The project builds directly from the candidate's prior PhD studies investigating TPJ function in humans and monkeys, as well as his more recent studies during fellowship investigating pSTS dysfunction during naturalistic scene processing in Sz. The application proposes a 4-year career development program which will permit the candidate's development into an independent investigator in patient-oriented research focusing on social communication impairments in neuropsychiatric disorders. During the project, he will work directly with mentors who are experts in the areas of perception (Drs. Javitt and Ferrera), attention (Drs. Gottlieb and Curtis), and social cognition (Dr. Ochsner), and will pursue integrated didactics and research focusing on the relationship between impairments in social communication and impairments in perception, attention and social cognition in Sz. On the neural level, the hypothesis is that these deficits will represent impaired interactions between TPJ-pSTS and other brain regions including visual perceptual regions (e.g. V1, MT), attention networks (VAN, DAN), and theory of mind networks (e.g. MFG, vmPFC). A novel feature of the project is the use of naturalistic imaging (collaborators: Drs. Hasson and Leopold) in which activation of and functional connectivity between brain regions is monitored continuously while subjects view ecologically valid stimuli (e.g. social vignettes). Human Connectome Project acquisition and processing approaches are implemented and will be used for all studies. Overall, this program will prepare me for an independent career using advanced fMRI approaches, including task-based, resting state and naturalistic fMRI, for the study of the neural basis of social communication impairments across neuropsychiatric disorders. Relevance: Impaired social communication in schizophrenia is associated with long-term disability. The present study investigates the neural bases of these deficits, and prepares the candidate for a career in studying social communication deficits in psychiatric disorders.

精神分裂症 (Sz) 与面部情绪识别 (FER) 缺陷有关，这直接导致社会沟通和全球结果的总体损害。这些缺陷可能与功能障碍有关大脑的面部处理区域，例如颞上沟（pSTS）。这个地区也是已知与腹侧注意网络（VAN）密切相互作用，该网络涉及颞顶交界处（TPJ）和背侧注意力网络（DAN），涉及顶内沟（IPS）和额叶眼区（远东基金会）。该项目研究 TPJ-pSTS 功能障碍在介导面部社交交流中的作用 Sz 的损伤。该项目直接基于候选人之前研究 TPJ 功能的博士研究在人类和猴子中进行的研究，以及他在奖学金期间调查 pSTS 功能障碍的最新研究在 Sz 的自然场景处理过程中。该申请提出了一个为期4年的职业发展计划这将使候选人发展成为以患者为导向的研究的独立研究者专注于神经精神疾病中的社交沟通障碍。项目期间，他将工作直接与感知领域专家（贾维特博士和费雷拉博士）、注意力领域专家导师（贾维特博士和费雷拉博士）进行交流。 Gottlieb 和 Curtis）和社会认知（Ochsner 博士），并将追求综合教学和研究关注社会沟通障碍和感知障碍之间的关系， Sz 的注意力和社会认知。在神经水平上，假设这些缺陷将代表 TPJ-pSTS 与其他大脑区域（包括视觉感知区域（例如 V1、 MT）、注意力网络（VAN、DAN）和心理理论网络（例如 MFG、vmPFC）。该系统的一个新颖特点是项目是使用自然成像（合作者：Hasson 博士和 Leopold 博士），其中激活和持续监测大脑区域之间的功能连接，同时受试者认为生态有效刺激（例如社交小插曲）。人类连接组项目采集和处理方法是实施并将用于所有研究。总的来说，这个项目将为我的独立职业生涯做好准备使用先进的功能磁共振成像方法，包括基于任务的、静息状态和自然功能磁共振成像，来研究跨神经精神疾病的社会沟通障碍的神经基础。相关性：精神分裂症患者的社交沟通受损与长期残疾有关。这本研究调查了这些缺陷的神经基础，并为候选人的职业生涯做好了准备研究精神疾病中的社交沟通缺陷。