2007 Aging, Biology of Gordon Conference

2007年戈登会议的衰老、生物学

• 批准号: 7329978
• 负责人: LaDora V Thompson
• 金额: $ 5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7329978
• 关键词: Aging; Aging-Related Process; Area; Biological; Biological Models; Biology of Aging; Caenorhabditis elegans; Cell physiology; Cells; Cellular Stress; Clinical; DNA; DNA Damage; DNA Repair; Dietary Intervention; Disease; Elderly; Faculty; Funding; Funding Applicant; Future; Genetic; Goals; Health; Holly; Human; Intervention; Link; Lipids; Longevity; Maintenance; Modeling; Molecular; Molecular and Cellular Biology; Nature; Nuclear Receptors; Numbers; Organism; Physiology; Postdoctoral Fellow; Proteins; Purpose; Quality of life; Range; Research; Research Personnel; Resistance; Rodent; Science; Scientist; Stem cells; Stress; Students; Switzerland; System; Therapeutic; Tissues; Translating; Translational Research; age related; macromolecule; novel; prevent; programs; repaired; symposium

DESCRIPTION (provided by applicant): Funds are requested to provide partial support for the Gordon Research Conference (GRC) on the Biology of Aging. The theme of the 2007 conference will be "Maintenance of Macromolecular Integrity in Aging" to be held at the Les Diablerets Conference Center, Les Diablerets, Switzerland, from September 23 - 28, 2007. Drs. LaDora V. Thompson, Holly Brown-Borg and Alexander B¿rkle will organize the scientific program. Our aim here is to provide funds to support invited speakers, discussion leaders, and junior scientists (postdoctoral fellows, advanced graduate students, or new, junior faculty) who would benefit from and contribute to the conference. The speakers we have invited are internationally recognized for their research on the molecular and cellular biology of aging, physiology of aging, and genetics of aging. These speakers are known to be strong communicators of their science, who stimulate, and participate in, lively discussion. Accumulating damage of DNA has long been suggested as one of the major forms of damage that contribute to the aging process, and life spans of mammalian species positively correlate with the cellular capacity for DNA repair. But other biological macromolecules such as proteins and lipids are also known to undergo molecular damage, aggregation, and misfolding which could contribute to the aging process. Stem cells and nuclear receptors are currently being intensively investigated in their contribution to the aging process. In recent years, a large number of genetic, pharmacological and dietary interventions have been described that slow down aging in various systems ranging from unicellular organisms to humans. Many such interventions have been mechanistically linked with cellular maintenance functions and/or cellular stress resistance; they can be expected to reduce the vulnerability of cells and tissues and thus prevent age-related pathological changes. Lastly, models of accelerated aging have enhanced our understanding of cellular maintenance and stress resistance. The Gordon Research Conference will focus on these hot topics. The rationale behind the choice of these themes is the remarkable convergence of the results from the models systems to investigate cellular maintenance and integrity. The goals of the conference:-To critically assess progress in the biology of aging; To determine whether the biology of aging informs on the nature/causes of age-related decline and disease; To emphasize integrative and translational research findings as a means to develop novel future avenues for therapeutic options that extend health span. The overall purpose of the Gordon Research Conference on The Biology of Aging, "Maintenance of Macromolecular Integrity in Aging" is to bring together investigators in diverse areas of aging and investigators outside the field to discuss the current research in the field and to consider the potential to translate scientific progress into clinical interventions. The ability of cellular macromolecules (e.g., DNA, proteins, lipids) to maintain integrity, using various cellular processes (e.g. repair, degradation and replacement) and several model systems (C. elegans, rodents, fungal, accelerated aging models), is at the forefront of the biology of aging and the extension of health span. We fully anticipate that progress in this field will pave the way for interventions and quality of life for the older adult.

描述（由适用提供）：要求资金为戈登研究会议（GRC）提供有关衰老生物学的部分支持。 2007年会议的主题将是在2007年9月23日至28日，瑞士Les Diablerets的Les Diablerets会议中心的Les Diablerets会议中心举行的“维持大分子的衰老”。 Ladora V. Thompson，Holly Brown-Borg和Alexander B rkle将组织科学计划。我们的目的是提供资金，以支持受邀演讲者，讨论领袖和初级科学家（博士后研究员，高级研究生或新的，初级教师），他们将受益并为会议做出贡献。我们邀请的说话者因其对衰老，衰老生理学和衰老遗传学的分子和细胞生物学的研究而受到国际认可。众所周知，这些说话者是他们科学的强大沟通者，他们刺激并参与了活泼的讨论。长期以来，DNA的累积损害一直被认为是导致衰老过程的主要损害形式之一，哺乳动物物种的生命跨度与DNA修复的细胞能力呈正相关。但是，已知其他生物学大分子（例如蛋白质和脂质）也会受到分子损伤，聚集和错误折叠，这可能有助于衰老过程。目前，正在对干细胞和核接收器对衰老过程的贡献进行深入研究。近年来，已经描述了大量遗传，药物和饮食干预措施，这些干预措施在各种系统中降低了衰老，从单细胞生物到人类。许多这样的干预措施已机械地与细胞维持功能和/或细胞应激性抗性联系在一起。可以预期它们会减少细胞和组织的脆弱性，从而防止与年龄相关的病理变化。最后，加速衰老的模型增强了我们对细胞维持和压力抗性的理解。戈登研究会议将重点关注这些热门话题。这些主题选择背后的基本原理是模型系统结果的显着收敛，以研究细胞维护和完整性。会议的目标： - 严格评估衰老生物学的进步；确定有关年龄相关下降和疾病的性质/原因的老化信息的生物学；强调综合和翻译的研究结果，以开发用于扩展健康范围的治疗选择的新颖未来途径。戈登衰老生物学研究会议的总体目的是，“维持衰老中的大分子完整性”是将衰老和研究人员的研究人员聚集在一起，以讨论该领域的当前研究，并考虑将科学进步转化为临床干预措施的潜力。细胞大分子（例如DNA，蛋白质，脂质）使用各种细胞过程（例如维修，降解和替换）和多种模型系统（C. exemans，啮齿动物，真菌，真菌，加速衰老模型）维持完整性的能力，是健康和延伸性的生物学的最佳选择。我们完全预测，该领域的进步将为老年人的干预和生活质量铺平道路。