Cognitive and Neurobiological Approaches to Plasticity (C-NAP) Center

可塑性认知和神经生物学方法 (C-NAP) 中心

• 批准号: 10398612
• 负责人: Kimberly Kirkpatrick
• 金额: $ 11.82万
• 依托单位: KANSAS STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10398612
• 关键词: Adaptive Behaviors; Aging; Amplifiers; Animal Housing; Animal Model; Animals; Applied Research; Area; Award; Back; Behavioral; Brain; Brain imaging; Centers of Research Excellence; Chemistry; Climate; Cognitive; Complex; Consultations; Core Facility; Data; Data Analyses; Data Set; Development; Electroencephalography; Ensure; Equipment; Extramural Activities; Faculty; Faculty Recruitment; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Growth; High Performance Computing; Human; Individual; Institution; Kansas; Laboratories; Link; Longevity; Magnetic Resonance Imaging; Medical center; Modeling; Nerve Degeneration; Neurobiology; Neuronal Plasticity; Neurosciences; Neurosciences Research; North Dakota; Operative Surgical Procedures; Pathway interactions; Performance; Phase; Pilot Projects; Postdoctoral Fellow; Process; Productivity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Research Technics; Resources; Rewards; Speed; Support System; System; Techniques; Technology; Translational Research; Translations; Universities; animal imaging; archive data; cognitive neuroscience; cognitive process; cohesion; comparative; cost; cryostat; data archive; data modeling; data sharing; design; experience; faculty research; human model; improved; improved functioning; laboratory facility; member; neuroimaging; neuroinformatics; neuroregulation; new technology; programs; recruit; relating to nervous system; success; synergism; tenure track; visual neuroscience

PROJECT SUMMARY This Phase 1 COBRE resulted in the establishment of a unique, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (CNAP). Research projects and pilot grants examine cognitive/neural plasticity across the lifespan, utilizing basic and translational/applied approaches in humans and animal models. The ultimate goal is to determine the mechanisms involved in cognitive and neural plasticity to improve functioning. Three research core facilities support the research projects, pilot grants, and programs: a Behavioral Neuroscience Core (BN), an Electroencephalography (EEG) Core, and a Neuroinformatics Core (NI), supplying unique research infrastructure resources within the State of Kansas. The BN core underwent major renovations in 2017 (nearly $1M in total costs) which included facility and equipment upgrades to shared user surgical and wet laboratories. A new cage wash facility was also installed to support increased animal housing capacity. The upgrades enhanced the ability of this core to support cutting-edge animal neuroscience research. This core has supported two projects and one pilot grant and CNAP anticipates funding one project and one pilot grant that will use this core in the coming grant year. The current supplement will enhance this core through the purchase of a new cryostat as an upgrade and eventual replacement for the current outdated unit. All five laboratories that use this core rely heavily on the cryostat and there are insufficient back-up resources on campus, so this upgrade will ensure continuity of research. The EEG core was established in 2018 as a new multi-user core to support human cognitive neuroscience research. This core has supported two pilot grants and a project, and the center anticipates supporting one pilot project and a primary project in the coming grant year that will use this core. This supplement will support a critical upgrade to the current amplifier which is becoming outdated. To expand the functionality of this core, CNAP will purchase a repetitive transmagnetic stimulation system to support neuromodulation research. This represents a significant advancement in the research techniques that the core will be able to support. The NI core was established in 2017 as a new core, tied in with the Beocat high-performance computing facility. This core supports all project and pilot grants and directly interfaces with the EEG core and two other cores in the CNAP scientific exchange network (the Hoglund Brain Imaging Center at the University of Kansas Medical Center and the Small Animal Imaging NMR/MRI Core in Chemistry at K-State). This supplement will upgrade the file system for supporting data-intensive neuroimaging analysis and modeling activities to increase performance by 10,000x over the current general-purpose system. This upgrade will create opportunities to support cutting-edge analysis techniques for all CNAP funded projects and pilot grants. Overall, the upgrades in this supplement provide multi-faceted opportunities to support the success and growth of CNAP to ensure the center supplies high quality equipment and cutting-edge technologies to promote the success of CNAP junior investigators.

项目概要 第一阶段 COBRE 建立了一个独特的认知和认知主题研究中心 可塑性的神经生物学方法（CNAP）。研究项目和试点资助检查认知/神经 整个生命周期的可塑性，利用人类和动物的基本和转化/应用方法 模型。最终目标是确定认知和神经可塑性所涉及的机制 改善功能。三个研究核心设施支持研究项目、试点拨款和计划： 行为神经科学核心 (BN)、脑电图 (EEG) 核心和神经信息学核心 （NI），在堪萨斯州提供独特的研究基础设施资源。 BN 核心经历了 2017 年进行了重大翻修（总成本近 100 万美元），其中包括将设施和设备升级为共享设施 用户外科和湿实验室。还安装了新的笼子清洗设施以支持增加的动物 住房容量。此次升级增强了该核心支持尖端动物神经科学的能力 研究。该核心已支持两个项目和一项试点拨款，CNAP 预计资助一个项目 以及一项试点拨款，将在下一个拨款年度使用该核心。当前的补充将加强这一点 通过购买新的低温恒温器作为升级并最终替换当前过时的低温恒温器来实现核心 单元。使用该核心的所有五个实验室都严重依赖低温恒温器，并且备份不足 校园资源丰富，因此此次升级将确保研究的连续性。 EEG核心成立于 2018年作为新的多用户核心支持人类认知神经科学研究。该核心已支持 两项试点赠款和一个项目，该中心预计支持一项试点项目和一项主要项目 即将到来的资助年将使用这个核心。该补充将支持对当前版本的关键升级 放大器已经过时了。为了扩展该核心的功能，CNAP 将购买重复的 支持神经调节研究的转磁刺激系统。这代表着一个重要的 核心能够支持的研究技术的进步。 NI 核心成立于 2017年作为新核心，与Beocat高性能计算设施捆绑在一起。该核心支持所有项目 和试点拨款，并与 EEG 核心和 CNAP 科学交流中的其他两个核心直接对接 网络（堪萨斯大学医学中心霍格伦德脑成像中心和小动物 K-State 化学领域的成像 NMR/MRI 核心）。本补充将升级文件系统以支持 数据密集型神经影像分析和建模活动，可将性能提高 10,000 倍 当前的通用系统。此次升级将为支持前沿分析创造机会 所有 CNAP 资助的项目和试点补助金的技术。总体而言，本补充中的升级提供了 多方面的机会来支持 CNAP 的成功和发展，以确保该中心提供高水平的供应 优质设备和尖端技术促进 CNAP 初级研究人员的成功。