Mobile multifunctional tool for monitoring and management of respiratory diseases

用于监测和管理呼吸系统疾病的移动多功能工具

基本信息

批准号：
9262272
负责人：
Erica Silvia Forzani
金额：
$ 47.46万
依托单位：
TF HEALTH CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-04-16 至 2020-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9262272
关键词：
Acoustics Affect Algorithms Alpha Cell American Asthma Back Breath Tests Businesses Capnography Carbon Dioxide Cellular Phone Certification Chest Chronic Chronic Obstructive Airway Disease Clinic Clinical Clinics and Hospitals Communication Computer software Current Procedural Terminology Codes Data Display Data Storage and Retrieval Detection Development Devices Diagnosis Discrimination Disease Electromagnetics Equipment Gases Goals Guidelines Health Health Status Health Technology Hospitals Humidity Immune Industry Insurance Light Lighting Lung diseases Marketing Measurement Measures Medical Medical Device Medical center Monitor Patient Monitoring Patients Performance Phase Population Production Protocols documentation Quality Control Reaction Time Receiver Operating Characteristics Risk Assessment Safety Sales Sampling Sensitivity and Specificity Societies Spirometry Supervision Technology Temperature Test Result Testing Wireless Technology Work asthmatic patient consumer product cost design effective therapy handheld mobile device innovation instrument mHealth meetings nanocomposite pressure public health relevance pulmonary function quality assurance sensor signal processing success tool usability user-friendly verification and validation

项目摘要

DESCRIPTION (provided by applicant): Mobile multifunctional tool for monitoring and management of respiratory diseases Chronic Obstructive Pulmonary Disease (COPD) and asthma affect millions of people worldwide. Because there is no permanent cure for these diseases, efficient management of the patients is needed. New mobile health technologies, such as personal devices that allow patients to monitor their diseases under or near free- living conditions, will lower the cost, and thus contribute to the solution of the problem. Furthermore, continuous monitoring of the patients' health status afforded by the mobile devices will provide more complete information than the sporadic medical exams carried out currently in hospital or clinical settings. The most effective diagnosis and management technologies for COPD and asthma are spirometry and capnography. However, traditional low-cost spirometers are relatively inaccurate and lack of gas exchange information, and the capnography equipment is bulky, expensive, and difficult-to-operate without close supervision of professionals. These factors have limited spirometry and capnography to the use in hospital or clinic setting only. The present project aims at developing a personal device that can perform both capnography and spirometry for patients to use outside of hospitals and clinics. Creating such a device has been a challenge. To overcome the challenge, the Phase 1 part of the project has successfully developed and validated several innovations, including 1) a nanocomposite sensing material for accurate breath-by- breath analysis of carbon dioxide concentrations, 2) a low cost and high performance acoustic flow sensor that covers a wide dynamic range for both low flow-rate capnography and high flow-rate spirometry, 3) an adaptive sampling algorithm for correctly collecting the patient's breath without the presence of professionals, and 4) a cell phone application for signal processing. Building upon the success of Phase 1, this Phase 2 project will transform the technology into a real world solution for COPD and asthma patients by designing, building and testing a complete device with cell phone App, establishing manufacturing protocols, and preparing a FDA application. The project will bring together strengths of the sensor development and device fabrication at TF Health Co (doing business as Breezing Co.), sensor characterization and testing team at ASU, and clinical expertise of Banner Good Samaritan Medical Center to achieve the goal. The team has worked together and completed all the milestones in Phase 1, and is ready to overcome technical challenges and to develop the first wireless device with both spirometry and capnography capabilities.

描述（由申请人提供）：用于监测和管理呼吸系统疾病的移动多功能工具慢性阻塞性肺病（COPD）和哮喘影响着全世界数百万人，因为这些疾病没有永久治愈方法，因此需要对患者进行有效管理。新的移动医疗技术，例如允许患者在自由生活条件下或接近自由生活条件下监测其疾病的个人设备，将降低成本，从而有助于解决问题，此外，还可以对患者的健康状况进行持续监测。通过手机与目前在医院或临床环境中进行的零星医疗检查相比，这些设备将提供更完整的信息。慢性阻塞性肺病和哮喘最有效的诊断和管理技术是肺活量测定法和二氧化碳图。然而，传统的低成本肺活量计相对不准确且缺乏气体。交换信息，并且二氧化碳图设备体积庞大、昂贵且在没有专业人员的密切监督下难以操作。这些因素限制了肺活量测定法和二氧化碳图仅在医院或诊所环境中使用。能够为患者在医院和诊所外使用的个人设备进行二氧化碳监测和肺活量测定是一项挑战，为了克服这一挑战，该项目的第一阶段已成功开发并验证了多项创新，其中包括： ) 一种纳米复合传感材料，用于准确分析每次呼吸的二氧化碳浓度，2) 一种低成本、高性能声学流量传感器，涵盖低流速二氧化碳图和高流速肺活量测定的宽动态范围， 3) 无需专业人员即可正确采集患者呼吸的自适应采样算法，以及 4) 用于信号处理的手机应用程序在第一阶段的成功基础上，第二阶段项目将将该技术转变为现实世界的解决方案。通过使用手机应用程序设计、构建和测试完整的设备、建立制造协议以及准备 FDA 申请，该项目将汇集 TF Health Co 的传感器开发和设备制造的优势（以 . Breezing Co.），传感器亚利桑那州立大学的表征和测试团队以及班纳好撒玛利亚医疗中心的临床专业知识为实现这一目标该团队共同努力，完成了第一阶段的所有里程碑，并准备好克服技术挑战并开发首款无线设备。肺活量测定和二氧化碳图功能。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A New Differential Pressure Flow Meter for Measurement of Human Breath Flow: Simulation and Experimental Investigation.

用于测量人体呼吸流量的新型差压流量计：模拟和实验研究。

DOI：
发表时间：
2016-03
期刊：
影响因子：
0
作者：
Bridgeman, Devon;Tsow, Francis;Xian, Xiaojun;Forzani, Erica
通讯作者：
Forzani, Erica

Mitigation of Data Packet Loss in Bluetooth Low Energy-Based Wearable Healthcare Ecosystem.

减少基于蓝牙低能耗的可穿戴医疗生态系统中的数据包丢失。

DOI：
发表时间：
2021-09-23
期刊：
影响因子：
0
作者：
Tipparaju, Vishal Varun;Mallires, Kyle R;Wang, Di;Tsow, Francis;Xian, Xiaojun
通讯作者：
Xian, Xiaojun

Wearable Transcutaneous CO2 Monitor Based on Miniaturized Nondispersive Infrared Sensor.

基于小型化非色散红外传感器的可穿戴经皮二氧化碳监测仪。

DOI：
发表时间：
2021-08-01
期刊：
影响因子：
4.3
作者：
Tipparaju, Vishal Varun;Mora, Sabrina Jimena;Yu, Jingjing;Tsow, Francis;Xian, Xiaojun
通讯作者：
Xian, Xiaojun

Reliable Breathing Tracking with Wearable Mask Device.

使用可穿戴面罩设备进行可靠的呼吸跟踪。

DOI：
发表时间：
2020-05-15
期刊：
影响因子：
4.3
作者：
Tipparaju, Vishal Varan;Xian, Xiaojun;Bridgeman, Devon;Wang, Di;Tsow, Francis;Forzani, Erica;Tao, Nongjian
通讯作者：
Tao, Nongjian

A Miniaturized Particulate Matter Sensing Platform based on CMOS imager and Real Time Image Processing.

基于 CMOS 成像仪和实时图像处理的小型化颗粒物传感平台。