Functional relationships between visual cortex and thalamus

视觉皮层和丘脑之间的功能关系

• 批准号: 9068143
• 负责人: S. Murray SHERMAN
• 金额: $ 46.22万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9068143
• 关键词: Address; Affect; Area; Axon; Back; Behavioral; Blindness; Brain; Cells; Cognitive; Communication; Complement; Data; Defect; Depressed mood; Detection; Disease; Feedback; Feeds; Figs - dietary; Funding; Future; Hand; In Vitro; Individual; Interneurons; Lead; Measures; Mus; Pathology; Pathway interactions; Photic Stimulation; Play; Positioning Attribute; Preparation; Process; Property; Retina; Role; Schizophrenia; Slice; Sorting - Cell Movement; Source; Staging; Synapses; System; Technology; Testing; Thalamic Nuclei; Thalamic structure; Thinking; Vision; Visual; Visual Cortex; Visual Pathways; Visual system structure; Work; area V1; density; design; feeding; gamma-Aminobutyric Acid; in vivo; insight; interest; object recognition; optogenetics; research study; response; selective attention; transmission process; visual information

PROJECT SUMMARY We shall initially use in vitro slice preparations from the mouse brain to study thalamocortical interactions in both directions in the visual system, concentrating on cortical areas V1 and V2 and thalamic nuclei LGN and LP. We then propose to develop in vivo preparations to test hypotheses from the in vitro work. We make heavy use of optogenetics in combination with other stimulation paradigms to activate specific pathways and use both single cell recording and current source density analysis to measure responses. We are particularly interested in the role of the two distinct corticothalamic projections. One emanates from layer 6 and feeds back to the thalamic nucleus innervating that area; we hypothesize that its main function is to depress thalamocortical transmission by multiple complementary mechanisms. The other emanates from layer 5 and is organized in a feed forward fashion, innervating thalamic regions that do not innervate its cortical area; we hypothesize that this represents the initiation of a transthalamic, cortico-thalamo-cortical pathway organized in parallel with direct corticocortical projections. Finally, we shall also test the hypothesis that these dual pathways operate in a coincidence detection manner to control information flow. This could provide more general insights regarding cortical functioning, particularly with respect to new evidence that different cortical areas can dynamically cooperate depending on behavioral needs.

项目摘要 我们最初将使用小鼠脑的体外切片制剂研究丘脑皮质 视觉系统中两个方向的相互作用，集中于皮质区域V1和V2 和丘脑核LGN和LP。然后，我们建议开发体内准备工作以测试 来自体外工作的假设。我们大量使用光遗传学与其他 刺激范式激活特定途径并同时使用单细胞记录和 当前的源密度分析以测量响应。我们对这个角色特别感兴趣 在两个不同的皮质丘脑预测中。一个从第6层散发出来，然后回到 丘脑核支配该区域；我们假设它的主要功能是压抑 丘脑皮质传播通过多种互补机制。其他爆发 从第5层开始，以饲料向前进行组织，使丘脑区域支配 支配其皮质区域；我们假设这代表了脑丘脑的启动， 与直接皮质皮质投影并行组织的皮质 - 丘脑皮层途径。 最后，我们还将检验以下假设：这些双重途径是巧合的 控制信息流的检测方式。这可以提供更多的一般见解 关于皮质功能，特别是关于不同皮质的新证据 区域可以根据行为需求动态合作。