Center for Urban Responses to Environmental Stressors (CURES)

城市环境压力应对中心 (CURES)

基本信息

批准号：
9904628
负责人：
Melissa A Runge-Morris
金额：
$ 149.21万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-05 至 2022-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9904628
关键词：
Abate Address Adult Adverse effects Affect Age Age Distribution Air Pollution Area Asthma Awareness Cardiovascular Diseases Characteristics Chemical Exposure Chemicals Child Cities Coke Collaborations Communities Complex Core Facility Development Diabetes Mellitus Disasters Disease Early Diagnosis Elderly Environment Environmental Exposure Environmental Health Environmental Impact Environmental Policy Epidemiology Epigenetic Process Ethnic Origin Exposure to Floor Funding Generations Genetic Geography Goals Health Heart Heart Diseases Heavy Metals Housing Human Immigrant Immune System Diseases Individual Industrialization Lead Lead Poisoning Leadership Light Link Liver diseases Locales Malignant Neoplasms Mentors Metabolic Diseases Michigan Microbiology Mission Modernization National Institute of Environmental Health Sciences Neighborhoods Nutritional status Obesity Particulate Pathogenesis Personal Behavior Personal Satisfaction Petroleum Pilot Projects Policies Policy Maker Pollution Population Heterogeneity Positioning Attribute Prevention Quality of life Race Refugees Renaissance Research Research Personnel Research Training Respiration Disorders Risk Role Science Scientist Secure Seeds Silicon Dioxide Social Interaction Source Strategic Planning Tars Universities Vision Vulnerable Populations Water Work base career consumer product cost design diet and exercise empowered environmental chemical environmental stressor ethnic diversity ethnic minority population experience gene environment interaction health disparity innovation land use lead exposure low socioeconomic status member pollutant programs psychosocial racial diversity resilience response socioeconomics stressor wasting

项目摘要

Situated in the heart of Detroit, the environmental health sciences “identity” of the Center for Urban Responses to Environmental Stressors (CURES) is to understand the health impacts of environmental exposures to complex chemical and non-chemical contaminants in Detroit's urban landscape. Our strategic vision is to provide leadership to identify, evaluate, and mitigate environmental health concerns in close collaboration with the community and environmental policy makers. CURES has assembled a unique interdisciplinary team of established and new environmental health scientists and community partners to address major environmental health challenges facing Detroit's racially and ethnically diverse population. We hypothesize that “modern-era” diseases (e.g., cardiovascular disease, cancer, diabetes) that compromise the quality of life of residents living in an industrialized urban environment, such as Detroit, occur as a consequence of dynamic interactions among an individual's genetic and epigenetic make-up, nutritional status, and environmental stressors, which re-program key cellular networks to favor pathogenesis. CURES advances the NIEHS 2012-2017 Strategic Plan by nurturing strong bonds with Detroit's urban community, applying translational and interdisciplinary team-research approaches to solve complex environmental health problems, and by seeking the sources of environmental health disparities. CURES is making an impact in our region. Our researchers and community partners responded rapidly and coordinately to a serious emerging health crisis in our immediate vicinity; the 2015-2016 lead watershed contamination disaster in Flint, Michigan. To create a gateway to a healthy Detroit, CURES' short-term goals are to: 1) strengthen existing partnerships and continue to develop new ones between CURES and the Detroit community; 2) in collaboration with them, identify the chief environmental health threats to Detroit's vulnerable populations; 3) conduct highly integrated mechanistic, epidemiological, and community-engaged research that addresses the impact of urban environmental exposures on human health; 4) build the capacity of CURES to accomplish its research goals by providing facility cores that are optimized to meet the needs of its members and seed funds to support pilot projects to explore the feasibility of new areas of study; and 5) enhance the impact of CURES on the field of environmental health science by providing mentoring to new and established investigators that supports their professional goals and prepares them for leadership roles in environmental health research. Our long-term goals are to 1) enhance our community partners' efforts to increase community awareness and facilitate programs for a healthier community and 2) develop appropriate strategies, based on CURES research, to inform policy so as to mitigate the risks associated with urban environmental exposures. We believe that CURES is optimally positioned on "the ground floor" of innovative team science opportunities that have the greatest promise to realize the early detection, prevention, and eventual eradication of urban environmental disease in our lifetime.

城市响应中心的环境健康科学“身份”位于底特律市中心环境压力源 (CURES) 的目的是了解环境暴露对健康的影响我们的战略愿景是消除底特律城市景观中的复杂化学和非化学污染物。与以下机构密切合作，领导识别、评估和减轻环境健康问题 CURES 组建了一支由社区和环境政策制定者组成的独特的跨学科团队。已建立和新的环境健康科学家和社区合作伙伴，以解决重大环境问题底特律的种族和民族多元化人口面临的健康挑战我们追求“现代”。影响居民生活质量的疾病（例如心血管疾病、癌症、糖尿病）在底特律等工业化城市环境中，这是动态相互作用的结果个体的遗传和表观遗传组成、营养状况和环境压力因素，重新编程关键细胞网络以有利于发病机制。通过培养与底特律城市社区的牢固联系、应用转化和跨学科进行规划解决复杂环境健康问题的团队研究方法，并通过寻找 CURES 正在对我们地区的研究人员和社区产生影响。合作伙伴对我们附近新出现的严重健康危机做出了迅速、协调的反应； 2015-2016 年密歇根州弗林特发生流域污染灾难为了打造通向健康底特律的门户， CURES 的短期目标是： 1) 加强现有合作伙伴关系并继续发展新的合作伙伴关系 CURES 和底特律社区之间；2) 与他们合作，确定主要环境底特律弱势群体的健康威胁；3) 进行高度综合的机械、流行病学、以及社区参与的研究，解决城市环境暴露对人类的影响 4) 通过提供以下设施核心来建设 CURES 实现其研究目标的能力：优化满足会员需求和种子资金支持试点项目的可行性探索新的研究领域；5) 通过以下方式增强 CURES 对环境健康科学领域的影响：为新的和已建立的研究人员提供指导，支持他们的职业目标并做好准备我们的长期目标是：1) 增强我们在环境健康研究中的领导作用。社区合作伙伴努力提高社区意识并促进更健康的计划社区；2) 根据 CURES 研究制定适当的策略，为政策提供信息，以便我们认为 CURES 是减轻与城市环境暴露相关的风险的最佳选择。位于创新团队科学机会的“底层”，这些机会最有希望实现在我们有生之年尽早发现、预防并最终消除城市环境病。