Thalamocortical interactions

丘脑皮质相互作用

• 批准号: 9914135
• 负责人: S. Murray SHERMAN
• 金额: $ 34.56万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2021-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9914135
• 关键词: Address; Affect; Alzheimer' s Disease; Animals; Area; Attention; Auditory; Automobile Driving; Binding; Biological Models; Cell Nucleus; Cells; Cognitive deficits; Data; Feedback; In Vitro; Inferior; Link; Medial; Modeling; Mus; Nature; Pathway interactions; Peripheral; Play; Preparation; Process; Property; Research; Retina; Role; Route; Schizophrenia; Slice; Sum; System; Testing; Thalamic Nuclei; Thalamic structure; barrel cortex; cognitive function; cognitive task; design; experimental study; in vivo; neglect; somatosensory

PROJECT SUMMARY The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are critically involved in information flow and functional, dynamic binding between cortical areas via cortico-thalamo-cortical pathways. We propose to study these pathways using the mouse somatosensory system as the model involving both in vitro slice and in vivo whole animal preparations. It appears that, in many and perhaps all cases, cortical areas are connected by both direct and these transthalamic pathways, and we wish to understand why: What is different in the information passed by each pathway? Why does one pass through thalamus with the possibility of being blocked there? Is there nonlinear summation in the target cortical area when both pathways are active, and could this be involved in dynamic linking of areas to subserve various cognitive tasks, such as attention? To begin developing answers to these questions, we propose to probe basic circuit properties of these pathways to better understand the role of the transthalamic pathways in higher cognitive functioning.

项目摘要 拟议的研究将检验与丘脑扮演的迄今忽视的相关假设，并且 在皮质加工中的关键作用。特别是，许多丘脑核共同构成了大多数 丘脑量且以前在功能上是神秘的，我们现在建议与 信息流和功能性，动态结合在皮质区域之间通过皮质 - 甲状腺皮质形成 途径。我们建议使用鼠标体感系统研究这些途径作为涉及的模型 体外切片和整个动物制剂。看来，在许多情况下，所有情况下， 皮质区域都通过直接和这些经过脑丘脑的途径连接，我们希望理解为什么： 每种途径传递的信息中有什么不同？为什么一个人经过丘脑 被阻止的可能性？两种途径时，目标皮质区域是否有非线性求和 有活跃 注意力？为了开始对这些问题的答案，我们建议探究的基本电路属性 这些途径可以更好地了解脑丘脑途径在较高的认知功能中的作用。