Role of the Decision-Making Reference Point in Cognition and Psychopathology

决策参考点在认知和精神病理学中的作用

基本信息

批准号：
10372606
负责人：
PAUL W GLIMCHER
金额：
$ 21.19万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-12-22 至 2023-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10372606
关键词：
Adult Affective Anhedonia Behavioral Behavioral Mechanisms Brain Categories Clinical Cognition Coupled Data Decision Making Depressive disorder Development Diagnosis Disease Dopamine Environment Event Formulation Goals Health Human Individual Language Learning Light Link Major Depressive Disorder Measurement Measures Mental Depression Mental Health Modeling Mood Disorders Moods Neurosciences Outcome Pathologic Pathology Patient Self-Report Patients Persons Phenotype Population Positive Reinforcements Positive Reinforcer Predisposition Property Psychopathology Psychophysics Punishment Research Research Domain Criteria Rewards Rodent Role Science Speed Structure System Testing Time Work base clinical phenotype computer framework depressive symptoms expectation experience experimental study instrument negative affect negative mood neurobiological mechanism psychologic reinforcer response tool

项目摘要

Project Summary Mood disorders are characterized by a tendency to subjectively evaluate objectively positive outcomes in a negative light. A fundamental feature of nearly all standard models of decision- making is the idea that the subjective value of any choice option is shaped by one’s internal expectation, or ‘reference point’. Using behavioral decision-making tasks informed by an understanding of how human expectations are set, here propose to test the hypothesis that affective mood impacts the decision-making reference point—the computational instantiation of our expectations—and thus drives shifts in subjective value that mark mood pathologies like major depressive disorder (MDD). In our first Aim we seek to establish that mood correlates with the static state of the reference point in health choosers and that in mood disorders, principally MDD, the level of pathology correlates with the easily and objectively measured reference point. In the second aim we propose to extend these tools to correlate the rate of dynamic reference point resetting with mood state and depressive symptoms in healthy and pathological populations. We hypothesize that developing a neurocomputational framework for understanding the role of the reference point in psychopathology may offer a new construct for use in the RDoC framework.

项目概要情绪障碍的特点是倾向于主观评价客观积极的事物几乎所有标准决策模型的一个基本特征是：任何选择的主观价值都是由一个人的内在决定的期望，或“参考点”。了解人类期望是如何设定的，这里建议检验以下假设：情感情绪影响决策参考点——计算实例我们的期望 - 从而推动主观价值的转变，标志着情绪病理，例如在我们的第一个目标中，我们试图确定情绪与重度抑郁症（MDD）的相关性。健康选择者和情绪障碍的参考点的静态状态，主要是 MDD，病理水平与容易且客观测量的参考点相关。在第二个目标中，我们建议扩展这些工具以关联动态参考率健康和病理状态下的情绪状态和抑郁症状的点重置我们一直在开发一个神经计算框架。了解参考点在精神病理学中的作用可能会提供一个新的构建在 RDoC 框架中使用。