Information processing in sensory systems

感觉系统中的信息处理

• 批准号: 7755032
• 负责人: S. Murray SHERMAN
• 金额: $ 31.45万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-08 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7755032
• 关键词: Address; Adopted; Auditory; Auditory area; Auditory system; Automobile Driving; Axon; Brain; Cells; Cellular Morphology; Cognitive; Communication; Data; Dorsal; Electric Stimulation; Feedback; Glutamates; Goals; Hearing; In Vitro; Inferior Colliculus; Injection of therapeutic agent; Label; Lasers; Lead; Leg; Medial geniculate body; Mental Depression; Midbrain structure; Mus; Nature; Neurons; Pathology; Pathway interactions; Pattern; Physiologic pulse; Preparation; Process; Property; Research; Research Personnel; Role; Route; Slice; Staging; Stream; Synapses; System; Techniques; Testing; Thalamic structure; Visual system structure; auditory pathway; biocytin; electrical property; information processing; lexical; novel strategies; object recognition; phonology; programs; research study; selective attention; semantic processing; sensory system; somatosensory

DESCRIPTION (provided by applicant): The broad goal of the proposal is to understand the functional organization of the early thalamocortical stages of processing in the auditory system. This involves a better functional understanding of the various pathways connecting the inferior colliculus (1C), medial geniculate body (MGB), and first and second auditory cortices (Al and All). We will use an in vitro slice preparation of the mouse brain in which different slice configurations will have the 1C to MGB, MGB to AI/AII, Al to MGB, and Al to All pathways intact. We will use uncaging of glutamate by photostimulation or minimal electrical stimulation to test the function of each of the pathways. In particular, we shall attempt to identify each pathway as a driver (i.e., main conveyer of information) or modulator, and by identifying the drivers, we hope to construct a functional hierarchy of information flow. This will allow us to test the hypothesis that a main route of information flow in the system is from the central 1C (ICc) to the ventral portion of MGB (MGBv) to Al to the dorsal MGB (MGBd, which we suggest is a higher order thalamic relay) to All. This is contrasted to conventional views: one is of parallel paths of ICc to MGBv to Al and shell region of 1C (ICs) to MGBd to All; another is a path from ICc to MGBv to Al to All. These hypotheses of functional organization are not mutually exclusive, and combinations may exist. Nonetheless, we must obtain a better understanding of how auditory information is routed through the first few stages of cortical processing before we can begin to understand how pathology in these pathways can lead to problems in hearing. That is, cognitive auditory functions, such as lexical-semantic processing, phonological information extraction, selective attention and object recognition are almost certainly subserved by auditory cortical networks, and it is these networks that we must better understand.

描述（由申请人提供）：该提案的广泛目标是了解听觉系统中处理早期皮层阶段的功能组织。这涉及对连接下丘的各种途径（1C），内侧遗传体（MGB）以及第一和第二听觉皮层（AL和ALL）的各种途径。我们将使用小鼠脑的体外切片制剂，其中不同的切片构型将具有1C至MGB，MGB到AI/AII，AL至MGB，而AL则完整到所有途径。我们将通过光刺激或最小的电刺激对谷氨酸的脱氨酸酯来测试每种途径的功能。特别是，我们将尝试将每种途径识别为驱动程序（即信息的主要输送程序）或调制器，并通过识别驱动程序，希望构建信息流的功能层次结构。这将使我们能够检验以下假设：系统中的主要信息流是从中央1C（ICC）到MGB（MGBV）的腹侧部分到AL到Al到背面MGB（MGBD）（我们建议这是较高阶的丘脑继电器）。这与常规观点形成鲜明对比：一个是ICC到MGBV到Al的平行路径，而1C（ICS）的壳区域到MGBD到所有；另一个是从ICC到MGBV再到AL再到所有人的路径。功能组织的这些假设不是相互排斥的，并且可能存在组合。但是，在我们开始了解这些途径中的病理如何导致听力问题之前，我们必须更好地了解如何通过皮质处理的前几个阶段进行听觉信息。也就是说，认知听觉功能，例如词汇语义处理，语音信息提取，选择性注意力和对象识别，几乎可以肯定是通过听觉皮质网络所提供的，而我们必须更好地理解的是这些网络。