Biostatistics Shared Resource

生物统计共享资源

• 批准号: 10205358
• 负责人: MOTOMI MORI
• 金额: $ 8.92万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-08-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10205358
• 关键词: Advisory Committees; Biological Markers; Biometry; Biostatistics Shared Resource; Budgets; Businesses; Cancer Center; Cancer Control; Cancer Research Project; Cells; Clinical; Clinical Research; Clinical Trials Design; Clinical effectiveness; Collaborations; Combined Modality Therapy; Communities; Complex; Computational Biology; Consult; Consultations; Creativeness; Data; Data Analyses; Data Collection; Data Coordinating Center; Development; Development Plans; Disease; Doctor of Philosophy; Early Diagnosis; Educational workshop; Effectiveness; Ensure; Evaluation; Experimental Designs; Fostering; Genomics; Genomics Shared Resource; Goals; Growth; Growth and Development function; Human Subject Research; Image; Immune; Immunologic Monitoring; Immunotherapeutic agent; Individual; Infrastructure; Institutes; Journals; Learning; Life Cycle Stages; Malignant Neoplasms; Mission; Molecular Target; Monitor; Multi-Institutional Clinical Trial; Play; Population Sciences; Positioning Attribute; Preventive; Procedures; Process; Protocols documentation; Publications; Recommendation; Reporting; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Resource Sharing; Resources; Role; Safety; Sample Size; Science; Southwest Oncology Group; Statistical Data Interpretation; Statistical Methods; Structure; System; Technology; Testing; Therapeutic; Training and Education; Vision; Washington; Work; anticancer research; base; cancer clinical trial; cancer prevention; computational platform; data management; design; experience; genetic technology; imaging modality; improved; innovation; meetings; member; model development; multidimensional data; new technology; novel; operation; phase 1 designs; phase III trial; precision medicine; programs; recruit; response; satisfaction; targeted agent; tool; translational scientist; trial design; web portal

BIOSTATISTICS SHARED RESOURCE Director: Motomi Mori, PhD ABSTRACT / PROJECT SUMMARY The Knight Cancer Institute (Knight) Biostatistics Shared Resource (BSR) is a cancer center managed shared resource with the overarching mission of impacting cancer through biostatistics collaboration and consulting. The BSR's vision is to provide comprehensive and integrated biostatistics support to basic, clinical, population science and translational cancer researchers at the Knight. Fostering collaboration and team-science, the BSR strives to be an integral part of cancer research teams and to provide statistical support throughout the life cycle of the research project from concept development through publication. In addition to providing support to individual researchers, the BSR provides statistical consultation to other Knight supported shared resources, and provides the biostatistics expertise and infrastructure to multi-investigator, transdisciplinary research projects. The BSR has a major role in supporting cancer clinical research, inclusive of trial design, monitoring and analysis. Finally, the BSR actively participates in education and training across the cancer research programs, through seminars and workshops, journal clubs, departmental grand rounds, and research-specific program meetings. As part of our commitment to maximize the effectiveness of the resources structure, the Knight has invested significant resources in the BSR to build expertise and capacity. This commitment is evidenced by the significant increase in operating budget from $267,015 in FY2011 (July 2010 - June 2011) to $1,394,432 in FY16 (July 2015 - June 2016). In response to large trajectory of expected growth over the next five years, a consultant was hired in September 2014 to conduct a comprehensive external evaluation that assessed user satisfaction, operational processes and procedures, and staffing. Following completion of the evaluation, the BSR developed a five-year growth and development plan to ensure high quality biostatistics support to existing investigators, as well as the large number of new investigators being recruited by the Knight. Additionally, as the Knight continues to invest in new technologies including high throughput `omics' technologies, imaging, immune monitoring and cell-based technologies, the BSR needs to be pre-emptive in understanding the data generated by the new technologies, support preprocessing and data management workflows, develop statistical analysis workflows, as well data presentation and interpretation tools. The Knight has committed to continue providing substantial resources to implement recommendations from the task force including the increased staffing to assist with business operations of the unit; development of a more robust staffing model; development of a web-based portal to easily interact and communicate with users, provide project management tools, and track staffing and usage metrics; and recruitment of additional PhD and masters level biostatisticians. Additional goals resulting from the plan include expanding phase I design expertise; integration of biostatistics staff into the disease specific research teams to improve early collaboration with investigators; and coordination with computational biology and the Integrated Genomic Shared Resource to create a seamless pipeline for omics data analysis support. In early 2015 the Knight expanded its collaboration with Cancer Research And Biostatistics (CRAB), a non-profit entity located in Seattle, Washington. As the long-standing statistical and data coordinating center for SWOG, CRAB is a national leader in designing, managing and analyzing therapeutic and preventive cancer clinical trials. The collaboration with CRAB has greatly enhanced our capacity and scope of expertise. The relationship has provided Knight clinical and translational researchers with immediate access to experienced, senior cancer biostatisticians with expertise including multi-site clinical trials, phase III trial designs, and early detection trials. The BSR is directed by Cancer Prevention and Control member Motomi (Tomi) Mori, PhD. The BSR is highly utilized by cancer researchers and consistently demonstrates key scientific contributions. Between 2011 and 2015, the BSR provided biostatistics support to 124 cancer researchers from all four research programs.

生物统计学共享资源 导演：Motomi Mori，博士 摘要 /项目摘要 骑士癌症研究所（Knight）生物统计学共享资源（BSR）是癌症中心的共享 通过生物统计学合作和咨询来影响癌症的总体使命的资源。 BSR的愿景是为基本，临床，人群提供全面和综合的生物统计学支持 骑士的科学与转化癌研究人员。 BSR促进协作和团队科学 努力成为癌症研究团队不可或缺的一部分，并在整个生命周期中提供统计支持 从概念开发到出版的研究项目。除了为 个人研究人员，BSR向其他支持的共享资源提供统计咨询， 并将生物统计学专业知识和基础架构提供给多个评论者，跨学科研究 项目。 BSR在支持癌症临床研究（包括试验设计，监测）方面具有重要作用 和分析。最后，BSR积极参与癌症研究的教育和培训 通过研讨会和研讨会，期刊俱乐部，部门大回合和特定于研究的计划 计划会议。 作为我们致力于最大化资源结构有效性的一部分，骑士已经投资了 BSR的大量资源以建立专业知识和能力。这项承诺得到了重要的 营业预算从2011财年的267,015美元（2010年7月 - 2011年6月）增加到2016财年的1,394,432美元（7月 2015年至2016年6月）。为了回应未来五年预期增长的巨大轨迹，顾问是 于2014年9月雇用，以进行全面的外部评估，以评估用户满意度， 操作过程和程序以及人员配备。评估完成后，BSR开发了 为期五年的增长和发展计划，以确保对现有调查人员的高质量生物统计学支持 以及骑士招募的大量新调查人员。此外，随着骑士的继续 投资新技术，包括高吞吐量的“ OMICS”技术，成像，免疫监测和 基于细胞的技术，BSR需要先发，以了解新的数据。 技术，支持预处理和数据管理工作流程，开发统计分析工作流程， 以及数据显示和解释工具。骑士已承诺继续提供大量 资源以实施工作组的建议，包括增加人员配备，以协助 该单位的业务运营；开发更强大的人员配备模型；开发基于网络的 门户以轻松与用户互动和通信，提供项目管理工具，并跟踪人员配备和 用法指标；并招募了其他博士学位和硕士级生物统计学家。产生的其他目标 该计划包括扩大I阶段设计专业知识；将生物统计学人员整合到特定的疾病中 研究团队改善与研究人员的早期合作；和计算生物学协调 以及集成的基因组共享资源，以创建用于OMICS数据分析支持的无缝管道。 2015年初 实体位于华盛顿的西雅图。作为长期存在的统计和数据协调中心， Crab是设计，管理和分析治疗和预防性癌症临床试验的国家领导者。 与螃蟹的合作大大提高了我们的能力和专业知识范围。关系有 为骑士临床和翻译研究人员提供了立即进入经验丰富的高级癌症 具有专业知识的生物统计学家，包括多站点临床试验，第三阶段试验设计和早期检测试验。 BSR由癌症预防和控制成员Motomi（Tomi）Mori，博士指导。 BSR高度高 由癌症研究人员使用，并始终如一地展示了关键的科学贡献。在2011年至之间 2015年，BSR为来自所有四个研究计划的124名癌症研究人员提供了生物统计学支持。