2022 Craniofacial Morphogenesis and Tissue Regeneration Gordon Research Conference and Gordon Research Seminar

2022颅面形态发生与组织再生戈登研究会议暨戈登研究研讨会

• 批准号: 10388749
• 负责人: PAMELA C YELICK
• 金额: $ 2.35万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-01-01 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10388749
• 关键词: Adult; Affect; Animal Model; Automobile Driving; Basic Science; Biocompatible Materials; Biology; Biomechanics; Biomedical Engineering; Biophysics; Cellular biology; Clinic; Clinical; Clinical Sciences; Collaborations; Communities; Complex; Computational Biology; Congenital Abnormality; Craniofacial Abnormalities; Data Science; Dental; Dentistry; Development; Developmental Biology; Diagnostic; Discipline; Disease; Dysmorphology; Environment; Environmental Risk Factor; Esthetics; Event; Face; FaceBase; Feedback; Fostering; Future; Genetic; Genetic Determinism; Genetic Diseases; Goals; Head; Health; Homeostasis; Human Genetics; Immunology; Interdisciplinary Study; International; Invertebrates; Journals; Knowledge; Learning; Mechanics; Medical Genetics; Methods; Modeling; Molecular; Molecular and Cellular Biology; Morphogenesis; National Institute of Dental and Craniofacial Research; Natural regeneration; Operative Surgical Procedures; Oral; Organ; Outcome; Participant; Pattern; Peer Review; Prevention; Prevention strategy; Process; Regenerative Medicine; Research; Research Personnel; Resolution; Resources; Role; Scientific Advances and Accomplishments; Scientist; Sense Organs; Shapes; Signal Pathway; Signal Transduction; Students; Tissue Engineering; Tissues; Training; Translations; United States National Institutes of Health; Work; bioelectricity; biomechanical engineering; career; craniofacial; craniofacial complex; craniofacial development; craniofacial disorder; craniofacial repair; craniofacial structure; craniofacial tissue; design; educational atmosphere; functional genomics; graduate student; improved; in vivo imaging; innovation; insight; interdisciplinary approach; medical specialties; meetings; novel; novel strategies; novel therapeutic intervention; posters; programs; regenerative; regenerative approach; repaired; response to injury; stem cell biology; stem cell differentiation; stem cells; symposium; tissue regeneration; tissue repair

Project Summary Goals of craniofacial research are to better understand normal development, the causes underlying craniofacial malformations, and how best to develop diagnostics and therapies to repair craniofacial tissues. In-depth interdisciplinary understanding of developmental biology, craniofacial disease processes and tissue repair can provide essential insight into mechanisms regulating craniofacial morphogenesis and regeneration, and the translation of scientific outcomes to effectively treat the wide variety of clinical disorders affecting the head and face. Such in-depth understanding requires detailed knowledge of the cellular events and molecular signals that control craniofacial tissue patterning, development and repair, and the morphogenetic processes that shape craniofacial tissues and organs. Contemporary developmental studies of the vertebrate craniofacial complex employ multidisciplinary approaches including developmental biology, functional genomics, biomedical engineering, biophysics, and molecular and cellular biology. The study of craniofacial development utilises a wide range of vertebrate and invertebrate models, which collectively provide a variety of experimental approaches to investigate the molecular and cellular mechanisms underlying the morphogenesis of craniofacial structures in both health and disease. These models also offer insight into the evolutionary forces and environmental factors driving the diversity of craniofacial form and function. As such, research in craniofacial development is a key discipline of developmental and cellular biology and aligns well with the scope of prominent peer-reviewed journals. The 2022 Craniofacial Morphogenesis and Tissue Regeneration GRC/GRS proposed here will highlight how interdisciplinary research is rapidly expanding our understanding of craniofacial development and tissue regeneration through talks investigating the integration of molecular and biomechanical signals regulating craniofacial development. Such interdisciplinary approaches are being used to elucidate how developing craniofacial tissues and their environment interact to create craniofacial form and function. The proposed presentations will be accompanied by extensive discussions on how these processes drive the diversity of craniofacial structures, and how many distinctive features of the vertebrate head have evolved. Invited presentations by new and established researchers will discuss new findings in craniofacial morphogenesis and tissue regeneration, with specific focus on the role of mechanical and bioelectric signaling in craniofacial development and tissue regeneration. The meeting will also feature sessions on cell signalling, clinical genetics, sense organs, new animal models of craniofacial disorders, and on novel tissue engineering strategies for regenerative craniofacial tissue repair. The program is designed to promote interactions of basic science researchers, clinician scientists, biomedical engineers and evolutionary biologists of diverse expertise, in order to foster stimulating discussions and productive new collaborations in a highly collegial atmosphere.

项目概要 颅面研究的目标是更好地了解正常发育、颅面的潜在原因 畸形，以及如何最好地开发修复颅面组织的诊断和疗法。深入 对发育生物学、颅面疾病过程和组织修复的跨学科理解可以 提供对调节颅面形态发生和再生的机制的重要见解，以及 转化科学成果以有效治疗影响头部和大脑的各种临床疾病 脸。这种深入的理解需要对细胞事件和分子信号的详细了解 控制颅面组织的模式、发育和修复，以及塑造颅面组织的形态发生过程 颅面组织和器官。 脊椎动物颅面复合体的当代发育研究采用多学科 方法包括发育生物学、功能基因组学、生物医学工程、生物物理学和 分子和细胞生物学。颅面发育的研究利用了广泛的脊椎动物和 无脊椎动物模型，共同提供了多种实验方法来研究分子 以及健康和疾病状态下颅面结构形态发生的细胞机制。 这些模型还提供了对驱动物种多样性的进化力量和环境因素的见解。 颅面的形态和功能。因此，颅面发育研究是发育学的一个关键学科。 和细胞生物学，并且与著名同行评审期刊的范围非常一致。 这里提出的 2022 年颅面形态发生和组织再生 GRC/GRS 将强调如何 跨学科研究正在迅速扩大我们对颅面发育和组织的理解 通过研究分子和生物力学信号调节整合的讲座进行再生 颅面发育。这种跨学科的方法被用来阐明如何发展 颅面组织及其环境相互作用形成颅面的形态和功能。拟议的 演讲将伴随着关于这些过程如何推动多样性的广泛讨论。 颅面结构，以及脊椎动物头部进化了多少独特特征。 新老研究人员的特邀演讲将讨论颅面的新发现 形态发生和组织再生，特别关注机械和生物电信号的作用 颅面发育和组织再生。会议还将举办有关细胞信号传导的会议， 临床遗传学、感觉器官、颅面疾病的新动物模型以及新型组织工程 颅面组织再生修复策略。该计划旨在促进基本的互动 具有不同专业知识的科学研究人员、临床科学家、生物医学工程师和进化生物学家， 以在高度学院化的氛围中促进激动人心的讨论和富有成效的新合作。