UTMB OAIC Metabolism and Biology Resource Core 1 (MBRC1)

UTMB OAIC 代谢和生物学资源核心 1 (MBRC1)

• 批准号: 10443767
• 负责人: Blake B Rasmussen
• 金额: $ 17.07万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10443767
• 关键词: Abbreviations; Aging; American; Animal Model; Animals; Applications Grants; Basic Science; Biological; Biology; Capsicum; Cell Culture Techniques; Cellular biology; Clinical Research; Clinical Trials; Data; Development; Disease; Elderly; Energy Metabolism; Fatty acid glycerol esters; Functional disorder; Funding; Gases; Generations; Glucose; Goals; Grant; Human; Individual; Institutes; Intervention; Isotopes; Knockout Mice; Lead; Mass Fragmentography; Mass Spectrum Analysis; Metabolic; Metabolism; Methodology; Methods; MicroRNAs; Molecular; Molecular Biology; Molecular Biology Techniques; Morphology; Muscle; Muscular Atrophy; Nicotinamide N-Methyltransferase; Pathway interactions; Phenotype; Physical Function; Pilot Projects; Population; Pre-Clinical Model; Proteins; Recovery; Recovery of Function; Research; Research Personnel; Resources; Sampling; Services; Shipping; Testing; Tissues; Tracer; Training; Translating; Translational Research; Translations; United States National Institutes of Health; WFDC2 gene; Work; age effect; biobank; doubly-labeled water; experimental study; functional gain; functional loss; innovation; metabolic phenotype; metabolomics; mouse model; muscle aging; novel; novel therapeutics; protein metabolism; response; sarcopenia; skills; success; tool; transcriptomics

PROJECT SUMMARY/ABSTRACT (MBRC1) The UTMB OAIC Metabolism and Biology Resource Core (MBRC1) promotes and supports basic science and translational research relevant to the OAIC theme which is Translate pathways of functional loss and gain into interventions to optimize functional recovery in diverse geriatric populations. The MBRC1 has been critical to the success of the UTMB OAIC, having supported many key discoveries on the mechanisms of muscle aging and sarcopenia. In the current cycle, it has supported 21 NIH grants, 11 other external grants, and 12 OAIC projects. The MBRC1 specific aims are: 1. Provide analytical support and add value to OAIC research. 2. Develop new methods to study the mechanisms of functional loss and recovery. 3. Train early-stage investigators on the analytical and methodological aspects of basic science and translational research on functional loss, gain and recovery in older adults. MBRC1 supports basic and translational research on sarcopenia, physical dysfunction and recovery requiring metabolic phenotyping, molecular biology techniques, tracer methodologies, animal models and cell cultures. It provides essential tools to determine the dynamic changes that occur at the whole-body, tissue and cellular levels in older individuals; quantify the metabolic effects of age, disease, inactivity and anabolic interventions; and determine the basic mechanisms that underlie these changes. MBRC1 also promotes integration of molecular, cellular and tracer methodologies within individual experiments in animals and humans to discover the mechanisms that underlie specific pathophysiological responses in older adults. It has also evolved to support the next step in translation – large clinical trials – by developing a biobank and services for sample processing and shipping. Over the next cycle, MBRC1 will expand the molecular metabolism resources and support reverse translation by further developing and utilizing inducible muscle specific knockout mouse models, integrating the use of traceromic methods, developing novel therapeutics for sarcopenia, and providing access to institutional metabolomic and transcriptomic resources to OAIC investigators. It will also continue to provide resources for early-stage investigators and OAIC pilot studies, assisting in the generation and utilization of preliminary data for competitive grant applications.

项目摘要/摘要（MBRC1） UTMB OAIC代谢和生物学资源核心（MBRC1）促进和支持基础科学和 与OAIC主题相关的翻译研究，该主题是将功能损失的途径转化为 干预措施以优化潜水员老年人群的功能恢复。 MBRC1对 UTMB OAIC的成功，支持了许多有关肌肉衰老机制的关键发现 和肌肉减少症。在当前周期中，它支持了21个NIH赠款，其他11个外部赠款和12个OAIC 项目。 MBRC1具体目的是： 1。提供分析支持并为OAIC研究增加价值。 2。开发新方法来研究功能损失和恢复的机制。 3.培训早期研究人员基础科学的分析和方法论方面 老年人的功能损失，增益和恢复的转化研究。 MBRC1支持基本和翻译的研究，对肌肉减少症，身体功能障碍和恢复需要 代谢表型，分子生物学技术，示踪剂方法，动物模型和细胞培养物。它 提供了确定全身，组织和细胞处发生的动态变化的基本工具 老年人的水平；量化年龄，疾病，不活跃和合成代谢干预措施的代谢作用； 并确定基于这些变化的基本机制。 MBRC1还促进了 动物和人类的各个实验中的分子，细胞和示踪剂方法发现 老年人特定病理生理反应的基础的机制。它也发展到 通过为样本开发生物库和服务来支持翻译的下一步 - 大型临床试验 处理和运输。 在下一个周期中，MBRC1将扩大分子代谢资源并支持反向翻译 通过进一步开发和使用诱导肌肉特定的敲除鼠标模型，集成了使用的使用 曲目方法，为肌肉减少症开发新的疗法，并提供机构的访问权限 OAIC研究人员的代谢组和转录组学资源。它还将继续为 早期研究人员和OAIC试点研究，协助初步数据的生成和利用 用于竞争性赠款申请。