A pocket-sized device for personal exposure level assessment

用于个人暴露水平评估的袖珍设备

• 批准号: 8658433
• 负责人: Erica Silvia Forzani
• 金额: $ 49.31万
• 依托单位: TF SENSORS, LLC
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-24 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8658433
• 关键词: Address; Air; Air Pollutants; Benzene; Binding; Breathing; Calibration; Carcinogens; Cells; Cellular Phone; Chemical Exposure; Chemicals; Collaborations; Communication; Communities; Computer software; Cosmetics; Coupled; Data; Detection; Development; Devices; Digital Signal Processing; Disease; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Monitoring; Epidemiologist; Equipment; Feedback; Future; Gas Chromatography; Genetic Predisposition to Disease; Goals; Gold; Health Technology; Healthcare; Home environment; Household; Housing; Hybrids; Immune; Individual; Industrial Waste; Industry; Location; Mass Spectrum Analysis; Measures; Mechanics; Methods; Molecular; Monitor; Neighborhoods; Neuraxis; Occupational Safety; Performance; Phase; Polymers; Population Study; Prevention; Production; Protocols documentation; Quartz; Reference Standards; Reporting; Research; Resolution; Sampling; Scheme; Scientist; Specificity; Staging; System; Technology; Telephone; Test Result; Testing; Time; Toluene; Toxic Environmental Substances; Universities; Variant; Wireless Technology; Work; Xylene; abstracting; air sampling; base; commercialization; computerized data processing; cost; empowered; ethylbenzene; imprint; improved; innovation; miniaturize; new technology; novel; operation; prototype; remediation; sample collection; sensor; tool; toxicant; trafficking; transmission process; usability; user-friendly; volatile organic compound

DESCRIPTION (provided by applicant): A pocket-sized device for personal exposure level assessment! Abstract Detecting environmental toxicants is critical for better understanding of the relationship between chemical exposures and many diseases, and for more effective prevention of the related diseases. Due to large variations in the individuals' genetic susceptibility and environmental exposure level, an ideal detection tool must be miniaturized, affordable and personalized so that it can measure the toxicants in real time and within each individual's breathing zone. Except for a few selected analytes, the current approach is to collect air samples at a certain location and time, and transport the samples to a lab for detailed analysis using sophisticated but expensive and difficult-to-operate equipment, such as gas chromatography coupled with mass spectrometry. The goal of the present project is to address the above need by introducing a new sensor technology, focusing on harmful analytes, such as carcinogens, which are important but currently not covered by any of the existing portable devices. The sensor technology is based on an innovative hybrid principle that combines intelligent sampling and separation mechanisms with a sensitive microfabricated quartz tuning fork array and selective molecular imprinted polymer sensing materials to achieve high specificity and high sensitivity with a miniaturized device. The device is pocket-sized and contains a Bluetooth chip that communicates wirelessly with cell phones or other Bluetooth-enabled devices. The new technology will provide unprecedented high temporal and high spatial resolutions for personal environmental exposure monitoring, which will benefit a large environmental health research community, support ongoing and future large-scale population studies, and impact on industrial and occupational safety and environmental monitoring. The team will develop, build and test the device in phase I. They will validate it with established collaborations, including epidemiologists, industry hygienists, occupational safety professionals and environmental scientists, and prepare for production of the device in phase II.

描述（由申请人提供）：用于个人暴露水平评估的袖珍设备！摘要 检测环境毒物对于更好地了解化学品暴露与许多疾病之间的关系以及更有效地预防相关疾病至关重要。由于个体的遗传易感性和环境暴露水平存在很大差异，理想的检测工具必须小型化、价格实惠且个性化，以便能够在每个人的呼吸区内实时测量有毒物质。除了一些选定的分析物外，目前的方法是收集 在特定地点和时间采集空气样本，并将样本运送到实验室，使用复杂但昂贵且难以操作的设备（例如气相色谱法与质谱法）进行详细分析。本项目的目标是通过引入新的传感器技术来满足上述需求，重点关注有害分析物，例如致癌物，这些分析物很重要，但目前任何现有便携式设备均未涵盖。该传感器技术基于创新的混合原理，将智能采样和分离机制与灵敏的微加工石英音叉阵列和选择性分子印迹聚合物传感材料相结合，通过小型化设备实现高特异性和高灵敏度。该设备是袖珍型的，包含一个蓝牙芯片，可以与手机或其他支持蓝牙的设备进行无线通信。 这项新技术将为个人环境暴露监测提供前所未有的高时间和高空间分辨率，这将有利于大型环境健康研究界，支持正在进行和未来的大规模人口研究，并对工业和职业安全和环境监测产生影响。该团队将在第一阶段开发、构建和测试该设备。他们将与流行病学家、工业卫生学家、职业安全专业人员和环境科学家等既定合作伙伴进行验证，并为第二阶段的设备生产做准备。