Wearable sensor for passive detection and efficient treatment of multiple disorders

用于被动检测和有效治疗多种疾病的可穿戴传感器

• 批准号: 9978052
• 负责人: Erica Silvia Forzani
• 金额: $ 7.24万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2021-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9978052
• 关键词: Acetone; Adhesives; Algorithms; Anorexia; Arizona; Biological Markers; Biosensor; Blood; Bluetooth; Body Weight; Body Weight Changes; Body Weight decreased; Breath Tests; Calibration; Cardiovascular Diseases; Cellular Phone; Clinical; Clinical Research; Code; Communities; Computer software; Data; Detection; Development; Devices; Diabetes Mellitus; Diagnosis; Disease; Disease Management; Eating; Eating Behavior; Eating Disorders; Effectiveness; Ensure; Epilepsy; Evaluation; Exercise; FDA approved; Family; Fatty acid glycerol esters; Feedback; Food; Future; High Fat Diet; Hybrids; Individual; Industry; Insulin-Dependent Diabetes Mellitus; Intelligence; Intervention; Ketones; Ketosis; Kidney; Lead; Liver; Malignant Neoplasms; Measurement; Medical; Medicine; Membrane; Mental disorders; Metabolic Diseases; Methods; Modern Medicine; Monitor; Names; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Obsession; Overweight; Patient Monitoring; Patients; Pattern; Performance; Persons; Physiology; Pilot Projects; Process; Readiness; Recording of previous events; Research Personnel; Risk; Safety; Scheme; Science; Shapes; Skin; Specialist; Tablets; Testing; Time; Underweight; Universities; Urine; Validation; Weight; Weight maintenance regimen; Work; base; college; data acquisition; excessive weight gain; flexibility; flexible electronics; healthy weight; industry partner; intelligent algorithm; monitoring device; mortality; oxidation; prototype; sensor; sensor technology; signal processing; time use; tool; transmission process; usability; wearable sensor technology

Abstract The ability to maintain a healthy body weight has become an increasingly common roadblock in modern medicine as extreme high or low weight can lead to and aggravate existing medical conditions. Achieving a healthy weight is often difficult for those who are overweight, obese or underweight since a great deal of food intake and exercise tracking is usually a requirement for effective weight targets. The accuracy and effectiveness of this process could be increased drastically if a real-time fat oxidation biomarker monitoring device were available. Recent clinical studies of fat oxidation by the team and others have demonstrated the importance of ketones as biomarkers with a great opportunity for those patients who need proactively concrete weight management interventions. In addition to eating disorders, conditions related to ketoacidosis, which is a well-known risk state for type 1 diabetes, or ketosis state, a high ketone level state induced by low carb / high fat diets used to manage several diseases (such as epilepsy, type 2 diabetes, cancer among many others) are in need of close ketone monitoring. Although ketones are FDA approved fat oxidation biomarkers, there are relatively few ketone-based sensors available for consumer use. Those that do exist are based on blood, urine and breath test and are one-point-in-time use, sometime inaccurate, or far too invasive for everyday use. As a result, a huge need exists for the development of a passive and non-invasive ketone sensor. One possible solution is to develop a sensor that displays real time data regarding the wearer’s fat oxidation by tracking the acetone permeated through the skin of the sensor’s wearer. Researchers at Arizona State University (ASU) have developed a sensor technology for passive detection of acetone that has shown accurately monitoring acetone. However, extensive work is necessary to complete the sensor optimization to sense skin acetone, and integrate the sensor into a wearable. The team of researchers at ASU will work on the necessary tasks to create a prototype for testing in a pilot study. A medical science expert team at University of Arizona (UA) will work together with the sensor team to develop the first prototype. The sensor group at ASU will develop, optimize, build and test the wearable sensor analyzer. Meanwhile, the clinical experts at UA and industry partners at 3M Company will assure industry quality standards requirements, and provide feedback in the device and its user interface. The analyzer brings an unprecedented opportunity for weight and multiple disease management, since not only overcomes current barriers from existing ketone sensors, but also eliminates the patient’s burden of current approaches, which require personal tracking of weight, food intake and activity, while providing timely intervention feedback.

抽象的 保持健康体重的能力已成为现代人越来越常见的障碍 体重过高或过低会导致并加重现有的医疗状况。 对于超重、肥胖或体重不足的人来说，保持健康的体重通常很困难，因为大量的食物 摄入量和运动跟踪通常是有效体重目标的要求。 如果实时脂肪氧化生物标志物监测，该过程的有效性可以显着提高 该团队和其他人最近对脂肪氧化的临床研究已经证明了这一点。 酮作为生物标志物的重要性，对于那些需要主动具体治疗的患者来说是一个很好的机会 除了饮食失调之外，还有与酮症酸中毒相关的疾病。 众所周知的 1 型糖尿病风险状态，或酮症状态，由低碳水化合物/高碳水化合物引起的高酮水平状态 用于控制多种疾病（例如癫痫、2型糖尿病、癌症等）的脂肪饮食 需要密切酮监测。 尽管酮类是 FDA 批准的脂肪氧化生物标志物，但基于酮类的生物标志物相对较少 可供消费者使用的传感器是基于血液、尿液和呼气测试的。 单一时间点使用，有时不准确，或者对于日常使用来说过于侵入性，因此存在巨大的需求。 存在用于开发被动和非侵入性酮传感器的一种可能的解决方案是开发一种。 传感器通过跟踪渗透的丙酮来显示有关佩戴者脂肪氧化的实时数据 通过传感器佩戴者的皮肤。 亚利桑那州立大学 (ASU) 的研究人员开发了一种无源传感器技术 丙酮检测已表明可以准确监测丙酮，但还需要开展大量工作。 完成传感器优化以感知皮肤丙酮，并将传感器集成到可穿戴设备中。 亚利桑那州立大学的研究人员将致力于创建用于试点研究 A 测试的原型。 亚利桑那大学（UA）医学专家团队将与传感器团队合作开发 亚利桑那州立大学的传感器小组将开发、优化、构建和测试可穿戴传感器的第一个原型。 同时，UA的临床专家和3M公司的行业合作伙伴将为行业提供保证。 质量标准要求，并在设备及其用户界面中提供反馈。 体重和多种疾病管理的前所未有的机会，因为不仅克服了当前 消除了现有酮传感器的障碍，同时也消除了患者目前方法的负担，这 需要个人跟踪体重、食物摄入量和活动，同时提供及时的干预反馈。

项目成果

A Novel Acetone Sensor for Body Fluids.

一种新型体液丙酮传感器。

• 发表时间: 2023-12-22
• 作者: Osorio Perez, Oscar;Nguyen, Ngan Anh;Hendricks, Asher;Victor, Shaun;Mora, Sabrina Jimena;Yu, Nanxi;Xian, Xiaojun;Wang, Shaopeng;Kulick, Doina;Forzani, Erica
• 通讯作者: Forzani, Erica

Comparative study of a novel portable indirect calorimeter to a reference breath-by-breath instrument and its use in telemedicine settings.

新型便携式间接热量计与参考呼吸仪器的比较研究及其在远程医疗环境中的使用。

• 发表时间: 2021-12
• 影响因子: 3
• 作者: Mora, S Jimena;Sprowls, Mark;Tipparaju, Vishal V;Wheatley;Kulick, Doina;Johnson, Bruce;Xiaojun, Xian;Forzani, Erica
• 通讯作者: Forzani, Erica

A Smart System for the Contactless Measurement of Energy Expenditure.

用于非接触式能源消耗测量的智能系统。

• 发表时间: 2022-02-10
• 作者: Sprowls, Mark;Victor, Shaun;Mora, Sabrina Jimena;Osorio, Oscar;Pyznar, Gabriel;Destaillats, Hugo;Wheatley;Johnson, Bruce;Kulick, Doina;Forzani, Erica
• 通讯作者: Forzani, Erica

Total Iron Measurement in Human Serum With a Novel Smartphone-Based Assay.

使用基于智能手机的新型检测方法测量人体血清中的总铁。

• 发表时间: 2020
• 作者: Serhan, Michael;Jackemeyer, David;Long, Mindy;Sprowls, Mark;Diez Perez, Ismael;Maret, Wolfgang;Chen, Fang;Tao, Nongjian;Forzani, Erica
• 通讯作者: Forzani, Erica

An Unobstructive Sensing Method for Indoor Air Quality Optimization and Metabolic Assessment within Vehicles.

用于车内室内空气质量优化和代谢评估的无阻碍传感方法。

• 发表时间: 2020-12-16
• 作者: Deng, Yue;Sprowls, Mark;Mora, S Jimena;Kulick, Doina;Tao, Nongjian;Destaillats, Hugo;Forzani, Erica
• 通讯作者: Forzani, Erica