Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across Adolescence

早期生活压力与青春期抑郁之间关联的心理生物学机制

基本信息

批准号：
10749429
负责人：
IAN H GOTLIB
金额：
$ 75.37万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-01 至 2028-02-29
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10749429
关键词：
13 year old 9 year old Address Adolescence Adolescent Adult Adverse effects Affect Age Air Pollutants Award Behavior assessment Behavioral Biological Biological Aging Blood Brain COVID-19 COVID-19 impact COVID-19 pandemic COVID-19 pandemic effects Cause of Death Child Childhood Clinical Cognitive Cohort Studies Collaborations Complement Data Data Analytics Data Set Development Diagnosis Dimensions Disease Endocrine Environmental Exposure Environmental Pollutants Equation Exposure to Family Grant Health Immunologics Interview Life Life Cycle Stages Machine Learning Measurement Measures Mental Depression Mental Health Modeling Not Hispanic or Latino Outcome Paper Parents Participant Persons Physiology Predictive Factor Prevention Prevention program Prospective Studies Psychopathology Publishing Quarantine Rewards Risk Risk Factors Saliva Sampling Series Severities Singapore Specimen Stress Stressful Event Suicide attempt Symptoms Techniques Testing United States National Institutes of Health Work Youth boys cohort coronavirus disease deprivation early life adversity early life stress economic disparity experience girls health disparity populations high risk large datasets longitudinal dataset neural neurodevelopment neuroimaging pandemic disease prenatal promote resilience psychobiologic psychosocial public health relevance racial population recruit resilience resilience factor risk prediction southeast Asian stress reactivity suicidal behavior treatment program young adult

项目摘要

Abstract More than 50% of youth will experience at least one form of significant adversity in early life. Such adversities pose significant risk not only for the development of psychopathology over the life course, but also for attempted suicide, a leading cause of death in people ages 10-24 years. We have recruited and assessed 220 9- to 13-year-old boys and girls across four timepoints, each two years apart, to examine the effects of exposure to ELS on trajectories of stress reactivity and reward sensitivity, and, in turn, their impact on the onset of psychopathology and suicidal behaviors across adolescence. In this cohort we have conducted repeated measurements of symptoms and diagnoses of psychopathology, neural, endocrine, cognitive, immunological, and behavioral assessments of stress reactivity and reward sensitivity, and early exposure to adversity, including the type, severity, and timing of stressful events. We have published a series of papers from this project elucidating the effects of ELS on psychobiological functioning, trajectories of brain development, and biological aging, and the consequences of these alterations for clinical functioning. In this MERIT renewal application, we propose to build on and extend our work in three important ways. First, we will conduct an additional assessment of our participants at age 20 in order to examine the effects of ELS on trajectories of neurodevelopment and clinical outcomes from childhood to young adulthood, as well as the persistence of COVID-19 pandemic-related difficulties in mental health, stress, and brain metrics. We will also extend our examination of how environmental pollutants and conditions affect relations among these variables. Second, we will extend and replicate our findings in a younger, non-Western sample by analyzing data from the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) project, an ongoing prospective study in which many of the same, or comparable, measures that we administered in our project have also been collected regularly from approximately 1,500 parents and children since the prenatal period. Extending and replicating our findings with the GUSTO dataset, which includes younger, non-Western children from Southeast Asian families in Singapore, will complement findings from other large cohorts, like ABCD and NCANDA, that have assessed only Western participants. Finally, will leverage our own and GUSTO data to examine the effects of the COVID-19 pandemic shutdown on children’s and adolescents’ psychobiological functioning. In both datasets we have a unique opportunity to compare comprehensive psychobiological data collected from the same youth before and after the pandemic shutdowns in order not only to examine how the pandemic has altered young people’s psychobiological functioning and development, but importantly, to also identify risk and resilience factors across cultural contexts. Further, the new proposed adult assessment in our ELS project will allow us to examine the persistence of COVID-related difficulties by re-assessing participants whom we studied soon after pandemic quarantine restrictions ended.

抽象的超过 50% 的青少年在早年经历过至少一种形式的重大逆境。逆境不仅对生命过程中精神病理学的发展构成重大风险，而且我们招募并评估了自杀未遂的情况，自杀是 10 至 24 岁人群死亡的主要原因。 220 名 9 至 13 岁的男孩和女孩在四个时间点（每个时间点相隔两年）进行研究，以检验暴露于 ELS 对压力反应性和奖励敏感性轨迹的影响，以及它们对在这个队列中，我们进行了青春期精神病理学和自杀行为的发作。重复测量症状并进行精神病理学、神经、内分泌、认知、应激反应性和奖赏敏感性的免疫学和行为评估，以及早期暴露逆境，包括压力事件的类型、严重程度和发生时间。我们发表了一系列论文。该项目阐明了 ELS 对心理生物学功能、大脑轨迹的影响发育、生物衰老，以及这些改变对临床功能的影响。对于 MERIT 续签申请，我们建议通过三个重要方式来巩固和扩展我们的工作。对 20 岁时的参与者进行额外评估，以检查 ELS 对从儿童期到青年期的神经发育轨迹和临床结果，以及与 COVID-19 大流行相关的心理健康、压力和大脑指标方面的困难持续存在。扩大我们对环境污染物和条件如何影响这些变量之间关系的研究。其次，我们将通过分析来自以下国家的数据，在更年轻的非西方样本中扩展和复制我们的发现：新加坡成长迈向健康成果 (GUSTO) 项目，这是一项正在进行的前瞻性研究我们在项目中实施的许多相同或类似的措施也已得到实施自产前期以来定期从大约 1,500 名父母和儿童那里收集。使用 GUSTO 数据集复制我们的发现，其中包括来自以下国家的年轻非西方儿童新加坡的东南亚家庭将补充其他大型群体的研究结果，例如 ABCD 和 NCANDA 仅评估了西方参与者，最后将利用我们自己和 GUSTO 的数据来进行评估。检查 COVID-19 大流行关闭对儿童和青少年心理生物学的影响在这两个数据集中，我们有一个独特的机会来比较全面的心理生物学数据。在大流行关闭之前和之后从同一位年轻人那里收集数据，不仅是为了研究大流行影响了年轻人的心理生物学功能和发展，但重要的是，也影响了年轻人的心理生物学功能和发展此外，我们还提出了新的成人评估方案。 ELS 项目将使我们能够通过重新评估参与者来检查与新冠病毒相关的困难的持续存在大流行隔离限制结束后不久我们就研究了谁。