Center For Urban Responses to Environmental Stressors (CURES)

城市环境压力应对中心 (CURES)

基本信息

批准号：
8619364
负责人：
Melissa A Runge-Morris
金额：
$ 71.2万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-05 至 2017-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8619364
关键词：
Address Adult Affect Animals Basic Science Bioinformatics Biological Markers Blood Chemicals Child Chronic Cities Collaborations Communities Community Outreach Complex Core Facility Development Disease Elderly Environment Environmental Exposure Environmental Health Environmental Illness Environmental Policy Environmental Pollutants Environmental Risk Factor Epidemiology Epigenetic Process Exposure to Fostering Gene Expression Genes Genetic Genomics Goals Health Health Sciences Heart Human Immigrant Immune System Diseases Immune system Individual Interest Group Leadership Learning Life Malignant Neoplasms Mental Health Mentors Metabolic Diseases Metabolism Modeling Molecular Profiling Monitor Neonatal Nutritional status Pathogenesis Persons Pilot Projects Policies Policy Maker Population Population Heterogeneity Predisposition Process Proteomics Public Health Quality of life Refugees Research Research Personnel Research Project Grants Resources Risk Role Science Scientist Services Spottings Testing Toxic Environmental Substances Toxicant exposure Translational Research Universities Vulnerable Populations Work Workplace base biobank career career development combat community based participatory research cost effective disorder prevention disorder risk emergency service responder environmental chemical environmental stressor epigenomics health science research human stem cells human tissue improved induced pluripotent stem cell interest intervention program low socioeconomic status member multidisciplinary next generation novel programs psychosocial public health relevance research study response skills social stressor urban public health

项目摘要

DESCRIPTION (provided by applicant) Situated in the heart of Detroit, the Wayne State University "Center for Urban Responses to Environmental Stressors" (CURES) is focused on understanding how exposures to stressors that are prevalent in the urban industrialized environment, both chemical and non-chemical, impact human health. Special emphasis is placed on life windows of heightened susceptibility to environmental exposure and vulnerable persons at risk for environmental disease (e.g., children and adults of low socio-economic status, older adults, immigrants, refugees, and first responders). The hypothesis of the CURES Center is that diseases that compromise the quality of life in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which include chronic low-level toxicant exposures as well as psycho-social and physical stressors, that re-program key cellular regulatory networks to favor pathogenesis. Four disease-oriented research interest groups serve as interdisciplinary hubs for population and basic scientists and community members interested in the role of environmental exposure in 1) immune disorders, 2) metabolic disease, 3) cancer, and 4) mental health disturbances. The Transdisciplinary/Translational Integration team (TRANSIT) works with community advisors to apply an integrated transdisciplinary approach to solving environmental health problems. The Integrative Health Sciences Facility Core guides Center researchers transitioning toward translational research studies and provides stem cell and human biospecimen services. The Exposure Signatures Facility Core enables Center members to apply integrated, state-of-the-art genomic, epigenomic, proteomic, and bioinformatic strategies to environmental health science research. The Community Outreach and Engagement Core provides for bi-directional exchange between the urban community at risk for environmental illness and Center members. CURES also sponsors programs focused on career and new project development. The CURES Center is a dynamic transdisciplinary research team that is dedicated to environmental disease prevention and creating a cleaner and healthier living and working environment in the city of Detroit.

描述（由申请人提供）韦恩州立大学“城市环境压力应对中心”(CURES) 位于底特律市中心，致力于了解城市工业化环境中普遍存在的化学和非化学压力源如何影响人类健康。特别强调对环境暴露高度敏感的生命窗口和面临环境疾病风险的弱势群体（例如社会经济地位较低的儿童和成人、老年人、移民、难民和急救人员）。 CURES 中心的假设是，在底特律等工业化城市环境中，损害生活质量的疾病是个体遗传和表观遗传构成、营养状况和环境压力源之间动态相互作用的结果，包括长期低水平有毒物质暴露以及心理社会和身体压力源，这些压力源重新编程关键的细胞调节网络以有利于发病机制。四个以疾病为导向的研究兴趣小组作为人口和基础科学家和社区成员的跨学科中心，他们对环境暴露在 1) 免疫疾病、2) 代谢疾病、3) 癌症和 4) 心理健康障碍中的作用感兴趣。跨学科/转化整合团队 (TRANSIT) 与社区顾问合作，应用综合跨学科方法来解决环境健康问题。综合健康科学设施核心指导中心研究人员转向转化研究，并提供干细胞和人类生物样本服务。暴露特征设施核心使中心成员能够将综合的、最先进的基因组、表观基因组、蛋白质组和生物信息学策略应用于环境健康科学研究。社区外展和参与核心为面临环境疾病风险的城市社区和中心成员之间提供了双向交流。 CURES 还赞助专注于职业和新项目开发的计划。 CURES中心是一个充满活力的跨学科研究团队，致力于环境疾病预防以及在底特律市创造更清洁、更健康的生活和工作环境。