Bioengineered Composite Alveolar Bone-Tooth Constructs for Tooth Regeneration

用于牙齿再生的生物工程复合牙槽骨牙齿结构

• 批准号: 10192702
• 负责人: PAMELA C YELICK
• 金额: $ 68.15万
• 依托单位: TUFTS UNIVERSITY BOSTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10192702
• 关键词: 3-Dimensional; Accidental Injury; Accidents; Address; Adult; Affect; Age; Alveolar; Alveolar Bone Loss; Animal Model; Athletic Injuries; Autologous; Biomedical Engineering; Biomimetics; Blood; Bone Regeneration; Bone Resorption; Bone Tissue; Cells; Child; Clinical Trials; Complex; Congenital Abnormality; Craniofacial Abnormalities; Data; Defect; Dental; Dental Implants; Dentistry; Dentition; Development; Disease; Excision; Exhibits; Extracellular Matrix; Family suidae; Gelatin; Genetic; Goals; Growth Factor; Harvest; Health; Health Priorities; Human; Hydrogels; Immune system; Implant; Individual; Injury; Interdisciplinary Study; Jaw; Knowledge; Live Birth; Malignant Neoplasms; Mandible; Maxilla; Methacrylates; Methods; Military Personnel; Minerals; Mission; Modeling; Morbidity - disease rate; National Institute of Dental and Craniofacial Research; Natural regeneration; Nerve; Operative Surgical Procedures; Oryctolagus cuniculus; Persons; Property; Public Health; Publishing; Quality of life; Regenerative Medicine; Replacement Therapy; Reporting; Research; Signal Pathway; Silk; Site; Source; Techniques; Technology; Time; Tissue Engineering; Tissues; Tooth Germ; Tooth Loss; Tooth Tissue; Tooth regeneration; Tooth structure; United States; United States National Institutes of Health; aging population; alveolar bone; base; battlefield injury; bioprinting; bone; cleft lip and palate; clinically relevant; craniofacial; craniofacial complex; craniofacial development; craniofacial repair; design; healing; hydrogel scaffold; improved; innovation; malignant mouth neoplasm; novel; novel strategies; oral surgery specialty; regenerative; regenerative therapy; repaired; scaffold; skeletal; tissue support frame

Project Summary/Abstract The coordinated development of craniofacial jaw bones and teeth are the result of a complex interplay between a surprisingly large and growing number of tissues - including blood and vasculature, and nerves – combined with the immune system, and a multitude of growth factor signaling pathways. Although knowledge of signaling pathways resulting in human mineralized tissue development has improved over the past few decades, detailed knowledge and understanding of how to regenerate human mineralized tissues in a functional and timely manner remains elusive – particularly with respect to the craniofacial complex and teeth. Here we propose novel strategies to effectively and coordinately regenerate alveolar jaw bone and tooth tissues, using three dimensional tissue engineering strategies. The objectives of the proposed studies, which build on our prior published reports, are to characterize two potential models for biomimetic three dimensional alveolar bone-tooth constructs: 1) natural decellularized tooth bud extracellular matrix scaffolds; and 2) Gelatin Methacrylate (GelMA) hydrogel scaffolds. Our published expertise in in the field of regenerative dentistry, mineralized tissue development and disease, strong preliminary data, and team of developmental biologists, clinicians and bioengineers supports our ability to accomplish the proposed Aims. We anticipate that the completion of the proposed studies will result in significantly improved knowledge and understanding of new methods to repair craniofacial defects caused by a variety of insults. The significance of the proposed studies and relevance to public health includes the facts that skeletal and craniofacial defects occur in as many as 1 in 700 live births in the United States alone, and that over a quarter of a million Maxillofacial surgeries were performed in 2014, including oral cancer resections. In addition, injuries to the craniofacial complex that include teeth are increasingly common due to accidents and sports injuries, and particularly in the battlefield where they represent up to 20% of injuries. As such, the proposed studies will make a significant contribution towards improved quality of life of both civilian and military populations.

项目概要/摘要 颅面颌骨和牙齿的协调发育是两者之间复杂相互作用的结果 数量惊人且数量不断增加的组织（包括血液、脉管系统和神经）结合在一起 与免疫系统和多种生长因子信号通路有关。 由此产生的人类矿化组织发育途径在过去几十年中得到了改善，详细 了解和理解如何及时、功能性地再生人体矿化组织 方式仍然难以捉摸——特别是在颅面复合体和牙齿方面。 在这里，我们提出了有效、协调地再生牙槽颌骨和牙齿组织的新策略， 使用三维组织工程策略 所提出的研究的目标是建立在这些策略的基础上的。 我们之前发表的报告旨在描述仿生三维肺泡的两种潜在模型 骨牙结构：1) 天然脱细胞牙芽细胞外基质支架；2) 明胶 甲基丙烯酸酯（GelMA）水凝胶支架。 我们在再生牙科、矿化组织发育和疾病领域发表的专业知识， 强大的初步数据以及发育生物学家、主教和生物工程师团队支持我们的能力 我们预计完成拟议的研究将导致： 显着提高了对修复颅面部缺损新方法的认识和理解 各种侮辱。 拟议研究的重要性以及与公共卫生的相关性包括以下事实：骨骼和 仅在美国，就有多达七百个活产儿中就有一个出现颅面缺陷，并且超过四分之一 2014 年进行了 100 万例颌面手术，其中包括口腔癌切除术以及损伤手术。 由于事故和运动损伤，包括牙齿在内的颅面复合体越来越常见，并且 特别是在战场上，它们所造成的伤害高达 20%，因此，拟议的研究将得出结论。 对提高平民和军人的生活质量做出了重大贡献。

项目成果

Scenario V: Back to the Future: An optimal scenario for pandemic 2026 based on lessons from COVID-19.

情景 V：回到未来：基于 COVID-19 的经验教训，针对 2026 年大流行的最佳情景。

• DOI: 10.1002/jdd.12837
• 发表时间: 2022
• 期刊: Journal of dental education
• 影响因子: 2.3
• 作者: Brownstein,SheriA;Fenesy,KimE;McLaren,Sean;vanderHoeven,Dharini;Walter,Ricardo;Yelick,PamelaC
• 通讯作者: Yelick,PamelaC

TyroFill-Titanium Implant Constructs for the Coordinated Repair of Rabbit Mandible and Tooth Defects.

• DOI: 10.3390/bioengineering10111277
• 发表时间: 2023-11-02
• 期刊: Bioengineering (Basel, Switzerland)