IMPLICATIONS OF HLA POLYMORPHISM FOR DONOR RECRUITMENT

HLA 多态性对捐赠者招募的影响

• 批准号: 2685483
• 负责人: MOTOMI MORI
• 金额: $ 21.89万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-04-01 至 2001-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2685483
• 关键词: alleles; bone marrow transplantation; clinical research; electron microscopy; genetic polymorphism; geographic site; histocompatibility antigens; histocompatibility typing; homologous transplantation; human subject; phenotype; racial /ethnic difference; statistics /biometry; tissue donors; tissue resource /registry

DESCRIPTION: (Adapted from Investigator's Abstract) During the last three decades, bone marrow transplantation (BMT) has become the standard care for the treatment of many hematological malignancies. The idea donor, one who possesses the same HLA-A, B, DR phenotype as that of the patient, is found less than 35% of the time among family members and less than 50% of the time among unrelated donors. Furthermore, minority patients have even lower probability of finding an HLA matched donor. The overall goals of this project are to evaluate the feasibility of finding unrelated matched donors for bone marrow transplant (BMT) patients as a function of HLA-A, B, DR phenotype, race and geographical location of recipient and donor, to develop projections which will facilitate management strategies for recruiting marrow donors on the basis of race and geographical location, and to develop tools which will permit analysis of clinical outcomes on the basis of the probability of haplotype match rather than phenotype match among unrelated BMT patients. Specific aims of the project are to: (1) compare HLA polymorphism among various racial groups and in different geographical regions of the United States; (2) estimate the probability of finding a 6/6 HLA-A, B, DR match and 6/6 or 5/6 match various racial groups as well as for geographically defined groups; (3) estimate the number of donors required from each racial group and geographical region in order to achieve equal access among various racial groups: (4) assess the extent to which European and other foreign marrow donor registries can assist U.S. patients in finding a matched donor by contributing to the diversity of phenotypes represented in the registry: (5) evaluate HLA polymorphism using DNA typing data and to estimate the probability of finding an HLA match at the level of allele rather than antigen for each racial group; (6) evaluate the impact of changes in matching criteria based on molecular determinations of phenotype upon the probability of finding a matched donor for each racial group; (7) develop tools which permit evaluation of impact of genotype match on clinical outcomes among unrelated BMT patients.

描述：（根据调查员的摘要进行了改编） 三十年来，骨髓移植（BMT）已成为标准 护理许多血液恶性肿瘤的治疗。 这个想法 捐助者，拥有相同HLA-A，B，博士表型的捐助者 患者在家庭成员中发现不到35％的时间 无关捐助者的时间不到50％。 此外，少数 患者找到匹配HLA匹配的供体的可能性较低。 该项目的总体目标是评估 寻找无关匹配的骨髓移植供体（BMT） 患者与HLA-A，B，DR表型，种族和地理位置的关系 接收者和捐助者的位置，开发预测 促进管理策略，以招募骨髓捐赠者 种族和地理位置的基础，并开发将 允许根据临床结果分析 单倍型匹配而不是无关BMT中的表型匹配 患者。 该项目的具体目的是：（1）比较HLA 各种种族群体和不同地理的多态性 美国地区； （2）估计查找的概率 A 6/6 HLA-A，B，DR Match和6/6或5/6匹配各种种族群体 以及地理定义的群体； （3）估计数量 每个种族群体和地理区域都需要捐助者 在各个种族群体之间达到平等的机会：（4）评估 欧洲和其他外国骨髓捐赠者可以在多大程度上可以 通过为美国患者贡献 注册表中代表的表型的多样性：（5）评估HLA 使用DNA分型数据的多态性，并估算 在等位基因的水平上找到HLA匹配，而不是抗原 种族群体； （6）评估匹配标准变化的影响 基于对表型的分子测定的概率 为每个种族群体找到一个匹配的捐助者； （7）开发工具 允许评估基因型匹配对临床结果的影响 无关的BMT患者。