Academic Leadership Award - The Translational Rehabilitation in Geroscience Initiative

学术领导奖 - 老年科学转化康复倡议

• 批准号: 10592362
• 负责人: LaDora V Thompson
• 金额: $ 15.8万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592362
• 关键词: Acceleration; Address; Affect; Age; Aging; Area; Arthritis; Assessment tool; Authorization documentation; Award; Basic Science; Biological; Biological Models; Biology of Aging; Boston; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Development; Disease; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Endowment; Ensure; Environment; Etiology; Faculty; Fostering; Foundations; Funding; Geroscience; Grant; Human; Individual; Infrastructure; Institution; Interdisciplinary Education; Interdisciplinary Study; International; Intervention; Knowledge; Laboratories; Leadership; Mentors; Methodology; Molecular; Movement; Mus; Muscle; Phase I Clinical Trials; Phenotype; Physical therapy; Pilot Projects; Population; Positioning Attribute; Predisposition; Process; Prognosis; Program Research Project Grants; Publications; Recruitment Activity; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Training; Resources; Science; Scientist; Seminal; Stroke; Students; Testing; Tissues; Training; Transcend; Translational Research; Translations; Universities; Work; authority; bench to bedside; career development; clinical investigation; clinical training; design; disability; disability risk; education resources; educational atmosphere; experience; frailty; human old age (65+); improved; injury recovery; innovation; knowledge integration; meetings; mouse model; multidisciplinary; muscle physiology; new technology; pre-clinical; professor; programs; recruit; rehabilitation research; rehabilitation science; sarcopenia; skills; skills training; synergism; translational scientist; Acceleration; Address; Affect; Age; Aging; Area; Arthritis; Assessment tool; Authorization documentation; Award; Basic Science; Biological; Biological Models; Biology of Aging; Boston; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Development; Disease; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Endowment; Ensure; Environment; Etiology; Faculty; Fostering; Foundations; Funding; Geroscience; Grant; Human; Individual; Infrastructure; Institution; Interdisciplinary Education; Interdisciplinary Study; International; Intervention; Knowledge; Laboratories; Leadership; Mentors; Methodology; Molecular; Movement; Mus; Muscle; Phase I Clinical Trials; Phenotype; Physical therapy; Pilot Projects; Population; Positioning Attribute; Predisposition; Process; Prognosis; Program Research Project Grants; Publications; Recruitment Activity; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Training; Resources; Science; Scientist; Seminal; Stroke; Students; Testing; Tissues; Training; Transcend; Translational Research; Translations; Universities; Work; authority; bench to bedside; career development; clinical investigation; clinical training; design; disability; disability risk; education resources; educational atmosphere; experience; frailty; human old age (65+); improved; injury recovery; innovation; knowledge integration; meetings; mouse model; multidisciplinary; muscle physiology; new technology; pre-clinical; professor; programs; recruit; rehabilitation research; rehabilitation science; sarcopenia; skills; skills training; synergism; translational scientist

ABSTRACT The long-term objective of this NIA Leadership Award is to create a robust, highly visible, innovative, and sustainable “interdisciplinary translational rehabilitation Geroscience-focused research and education program” as a cornerstone of research excellence at BU. This includes both bench to early-stage clinical investigations and the reverse in highly prevalent disease-specific conditions such as arthritis, stroke, and frailty. To accomplish its long-term objective, this Leadership Award will carry out three specific aims. Aim#1: Expand the knowledge in translational rehabilitation and Geroscience by catalyzing research and education through the establishment of a cohesive infrastructure, the Translational Rehabilitation in Geroscience Initiative (TRIG Initiative). Aim#2: Create an exceptional research and educational environment that fosters development of successful multidisciplinary translational rehabilitation Geroscience-based investigators with customized expertise in preclinical and clinical science. Aim#3: Establish a pilot grant program to support the most promising translational rehabilitation Geroscience-focused studies. These specific aims will be achieved through the candidate’s leadership of the TRIG Initiative, the breaking down of silos, and the meaningful collaboration with the multitude of existing resources for interdisciplinary research and education. In support of Aim 1, the TRIG Initiative will be created through active recruitment of an interdisciplinary group of scientists, clinicians, and trainees across Boston’s academic and clinical institutions and regular discussions on translational rehabilitation research and Geroscience themes. In support of Aim 2, interdisciplinary partnerships with key stakeholders across the entire university and Boston community will be developed to offer rich research and educational opportunities for the career development of students and investigators with tailored expertise in translational rehabilitation science and Geroscience (e.g., seminars, workshops, collaborative laboratory meetings, courses.) In support of Aim 3, an annual pilot grant program will fund multidisciplinary, translational research that spans between basic and early-stage clinical sciences. The candidate is an internationally recognized muscle physiologist, a leading authority on mechanisms contributing to sarcopenia, and established the mouse frailty phenotype assessment tool in order to conduct translational research to tease out the etiology of frailty. The candidate has the necessary scientific expertise, leadership skills, clinical and research training, and mentoring and teaching experience to lead the TRIG Initiative, implement new activities and curriculum, and accomplish the stated aims of this proposal. Through the support of this NIA K07 Leadership Award and leveraging an impressive array of valuable research and educational resources through BU and the Boston area, the TRIG Initiative envisions active interdisciplinary faculty and trainees engaging in collaborative research, publications and education, building translational rehabilitation Geroscience-based research that culminates in program project grant submission and awards.

抽象的 NIA领导奖的长期目标是创建一个健壮，可见，创新的，并且 可持续的“跨学科翻译康复研究与教育计划” 作为BU研究卓越研究的基石。这既包括基准至早期临床调查，也包括 在高度普遍的疾病特异性疾病中的逆转，例如关节炎，中风和脆弱。实现它 长期目标，该领导奖将实现三个具体目标。目标＃1：扩展知识 通过建立催化研究和教育的转化康复和果仁科学 凝聚力的基础设施，《 Geroscience倡议》（TRIG Initiative）的转化康复。 AIM＃2： 创建一个卓越的研究和教育环境，促进成功的发展 具有自定义专业知识的基于Geroscience的多学科翻译康复研究人员 临床前和临床科学。目标＃3：建立一个试点赠款计划，以支持最有前途的 翻译康复以Geroscience为中心的研究。这些具体目标将通过 候选人对触发倡议的领导，孤岛的分解以及有意义的合作 跨学科研究和教育的现有资源大量资源。为了支持AIM 1，Trig 主动性将通过积极招募一个跨学科的科学家，临床医生和 波士顿学术和临床机构的学员以及有关转化康复的定期讨论 研究和Geroscience主题。为了支持AIM 2，与主要利益相关者建立跨学科的伙伴关系 在整个大学和波士顿社区中，将开发出丰富的研究和教育 具有量身定制专业知识的学生和调查人员的职业发展机会 康复科学和GEROSCIENCE（例如，半手，讲习班，协作实验室会议，课程）。 为了支持AIM 3，年度试点赠款计划将资助跨越的跨学科，翻译的研究 在基本和早期临床科学之间。候选人是国际公认的肌肉 生理学家，促成肌肉减少症的机制的领先权威，并建立了老鼠脆弱的 表型评估工具为了进行转化研究以教授脆弱的病因。这 候选人具有必要的科学专业知识，领导能力，临床和研究培训以及心理 和教学经验以领导触发倡议，实施新的活动和课程并完成 该提议的既定目标。通过这一NIA K07领导奖的支持，并利用 通过BU和波士顿地区，令人印象深刻的宝贵研究和教育资源，Trig Initiative设想积极的跨学科教师和学员从事合作研究，出版物 和教育，建立基于GEROSCIENCE的转化康复研究，该研究最终达到计划 项目授予提交和奖励。