Training Grant: Functional Proteomics of Aging

培训补助金：衰老的功能蛋白质组学

• 批准号: 7597010
• 负责人: LaDora V Thompson
• 金额: $ 21.88万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2013-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7597010
• 关键词: Aging; Grant; Proteomics; Training; Aging; Grant; Proteomics; Training

DESCRIPTION (provided by applicant): We seek support for an interdisciplinary Training Program in Functional Proteomics of Aging for both predoctoral and postdoctoral trainees at the University of Minnesota. This Training Program contains two major components: (1) Research training that focuses on the use of proteomic technology to reveal the molecular details behind the age-related loss in tissue function. (2) Didactic and experiential training in gerontology and proteomics to provide trainees with a solid foundation for launching successful careers in aging research. The research component of this Training Program consists of three research areas that focus on retaining physiological function during aging: muscle (Thomas, Thompson, Lowe, Arriaga, Ervasti), the central nervous system (Olsen, Ferrington, Low, Ervasti) and metabolism and longevity (Bernlohr, Arriaga, Griffin, Hendrickson, Kim, Low). These Program Faculty members are drawn from two graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB) and Rehabilitation Sciences (RSc). Proteomic analysis is utilized by Training Faculty to reveal altered protein content, binding partners, and post-translational modifications that occur in aged tissue. This information aids in determining the mechanistic basis for age-related changes in protein structure and function. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers, such as the Center for Mass Spectrometry and Proteomics, and other analytical equipment in Training Faculty laboratories. The Training Program will also include both didactic training via coursework in gerontology and proteomics, as well as experiential training in aging research via seminars, symposia, journal clubs, and group meetings with Program Faculty members. Completion of the Training Program coursework will qualify trainees for a Gerontology Graduate Minor, thus providing direction for trainees' future career goals. The experiential training is designed to maximize interaction among trainees and Training Faculty from multiple labs. In summary, the primary goal of this Training Program is to help exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research.

描述（由申请人提供）：我们寻求支持明尼苏达大学的衰老功能蛋白质组学跨学科培训计划。该培训计划包含两个主要组成部分：（1）研究培训，重点是使用蛋白质组学技术来揭示组织功能与年龄相关的损失背后的分子细节。 （2）老年病学和蛋白质组学领域的教学和体验培训，为受训者提供稳固的基础，以启动衰老研究的成功职业。 The research component of this Training Program consists of three research areas that focus on retaining physiological function during aging: muscle (Thomas, Thompson, Lowe, Arriaga, Ervasti), the central nervous system (Olsen, Ferrington, Low, Ervasti) and metabolism and longevity (Bernlohr, Arriaga, Griffin, Hendrickson, Kim, Low).这些计划的教职员工来自明尼苏达大学的两个研究生课程：生物化学，分子生物学和生物物理学（BMBB）和康复科学（RSC）。蛋白质组学分析用于培训教师来揭示蛋白质含量，结合伴侣和老年组织中发生的翻译后修饰的改变。该信息有助于确定与年龄相关的蛋白质结构和功能变化的机理基础。我们的研究得到了配备各种最先进的质谱仪的杰出核心，例如质谱和蛋白质组学中心以及培训教师实验室中的其他分析设备。该培训计划还将包括通过老年学课程和蛋白质组学课程进行教学培训，以及通过研讨会，研讨会，期刊俱乐部和与计划教职员工的小组会议进行老化研究的体验培训。完成培训计划课程的完成将使受训者有资格获得小型毕业生未成年人，从而为受训者的未来职业目标提供了指导。经验训练旨在最大程度地提高学员之间的互动和来自多个实验室的培训教师。总而言之，该培训计划的主要目标是帮助杰出的年轻科学家开发成生产力职业所需的智力和技术工具，成为独立的研究人员和教育工作者的老龄化研究。