Biostatistics Shared Resources Core

生物统计学共享资源核心

• 批准号: 9883738
• 负责人: MOTOMI MORI
• 金额: $ 86.36万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-03-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9883738
• 关键词: Acute Lymphocytic Leukemia; Adherence; Affect; Anus; Basic Science; Big Data; Biological; Biometry; Biostatistics Shared Resource; Blood; Bone Density; Bone Mineral Contents; Cancer Center Support Grant; Cancer Control; Child; Childhood Acute Lymphocytic Leukemia; Clinical Investigator; Clinical Oncology; Clinical Research; Clinical Trials; Clinical assessments; Collaborations; Complex; Computer Systems; Computer software; Consult; Consultations; Data; Data Analyses; Department chair; Development; Diagnosis; Disease Marker; Dose; Drug Kinetics; Educational Status; Educational workshop; Enrollment; Ensure; Faculty; Follow-Up Studies; Frequencies; Funding; Genes; Genetic; Genetic Markers; Genomics; Goals; Growth; Immunotherapy; Information Services; Infrastructure; Journals; Laboratories; Late Effects; Life Cycle Stages; Malignant Childhood Neoplasm; Malignant Neoplasms; Measures; Methodology; Methods; Mission; Molecular; Motivation; Mutation; Nature; Neuropathy; Newly Diagnosed; Oncology; Outcome; Paper; Patients; Physical Function; Physical activity; Physical therapy; Population; Process; Publications; Quality of life; Radiation exposure; Radiology Specialty; Randomized; Remission Induction; Research; Research Design; Research Personnel; Research Project Grants; Residual Neoplasm; Resource Sharing; Risk; Saint Jude Children' s Research Hospital; Scientific Advances and Accomplishments; Severities; Survivors; System; Therapeutic; Therapeutic Intervention; Time; Translating; United States; Update; Vincristine; Work; anticancer research; base; cancer clinical trial; cohort; design; disorder subtype; electronic data capture system; exercise intensity; experience; improved; indexing; lectures; leukemia treatment; medulloblastoma; member; multi-site trial; neurotoxicity; personalized medicine; precision medicine; programs; recruit; relapse risk; sound; survivorship; translational scientist; treatment as usual

PROJECT SUMMARY/ABSTRACT— Biostatistics Shared Resource The Biostatistics Shared Resource (BSR) is a SJCCC managed shared resource with the overarching mission of impacting pediatric cancer through biostatistics collaboration and consulting, and through comprehensive, effective, and timely biostatistical support to Center members. BSR has a highly experienced and interactive team of biostatisticians who work collaboratively with researchers who are conducting leading edge basic science, clinical research, and population and survivorship research from the 5 SJCCC Programs. This is evidenced by the high level of collaborative publications and key scientific contributions in high-impact journals such as Journal of Clinical Oncology (n=31), Cancer (n=31), Nature Genetics (n=9), and Lancet Oncology (n=4). In addition, BSR biostatisticians are well integrated into the clinical trial teams providing statistical support throughout the life cycle of the research project from concept development through publication. During the last funding period, 85% of all SJCCC publications used the BSR and 77% (n=358/468) of all collaborative publications with a biostatistician as a co-author were associated with SJCCC programs. These included papers from all 5 of the programs: CCSP (n = 103), CBP (n = 1), DBSTP (n = 66), NBTP (n = 83), and HMP (n = 105). A total of 125 St. Jude investigators and their staff used the BSR during the index year (FY2017). Of those, 71 (57%) were SJCCC members. The BSR faculty also offer workshops, office consultations, lectures, seminars, Grand Rounds, and courses on study design, analysis methods, and software implementation to fellows, research staff, and faculty. The BSR is led by Dr. Deo Kumar Srivastava who has more than 23 years' experience in the statistical design and analysis of cancer research and cancer clinical trials. He is supported by 9 faculty biostatisticians and 13 master's-level trained staff, ensuring that BSR support is available to investigators throughout all 5 programs. During our most recent funding period, BSR has witnessed growth driven by the strengthening of the scientific programs, research in genomic characterization of pediatric cancers, and focus on complex precision medicine SJCCC investigator-initiated multisite trials. Goals for the next funding period include continuing to provide state-of-the-art statistical support to all SJCCC investigators including new investigators, and targeted recruitment of biostatisticians to strengthen expertise in personalized medicine, immunotherapy, and in expansion of high-throughput big data. Lastly, BSR will closely partner with the Information Services department in the implementation of the new software provided by the Clinical Trials Management System.

项目摘要/摘要 - 生物统计学共享资源 生物统计学共享资源（BSR）是带有总体任务的SJCCC托管共享资源 通过生物统计学合作和咨询来影响小儿癌，以及通过全面的 对中心成员有效，及时的生物统计支持。 BSR具有经验丰富且互动的 生物统计学家团队与正在领先基本的研究人员合作 来自5个SJCCC计划的科学，临床研究以及人口以及生存研究。这是 高水平的合作出版物和高影响力期刊的关键科学贡献所证明 例如临床肿瘤学期刊（n = 31），癌症（n = 31），自然遗传学（n = 9）和柳叶刀肿瘤学（n = 4）。 此外，BSR生物统计学家已很好地整合到提供统计支持的临床试验团队中 在整个研究项目的整个生命周期中，从概念开发到出版。最后 资金期，所有SJCCC出版物中有85％使用BSR，所有协作中的77％（n = 358/468） 与生物统计学家作为合着者的出版物与SJCCC计划有关。这些包括论文 从所有5个程序中：CCSP（n = 103），CBP（n = 1），DBSTP（n = 66），NBTP（n = 83）和HMP（n = 105）。 在指数年（2017财年），共有125名圣裘德调查员及其工作人员使用了BSR。其中71 （57％）是SJCCC成员。 BSR教职员工还提供讲习班，办公室咨询，讲座，半手 大回合以及研究设计，分析方法和软件实施的课程， 研究人员和教师。 BSR由拥有23年以上的Deo Kumar Srivastava博士领导 癌症研究和癌症临床试验的统计设计和分析经验。他得到了 9位教师生物统计学家和13名师父训练有素的员工，以确保BSR支持可供您使用 整个5个计划的调查人员。在我们最近的资金期间，BSR目睹了增长 在加强科学计划的驱动下，小儿癌基因组表征的研究， 并专注于复杂的精密医学SJCCC研究者发起的多站点试验。下一个资金的目标 期间包括继续向所有SJCCC调查人员提供最先进的统计支持 调查人员并针对招募生物统计学家来增强个性化医学专业知识， 免疫疗法，并扩大高通量大数据。最后，BSR将与 信息服务部在实施临床试验提供的新软件 管理系统。