NUTRITIONAL AND CONTRACTILE REGULATION OF MUSCLE GROWTH

肌肉生长的营养和收缩调节

• 批准号: 7378738
• 负责人: Blake B Rasmussen
• 金额: $ 7.77万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378738
• 关键词: NUTRITIONAL; CONTRACTILE; REGULATION; MUSCLE; GROWTH

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Background: The focus of this project is to explore how muscles grow. Muscle wasting is a common phenomenon in many conditions, such as cancer, AIDS, trauma, sepsis, kidney failure, and is also particularly prevalent in the elderly. Specific Aims and Procedures (summary): (1) To determine the magnitude of the short-term response of muscle growth to feeding when the food is given before or after a bout of resistance exercise. (2) To determine the magnitude of the short-term response of muscle growth to food that provides an amount of energy that either matches or exceeds the amount of energy used during the exercise. (3) To determine the differences between women and men in the short-term response of muscle growth to weight lifting alone and in combination with feeding when ingested before or after a bout of weight lifting exercise. The procedures we will use in order to address these specific aims include the use of femoral catheters, weight lifting exercise, blood and breath collection and taking muscle biopsies. During each experiment we will be continuously infusing stable isotopes. Stable isotopes are not radioactive and can be given safely to humans. These stable isotopes allow us to be able to measure short-term muscle growth in humans. Significance (summary): These studies will provide insight into the mechanisms that regulate human muscle growth, and will be utilized as a basis from which to develop interventions for improving muscle growth in conditions such as aging, trauma, cancer, and AIDS.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。背景：该项目的重点是探索肌肉的成长。在许多情况下，肌肉浪费是一种常见现象，例如癌症，艾滋病，创伤，败血症，肾衰竭，在老年人中也尤其普遍。具体目的和程序（摘要）：（1）确定肌肉生长对进食的短期反应的幅度，何时在抵抗运动之前或之后给予食物。 （2）确定肌肉生长对食物的短期反应的幅度，这些响应提供了与运动过程中使用的能量相匹配或超过所用能量量的能量。 （3）确定男女在肌肉生长对单独举重的短期反应中的差异，并在举重锻炼前或之后摄入时摄入时摄入。为了解决这些特定目标，我们将使用的程序包括使用股导管，举重运动，血液和呼吸收集以及进行肌肉活检。在每个实验中，我们将不断地注入稳定的同位素。稳定的同位素不是放射性的，可以安全地给予人类。这些稳定的同位素使我们能够衡量人类的短期肌肉生长。 意义（摘要）：这些研究将提供对调节人类肌肉生长的机制的见解，并将被用作开发干预措施以改善衰老，创伤，癌症和艾滋病等疾病的基础。