Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

胰腺癌诊断和治疗策略中心

基本信息

批准号：
9904678
负责人：
Sanku Mallik
金额：
$ 176.62万
依托单位：
NORTH DAKOTA STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2022-07-14
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9904678
关键词：
Animal Model Animals Biomedical Research Breast Cancer Center Cancer Death Rates Cancer Etiology Cell model Centers of Research Excellence Cessation of life Collaborations Core Facility Country Data Death Rate Detection Development Diagnosis Diagnostic Disease Early Diagnosis Early treatment Faculty FarGo Funding Goals Grant Health Health Personnel Human Individual Industry Infrastructure Journals Lead Lung Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of pancreas Malignant neoplasm of prostate Mentors Mentorship Mission Nature North Dakota Oncologist Oncology Group Operative Surgical Procedures Pancreas Pilot Projects Publications Publishing Records Research Research Infrastructure Research Personnel Research Project Grants Research Training Resources Series Survival Rate Symptoms Therapeutic Time Training Programs Translational Research Treatment Efficacy United States National Institutes of Health Universities Woman Work anticancer research base cancer type career development cohesion fundamental research graduate student member men multidisciplinary nanoparticle pancreatic cancer patients programs public health relevance recruit research facility symposium tenure track therapy resistant tool trend

项目摘要

DESCRIPTION (provided by applicant): Project Summary (Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early symptoms, short survival, and resistance to therapy are hallmarks of pancreatic vis a vis other forms of cancer. This grim situation calls for the urgent need of effective therapeutic strategies. We are proposing to establish a Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at North Dakota State University (NDSU). This proposed COBRE center will conduct collaborative fundamental studies on developing diagnostic and therapeutic tools which will lead to early detection and treatment of pancreatic cancer. This Center will develop self-sustaining research programs by junior investigators to increase the number of NIH funded research grants, enhance the infrastructure of NDSU to promote biomedical research, and expand the University's capability to establish the disease specific program, particularly on pancreatic cancer. The proposed center will conduct fundamental studies intrinsic to the detection and control of pancreatic cancer at cellular and model animal levels involving a multidisciplinary team of junior investigators. The junior investigators will utilize the resources developed under the proposed Administrative and Animal Cores. The scientific strengths of junior investigators will be synergistically augmented by direct interaction with elite biomedical researchers via direct mentorship and seminar series, and they will become competent to obtain the NIH-R01 grant, leading to the attainment of independent research status. The proposed COBRE center will be instrumental in enhancing the infrastructure of the NDSU campus and support biomedical research. The specific aims of the proposed research are geared toward: (1) developing successful, independent, and self-sustaining research projects engaging junior investigators to increase the number of funded NIH-R01 grants at NDSU, (2) enhancing the infrastructure of NDSU to support biomedical research programs, and (3) establishing a nationally recognized center for pancreatic cancer research at NDSU. These aims will be accomplished by establishing the proposed COBRE center, which will develop diagnostic and therapeutic tools for controlling the onset and proliferation of pancreatic cancer.

描述（由申请人提供）：尽管在各种癌症的检测和治疗方面取得了显着进步，胰腺癌是项目摘要（胰腺癌诊断和治疗策略中心），但胰腺癌是男性和男性和男性和癌症死亡的主要原因之一美国妇女的生存率不到6％。缺乏早期症状，短期生存和对治疗的抵抗是胰腺的标志，患有其他形式的癌症。这种严峻的情况要求迫切需要有效的治疗策略。我们建议在北达科他州立大学（NDSU）建立胰腺癌诊断和治疗策略中心。该拟议的山核桃中心将进行有关开发诊断和治疗工具的合作基础研究，这将导致胰腺癌的早期发现和治疗。该中心将开发初级研究人员自我维持的研究计划，以增加NIH资助的研究补助金的数量，增强NDSU的基础设施以促进生物医学研究，并扩大大学建立特定疾病计划的能力，尤其是在胰腺癌方面。拟议的中心将在涉及涉及初级研究人员的多学科团队的细胞和模型动物水平上对胰腺癌的检测和控制进行固有的基础研究。初级调查人员将利用资源根据拟议的行政和动物核心开发。初级研究者的科学优势将通过直接与精英生物医学研究人员通过直接指导和研讨会系列进行协同增强，并将有能力获得NIH-R01赠款，从而导致获得独立的研究状况。拟议的田园中心将有助于增强NDSU校园的基础设施并支持生物医学研究。拟议研究的具体目的旨在：（1）开发成功，独立和自我维持的研究项目，吸引初级研究人员增加NDSU资助的NIH-R01赠款的数量，（2）加强NDSU的基础设施以增强NDSU的基础设施支持生物医学研究计划，（3）在NDSU建立一个全国认可的胰腺癌研究中心。这些目标将通过建立拟议的毛病中心来实现，该中心将开发诊断和治疗工具来控制胰腺癌的发作和扩散。