Neural substrates of attention and social cognition impairment in schizophrenia
精神分裂症注意力和社会认知障碍的神经基础
基本信息
- 批准号:9331745
- 负责人:
- 金额:$ 19.91万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-12 至 2020-07-31
- 项目状态:已结题
- 来源:
- 关键词:AreaAttentionAttitudeBehaviorBehavioralBiological MarkersBrainBrain regionChronicCommunicationComplexDevelopmentDoctor of PhilosophyDorsalEmotionalEmotionsEmpathyEnvironmentFaceFace ProcessingFacial ExpressionFellowshipFunctional Magnetic Resonance ImagingFunctional disorderHomelessnessHumanImageImpaired cognitionImpairmentImprisonmentIndividualInterviewKnowledgeLeadMapsMeasuresMediatingMental disordersMentorsMethodsMindMonitorMonkeysMorbidity - disease rateMotionOccupationsOutcomePatientsPatternPerceptionPerformancePhysiologyPlayPopulationProcessProgram DevelopmentResearchResearch Domain CriteriaResearch PersonnelRestRiskRoleScanningSchizophreniaSocial FunctioningSocial PerceptionSpecific qualifier valueStimulusStructure of superior temporal sulcusSymptomsTechniquesTestingTrainingTranslatingUnemploymentVisualVisual PerceptionVisual impairmentWorkbasebehavior measurementcareercareer developmentconnectomedesigndisabilityexperimental studyfrontal eye fieldsimaging approachintraparietal sulcusmental statemovieneuroimagingneuromechanismneuropsychiatric disorderneuropsychiatrynovelnovel strategiespatient oriented researchprogramsrelating to nervous systemretinotopicskillssocialsocial cognitionsocial communicationsocial communication impairmentsocial situationstudy populationtheories
项目摘要
Schizophrenia (Sz) is associated with deficits in face emotion recognition (FER) that contribute directly to
overall impairments in social communication and global outcome. These deficits may be related to dysfunction
of face processing regions of the brain such as posterior superior temporal sulcus (pSTS). This region is also
known to interact closely with the ventral attention network (VAN), which involves temporoparietal junction
(TPJ) and the dorsal attention network (DAN), which involves intraparietal sulcus (IPS) and frontal eye fields
(FEF). This project investigates the role of TPJ-pSTS dysfunction in mediating facial social communication
impairments in Sz. The project builds directly from the candidate's prior PhD studies investigating TPJ function
in humans and monkeys, as well as his more recent studies during fellowship investigating pSTS dysfunction
during naturalistic scene processing in Sz. The application proposes a 4-year career development program
which will permit the candidate's development into an independent investigator in patient-oriented research
focusing on social communication impairments in neuropsychiatric disorders. During the project, he will work
directly with mentors who are experts in the areas of perception (Drs. Javitt and Ferrera), attention (Drs.
Gottlieb and Curtis), and social cognition (Dr. Ochsner), and will pursue integrated didactics and research
focusing on the relationship between impairments in social communication and impairments in perception,
attention and social cognition in Sz. On the neural level, the hypothesis is that these deficits will represent
impaired interactions between TPJ-pSTS and other brain regions including visual perceptual regions (e.g. V1,
MT), attention networks (VAN, DAN), and theory of mind networks (e.g. MFG, vmPFC). A novel feature of the
project is the use of naturalistic imaging (collaborators: Drs. Hasson and Leopold) in which activation of and
functional connectivity between brain regions is monitored continuously while subjects view ecologically valid
stimuli (e.g. social vignettes). Human Connectome Project acquisition and processing approaches are
implemented and will be used for all studies. Overall, this program will prepare me for an independent career
using advanced fMRI approaches, including task-based, resting state and naturalistic fMRI, for the study of the
neural basis of social communication impairments across neuropsychiatric disorders.
Relevance: Impaired social communication in schizophrenia is associated with long-term disability. The
present study investigates the neural bases of these deficits, and prepares the candidate for a career in
studying social communication deficits in psychiatric disorders.
精神分裂症(SZ)与直接促成的面部情感识别(FER)缺陷有关
社会传播和全球结果的总体损害。这些缺陷可能与功能障碍有关
大脑的面部处理区域,例如后颞沟(PSTS)。这个地区也是
已知会与腹侧连接处紧密相互作用(van)紧密相互作用
(TPJ)和背注意网络(DAN),涉及室内沟(IPS)和额叶眼场
(FEF)。该项目调查了TPJ-PST功能障碍在调解面部社会交流中的作用
SZ的障碍。该项目直接根据候选人的先前博士研究研究了TPJ功能
在人类和猴子以及他在研究金调查PST功能障碍期间的最新研究中
在SZ的自然主义场景处理中。该申请提出了一项为期4年的职业发展计划
这将允许候选人的发展成为以患者为导向的独立研究者
专注于神经精神疾病的社会沟通障碍。在项目期间,他将工作
直接与知觉领域的专家(Javitt和Ferrera博士)的指导者,注意力(Drs。
Gottlieb和Curtis)以及社会认知(Ochsner博士),并将追求综合的教学和研究
专注于社会交流中的损害与感知障碍的障碍之间的关系,
SZ的注意力和社会认知。在神经层面上,假设这些缺陷将代表
TPJ-PST与其他大脑区域之间的相互作用受损,包括视觉感知区域(例如V1,
MT),注意网络(VAN,DAN)和思维网络理论(例如MFG,VMPFC)。一个新颖的特征
项目是使用自然主义成像(合作者:Hasson和Leopold博士)的使用,其中激活和
大脑区域之间的功能连接不断监测,而受试者视为生态有效
刺激(例如社交小插曲)。人类Connectome项目的获取和处理方法是
实施并将用于所有研究。总体而言,该计划将使我为独立职业做好准备
使用先进的功能磁共振成像方法,包括基于任务的,静止状态和自然主义fMRI,以研究
神经精神疾病跨社会沟通障碍的神经基础。
相关性:精神分裂症的社会交流受损与长期残疾有关。这
目前的研究调查了这些缺陷的神经基础,并为候选人做准备
研究精神疾病的社会交流缺陷。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Gaurav H Patel其他文献
Gaurav H Patel的其他文献
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{{ truncateString('Gaurav H Patel', 18)}}的其他基金
Neural substrates of deficits in naturalistic social cognition in schizophrenia
精神分裂症自然社会认知缺陷的神经基础
- 批准号:
10626092 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Neural substrates of deficits in naturalistic social cognition in schizophrenia
精神分裂症自然社会认知缺陷的神经基础
- 批准号:
10196984 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Neural substrates of deficits in naturalistic social cognition in schizophrenia
精神分裂症自然社会认知缺陷的神经基础
- 批准号:
10033863 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Behavioral and Neural Correlates of Deficits in Naturalistic Visual and Auditory Social Cognition in Individuals at Clinical High-Risk for Schizophrenia
精神分裂症临床高危个体自然视觉和听觉社会认知缺陷的行为和神经相关性
- 批准号:
10251346 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Behavioral and Neural Correlates of Deficits in Naturalistic Visual and Auditory Social Cognition in Individuals at Clinical High-Risk for Schizophrenia
精神分裂症临床高危个体自然视觉和听觉社会认知缺陷的行为和神经相关性
- 批准号:
10459498 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Neural substrates of deficits in naturalistic social cognition in schizophrenia
精神分裂症自然社会认知缺陷的神经基础
- 批准号:
10412026 - 财政年份:2020
- 资助金额:
$ 19.91万 - 项目类别:
Neural substrates of attention and social cognition impairment in schizophrenia
精神分裂症注意力和社会认知障碍的神经基础
- 批准号:
9531441 - 财政年份:2016
- 资助金额:
$ 19.91万 - 项目类别:
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