Pilot/Exploratory Studies Core

试点/探索性研究核心

基本信息

批准号：
8572188
负责人：
Blake B Rasmussen
金额：
$ 5.06万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-06-15 至 2015-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8572188
关键词：
Acute Address Age Aging American Amino Acids Applications Grants Area Biological Biology Clinical Trials Collaborations Data Development Disease Elderly Enrollment Ensure Exercise Fostering Functional disorder Funding Future Goals Growth Hormonal Hospitals Institution Intervention Investigation Lead Mentorship Monitor Muscle Muscle function Observational Study Outcome Pharmacological Treatment Pilot Projects Prevention Proteins Recovery Recovery of Function Recruitment Activity Rehabilitation therapy Research Research Design Research Personnel Research Project Grants Research Proposals Resources Risk Safety Supplementation Training Translating Translational Research Translations clinical practice disability human subject protection improved improved functioning innovation innovative technologies muscle form patient population prevent research facility

项目摘要

The specific aims of the UTMB Claude Pepper Older Americans Independence Center (OAIC) are to: 1) provide core support to funded translational research by UTMB investigators on muscle function and functional recovery in older adults; 2) Stimulate the growth of additional interdisciplinary translational research projects to improve muscle function and functional recovery in older adults by: a) funding pilot project research to generate preliminary data in promising new areas of investigation and b) funding developmental projects to develop innovative technologies; 3) Train future leaders in research in the mechanisms, prevention and treatment of muscle dysfunction and disability in older adults; 4) Recruit established investigators with expertise relevant to muscle function and functional recovery in older adults into interdisciplinary translational research related to the OAIC focus and 5) Foster collaborations between UTMB investigators and investigators at other OAIC and other institutions on studies of muscle function and functional recovery in older adults. The theme for the next cycle of our OAIC is: Translating Biological Mechanisms of Muscle Growth and Loss to Improve Function and Recovery in Older Adults. Our focus is on translating basic discoveries on the mechanisms of muscle loss and re-growth with aging to clinical practice to promote functional recovery and prevent disability in older adults. Observational studies will provide crucial information for selecting appropriate in-hospital, post-discharge, and long-term outcomes for inclusion in clinical trials of geriatric patient populations. Our general hypothesis is that aging induces mild but significant changes in muscle biology and function that progressively lead to muscle loss and predispose to potentially catastrophic declines in muscle mass and function during bouts of acute illness. We also hypothesize that anabolic interventions involving exercise/rehabilitation, amino acid/protein supplementation and hormonal or other pharmacological treatment can prevent the age- and disease-induced muscle loss and reduce the risk of

UTMB 克劳德·佩珀美国老年人独立中心 (OAIC) 的具体目标是：1) 为 UTMB 研究人员资助的肌肉功能转化研究提供核心支持老年人的功能恢复； 2）刺激更多跨学科转化的发展通过以下方式改善老年人肌肉功能和功能恢复的研究项目：a) 资助试点项目研究，以生成有前景的新研究领域的初步数据和 b) 资金开发创新技术的开发项目； 3）培养未来研究领域的领导者老年人肌肉功能障碍和残疾的机制、预防和治疗； 4) 招募建立了具有老年人肌肉功能和功能恢复相关专业知识的研究人员与 OAIC 重点相关的跨学科转化研究，以及 5) 促进之间的合作 UTMB 研究人员以及其他 OAIC 和其他机构的研究人员进行肌肉功能和老年人的功能恢复。我们 OAIC 下一周期的主题是：转化肌肉生长和损失的生物机制改善老年人的功能和恢复。我们的重点是将基本发现转化为随着年龄增长肌肉损失和重新生长的机制应用于临床实践，以促进功能恢复和预防老年人的残疾。观察性研究将为选择提供重要信息适当的院内、出院后和长期结局，纳入老年病临床试验患者人群。我们的一般假设是，衰老会引起肌肉轻微但显着的变化逐渐导致肌肉损失并容易导致潜在灾难性的生物学和功能急性疾病发作期间肌肉质量和功能下降。我们还假设合成代谢涉及运动/康复、氨基酸/蛋白质补充和激素或其他干预措施药物治疗可以预防年龄和疾病引起的肌肉损失，并降低以下风险：