Academic Leadership Award - The Translational Rehabilitation in Geroscience Initiative

学术领导奖 - 老年科学转化康复倡议

• 批准号: 10201136
• 负责人: LaDora V Thompson
• 金额: $ 16.2万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10201136
• 关键词: Address; Affect; Age; Aging; Area; Arthritis; Assessment tool; Award; Basic Science; Biological; Biological Models; Biology of Aging; Boston; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Custom; Development; Disease; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Ensure; Environment; Etiology; Faculty; Fostering; Foundations; Funding; Geroscience; Grant; Human; Individual; Infrastructure; Institution; Interdisciplinary Education; Interdisciplinary Study; International; Intervention; Knowledge; Laboratories; Lead; Leadership; Mentors; Methodology; Molecular; Movement; Mus; Muscle; Phase I Clinical Trials; Phenotype; Physical therapy; Pilot Projects; Population; Positioning Attribute; Predisposition; Process; Prognosis; Program Research Project Grants; Publications; Recruitment Activity; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Training; Resources; Science; Scientist; Seminal; Stroke; Students; Testing; Tissues; Training; Transcend; Translational Research; Translations; Universities; Work; authority; base; bench to bedside; career development; clinical investigation; cohesion; design; disability; disability risk; education resources; educational atmosphere; experience; frailty; human old age (65+); improved; injury recovery; innovation; meetings; mouse model; multidisciplinary; muscle physiology; new technology; pre-clinical; professor; programs; recruit; rehabilitation research; rehabilitation science; sarcopenia; skills; translational scientist

ABSTRACT The long-term objective of this NIA Leadership Award is to create a robust, highly visible, innovative, and sustainable “interdisciplinary translational rehabilitation Geroscience-focused research and education program” as a cornerstone of research excellence at BU. This includes both bench to early-stage clinical investigations and the reverse in highly prevalent disease-specific conditions such as arthritis, stroke, and frailty. To accomplish its long-term objective, this Leadership Award will carry out three specific aims. Aim#1: Expand the knowledge in translational rehabilitation and Geroscience by catalyzing research and education through the establishment of a cohesive infrastructure, the Translational Rehabilitation in Geroscience Initiative (TRIG Initiative). Aim#2: Create an exceptional research and educational environment that fosters development of successful multidisciplinary translational rehabilitation Geroscience-based investigators with customized expertise in preclinical and clinical science. Aim#3: Establish a pilot grant program to support the most promising translational rehabilitation Geroscience-focused studies. These specific aims will be achieved through the candidate’s leadership of the TRIG Initiative, the breaking down of silos, and the meaningful collaboration with the multitude of existing resources for interdisciplinary research and education. In support of Aim 1, the TRIG Initiative will be created through active recruitment of an interdisciplinary group of scientists, clinicians, and trainees across Boston’s academic and clinical institutions and regular discussions on translational rehabilitation research and Geroscience themes. In support of Aim 2, interdisciplinary partnerships with key stakeholders across the entire university and Boston community will be developed to offer rich research and educational opportunities for the career development of students and investigators with tailored expertise in translational rehabilitation science and Geroscience (e.g., seminars, workshops, collaborative laboratory meetings, courses.) In support of Aim 3, an annual pilot grant program will fund multidisciplinary, translational research that spans between basic and early-stage clinical sciences. The candidate is an internationally recognized muscle physiologist, a leading authority on mechanisms contributing to sarcopenia, and established the mouse frailty phenotype assessment tool in order to conduct translational research to tease out the etiology of frailty. The candidate has the necessary scientific expertise, leadership skills, clinical and research training, and mentoring and teaching experience to lead the TRIG Initiative, implement new activities and curriculum, and accomplish the stated aims of this proposal. Through the support of this NIA K07 Leadership Award and leveraging an impressive array of valuable research and educational resources through BU and the Boston area, the TRIG Initiative envisions active interdisciplinary faculty and trainees engaging in collaborative research, publications and education, building translational rehabilitation Geroscience-based research that culminates in program project grant submission and awards.

抽象的 NIA 领导奖的长期目标是创建一个强大的、高度可见的、创新的和 可持续的“以老年科学为重点的跨学科转化康复研究和教育计划” 作为 BU 卓越研究的基石，这包括早期临床研究和 在关节炎、中风和虚弱等高度流行的疾病特定情况下，情况恰恰相反。 长期目标，该领导力奖将实现三个具体目标：扩展知识。 通过建立促进研究和教育的转化康复和老年科学 一个有凝聚力的基础设施，老年科学转化康复倡议（TRIG 倡议）： 创造一个卓越的研究和教育环境，促进成功的发展 多学科转化康复 基于老年科学的研究人员，具有定制的专业知识 目标#3：建立试点资助计划来支持最有前途的研究。 这些具体目标将通过以老年科学为重点的转化康复研究来实现。 候选人对 TRIG 计划的领导力、打破孤岛以及与 用于跨学科研究和教育的大量现有资源 为了支持目标 1，TRIG。 该倡议将通过积极招募由科学家、圣人和学者组成的跨学科小组来创建。 波士顿学术和临床机构的学员以及关于转化康复的定期讨论 研究和老年科学主题支持目标 2，与主要利益相关者建立跨学科伙伴关系。 整个大学和波士顿社区将被开发以提供丰富的研究和教育 为具有转化专业知识的学生和研究人员提供职业发展的机会 康复科学和老年科学（例如研讨会、讲习班、协作实验室会议、课程。） 为了支持目标 3，年度试点资助计划将资助跨学科、转化性研究 介于基础科学和早期临床科学之间的候选人是国际公认的强者。 生理学家，肌肉减少症机制方面的权威，并确定了小鼠的衰弱 表型评估工具，以便进行转化研究，找出衰弱的病因。 候选人具有必要的科学专业知识、领导技能、临床和研究培训以及指导 和教学经验来领导 TRIG 计划，实施新的活动和课程，并完成 通过 NIA K07 领导奖的支持并利用 通过 BU 和波士顿地区 TRIG 提供一系列令人印象深刻的宝贵研究和教育资源 倡议设想积极的跨学科教师和学员参与合作研究、出版 和教育，建立转化康复基于老年科学研究的项目 项目拨款提交和奖励。