Cognitive and Neurobiological Approaches to Plasticity (C-NAP) Center

可塑性认知和神经生物学方法 (C-NAP) 中心

基本信息

批准号：
10197939
负责人：
Kimberly Kirkpatrick
金额：
$ 207.75万
依托单位：
KANSAS STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10197939
关键词：
Adaptive Behaviors Advisory Committees Aging Animal Model Applications Grants Applied Research Area Automobile Driving Award Behavior Behavioral Brain Brain imaging Centers of Research Excellence Cities Climate Cognitive Collaborations Core Facility Coupled Development Discipline Ensure Extramural Activities Faculty Faculty Recruitment Funding Future Goals Grant Growth Health Human Individual Institution Joints Kansas Knowledge Laboratories Lead Life Longevity Maintenance Mentors Mission Missouri Modernization Nature Nebraska Nerve Degeneration Neurobiology Neuronal Plasticity Neurosciences Nevada North Dakota Oklahoma Organism Participant Pathway interactions Pilot Projects Postdoctoral Fellow Process Productivity Program Development Research Research Infrastructure Research Institute Research Personnel Research Project Grants Research Support Research Technics Resources Rewards Rodent Model Secure Seeds Study Section Training Training Programs Translational Research Translations Traumatic Brain Injury United States National Institutes of Health Universities Wichita Work animal imaging cognitive function cognitive process cohesion comparative design disability experience faculty mentor graduate student healthy aging human model improved improved functioning laboratory facility medical schools member multidisciplinary neuroimaging neuroinformatics neuromechanism post-doctoral training programs recruit relating to nervous system success symposium synergism training opportunity

项目摘要

OVERALL PROJECT SUMMARY This COBRE application will form a unique, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (C-NAP). Four primary research projects bridge areas of excellence in the Cognitive and Behavioral Neuroscience programs at Kansas State University (KSU) and the Human Factors program at Wichita State University (WSU). The projects examine cognitive/neural plasticity across the lifespan, utilizing basic and translational/applied approaches in humans and animal models. The ultimate goal is to determine the mechanisms involved in cognitive and neural plasticity to improve functioning. This goal is highly relevant to the NIH core mission “to seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.” Three research core facilities will support the research projects and programs, a Behavioral Neuroscience Core (KSU), a Neuroinformatics Core (KSU), and a Driving Simulator Core (WSU), supplying unique research infrastructure resources within the State of Kansas. The success and growth of C-NAP will be enabled through: (1) a faculty mentoring program that will provide high-quality research mentoring by nationally-recognized researchers. The mentoring team will support all aspects of research program and grant application development to promote success in securing R01-level funding by each of the project leaders; (2) new faculty recruitment at KSU and WSU to ensure growth and longevity of C-NAP and vibrant usage of the core facilities; (3) a pilot grant program that will stimulate center growth by funding projects at universities in the region; (4) a post- doctoral training program that will provide multi-disciplinary training along cross-cutting themes that bridge core facilities and projects, coupled with creating pathways to independence; (5) a scientific exchange network (SEN) that will provide training opportunities and access to additional core facilities with the goal of promoting the research productivity and success of the COBRE core projects, pilot projects, post-doctoral and graduate student trainees, and associated C-NAP faculty. Initial partners include the Hoglund Brain Imaging and K-INBRE centers at the University of Kansas Medical School, COBRE centers at North Dakota State University and the University of Nevada-Reno, the small-animal imaging core at KSU, and the Envision Research Institute in Wichita. The SEN will grow and expand to other nearby universities and research centers (e.g., University of Kansas-Lawrence, University of Missouri-Kansas City, University of Missouri-Columbia, University of Nebraska- Lincoln, the University of Oklahoma, and the Traumatic Brain Injury Unit at Ft. Riley) providing rich opportunities for promoting the growth of research programs. The C-NAP center will host mini-conferences in Years 3 and 5 that will include participants from C-NAP projects, programs, and SEN members to showcase and share research with investigators from outside of the network, promoting the national reputation of C-NAP.

项目总体概要该 COBRE 应用程序将形成一个独特的认知和神经生物学主题研究中心可塑性方法 (C-NAP) 的四个主要研究项目连接了认知领域的卓越领域。堪萨斯州立大学 (KSU) 的行为神经科学项目和人类因素项目威奇托州立大学 (WSU) 的项目利用生命周期中的认知/神经可塑性进行研究。人类和动物模型的基本和转化/应用方法的最终目标是确定。涉及认知和神经可塑性的机制以改善功能。与 NIH 的核心使命相关：“寻求有关生命系统本质和行为的基础知识以及应用这些知识来增强健康、延长寿命、减少疾病和残疾。” 研究核心设施将支持研究项目和计划，即行为神经科学核心 (KSU)、神经信息学核心 (KSU) 和驾驶模拟器核心 (WSU)，提供独特的研究堪萨斯州的基础设施资源将通过以下方式实现 C-NAP 的成功和发展： (1) 教师指导计划，由国家认可的专家提供高质量的研究指导研究人员的指导团队将支持研究计划和资助申请开发的各个方面。促进每位项目负责人成功获得 R01 级资助 (2) 新教师招聘；在肯塔基州立大学和华盛顿州立大学确保 C-NAP 的发展和寿命以及核心设施的活跃使用 (3) 试点；拨款计划将通过资助该地区大学的项目来刺激中心的发展；(4) 博士培训计划将提供跨领域主题的多学科培训核心设施和项目，以及创造独立途径；（5）科学交流网络；（SEN），将提供培训机会和使用额外核心设施的机会，目的是促进 COBRE 核心项目、试点项目、博士后和研究生的研究生产力和成功学生实习生和相关的 C-NAP 教职人员最初的合作伙伴包括 Hoglund Brain Imaging 和 K-INBRE。堪萨斯大学医学院的中心、北达科他州立大学的 COBRE 中心和内华达大学里诺分校、肯塔基州立大学小动物成像核心和远景研究所威奇托 SEN 将发展并扩展到附近的其他大学和研究中心（例如，威奇托大学）堪萨斯劳伦斯大学、密苏里大学堪萨斯城分校、密苏里大学哥伦比亚分校、内布拉斯加大学- 林肯、俄克拉荷马大学和莱利堡创伤性脑损伤科）提供了丰富的机会。为了促进研究项目的发展，C-NAP 中心将在第三年和第五年举办小型会议。其中包括来自 C-NAP 项目、计划的参与者和 SEN 成员，以展示和分享研究成果与网络外部的调查人员合作，提升 C-NAP 的国家声誉。