Role of the Decision-Making Reference Point in Cognition and Psychopathology

决策参考点在认知和精神病理学中的作用

基本信息

批准号：
10372606
负责人：
PAUL W GLIMCHER
金额：
$ 21.19万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-22 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10372606
关键词：
Adult Affective Anhedonia Behavioral Behavioral Mechanisms Brain Categories Clinical Cognition Coupled Data Decision Making Depressive disorder Development Diagnosis Disease Dopamine Environment Event Formulation Goals Health Human Individual Language Learning Light Link Major Depressive Disorder Measurement Measures Mental Depression Mental Health Modeling Mood Disorders Moods Neurosciences Outcome Pathologic Pathology Patient Self-Report Patients Persons Phenotype Population Positive Reinforcements Positive Reinforcer Predisposition Property Psychopathology Psychophysics Punishment Research Research Domain Criteria Rewards Rodent Role Science Speed Structure System Testing Time Work base clinical phenotype computer framework depressive symptoms expectation experience experimental study instrument negative affect negative mood neurobiological mechanism psychologic reinforcer response tool

项目摘要

Project Summary Mood disorders are characterized by a tendency to subjectively evaluate objectively positive outcomes in a negative light. A fundamental feature of nearly all standard models of decision- making is the idea that the subjective value of any choice option is shaped by one’s internal expectation, or ‘reference point’. Using behavioral decision-making tasks informed by an understanding of how human expectations are set, here propose to test the hypothesis that affective mood impacts the decision-making reference point—the computational instantiation of our expectations—and thus drives shifts in subjective value that mark mood pathologies like major depressive disorder (MDD). In our first Aim we seek to establish that mood correlates with the static state of the reference point in health choosers and that in mood disorders, principally MDD, the level of pathology correlates with the easily and objectively measured reference point. In the second aim we propose to extend these tools to correlate the rate of dynamic reference point resetting with mood state and depressive symptoms in healthy and pathological populations. We hypothesize that developing a neurocomputational framework for understanding the role of the reference point in psychopathology may offer a new construct for use in the RDoC framework.

项目摘要情绪障碍的特征是客观评估消极的结果。几乎所有标准决策模型的基本特征 - 做出的想法是，任何选择选项的主观价值都由一个人的内部塑造期望或“参考点”。使用行为决策任务了解人类期望的设定，这里提出了检验以下假设情感情绪影响决策参考点 - 我们的期望 - 因此，使情绪病理等主观价值变化重度抑郁症（MDD）。在我们的第一个目标中，我们试图确定情绪与健康选择者参考点的静态状态和情绪障碍，主要是 MDD，病理水平与易于和客观测量的参考点相关。在第二个目标中，我们建议扩展这些工具以关联动态参考的速率在健康和病理中以情绪状态和抑郁症状重置点人群。我们假设开发一个神经计算框架了解参考点在心理病理学中的作用可能为在RDOC框架中使用。