Administrative Core: Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

行政核心：胰腺癌诊断和治疗策略中心

• 批准号: 8813059
• 负责人: Sanku Mallik
• 金额: $ 86.74万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813059
• 关键词: Address; Advisory Committees; Ally; Animal Model; Animals; Award; Biomedical Research; Cancer Center; Cell model; Core Facility; Core Grant; Detection; Development Plans; Diagnostic; Discipline of Nursing; Disease; Educational workshop; Ensure; Equilibrium; Equipment; Evaluation; Faculty; Family; Funding; Funding Agency; Goals; Grant; Growth; Institution; Journals; Lead; Leadership; Malignant neoplasm of pancreas; Manuscripts; Mentors; Mission; Monoclonal Antibody R24; North Dakota; Personnel Management; Persons; Pharmacy facility; Pilot Projects; Positioning Attribute; Process; Professional Competence; Publications; Published Comment; Recombinant Proteins; Recommendation; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Scheme; Science; Secure; Strategic Planning; Therapeutic; Time; Training; Translational Research; Travel; United States National Institutes of Health; Universities; Videoconferences; Videoconferencing; Writing; anticancer research; base; career development; college; design; expression cloning; fundamental research; infrastructure development; mathematical sciences; meetings; programs; ranpirnase; research study; success; tenure track; translational study; undergraduate student

__________________________________________________________________________________________ Project Summary (Administrative Core) We are proposing to establish a "Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer" (CDTSPC) in North Dakota State University (NDSU). The Center will conduct fundamental and translational studies devoted to the detection and control of pancreatic cancer at cellular and animal model levels. The goals of this Center are to develop self-sustaining research programs by junior investigators, to increase the number of NIH-funded research grants, to enhance the infrastructure of NDSU to promote biomedical research, and to expand the University's capability to establish the disease specific program particularly on pancreatic cancer. The Administrative Core of the Center will facilitate and ensure that all the components of the Center are functioning efficiently and successfully. The long-term objective of this proposal is to create a flourishing, self- sustaining and internationally-visible center at NDSU for advanced research (fundamental as well as translational) on pancreatic cancer. The proposed center is designed to strengthen the academic roadmaps and strategic plans for the College of Pharmacy, Nursing, and Allied Sciences and the College of Science and Mathematics. These goals will be accomplished through the following Specific Aims. (1) Efficiently and Successfully Direct the Administrative Core. The Administrative Core will provide research support to the junior investigators, and ensure that they have access to the Core Facilities and equipment needed to make rapid progress. The junior investigators will be mentored for cloning, expression and purification of recombinant proteins needed for the proposed projects by the Co-Director, Dr. D. K. Srivastava. The junior investigators will also be provided with training workshops on responsible conduct of research, grant writing, manuscript writing, efficient financial/ personnel management, leadership skills, and career-family balance. We anticipate that these endeavors will cumulatively lead to publications in high impact journals and facilitate the transition of the supported junior investigators to externally funded independent investigators. The Center will conduct formative and summative evaluations of the Administrative Core, junior investigators, the proposed Animal Core Facility, and the mentoring/career development plans. Any weakness noted in these evaluations and other recommendations will be promptly implemented to ensure progress and success of the Center in gaining a self-sustaining status. (2) Develop and implement a result-oriented, tailored Mentoring/Career Development Plan for accelerating the transition of the junior investigators to independently funded investigators. Each junior investigator will have an internal, an external mentor and a tailored mentoring plan for successful graduation to the independent investigator status. The Mentors will provide guidance to junior investigators regarding navigating research problems, future research directions, organization and presentation of manuscripts for high-impact journals, and provide effective strategies for writing successful proposals. The Mentoring/Career Development Plan will be assessed by formative and summative evaluation strategies. (3) Increase the number of biomedical researchers on NDSU campus. This goal will be accomplished by recruiting 4 Pilot Project investigators, 4 Postdoctoral Associates, 2 technicians, 6 graduate and 4 undergraduate students. In addition, NDSU Provost has committed two new tenure-track faculty positions for the proposed Center. We will recruit the faculty during the first and third years to ensure continued growth of the proposed center. As the junior investigators graduate to the independent investigator status, the PIs for the Pilot Project will gain junior investigator status. We will then include new Pilot Projects through a competitive process. (4) Attain a self-sustaining status for the proposed Center. The Director, Co-Director and junior investigators will compete for Institutional Training Grants (T32), Core Grants (P30), Infrastructure Development Grant (R24), and most importantly, Research Project Grants (R01) from NIH and other grants from other funding agencies (federal and non-federal). In order to expand research opportunities, the center will actively collaborate with regional and national institutions focused on pancreatic cancer research. __________________________________________________________________________________________

___________________________________________________________________________________________________ 项目摘要（行政核心） 我们建议建立一个“胰腺癌诊断和治疗策略中心” （CDTSPC）在北达科他州立大学（NDSU）。该中心将进行基本和翻译 专门用于在细胞和动物模型水平上检测和控制胰腺癌的研究。目标 该中心的一个是制定初级调查人员的自我维持研究计划，以增加数量 NIH资助的研究补助金，以增强NDSU的基础设施以促进生物医学研究，并 扩大大学建立特定疾病计划的能力，尤其是胰腺癌。 该中心的行政核心将有助于并确保该中心的所有组件是 有效，成功地运作。该提议的长期目标是创造一个繁荣的自我 NDSU维持和国际可见的中心进行高级研究（基础和 翻译）胰腺癌。拟议的中心旨在加强学术路线图和 药学学院，护理和盟友科学学院以及科学学院的战略计划 数学。这些目标将通过以下特定目标实现。 （1）有效并成功地指导行政核心。行政核心将提供研究 支持初级调查人员，并确保他们可以使用所需的核心设施和设备 快速进步。初级调查人员将指导克隆，表达和纯化 联合导演D. K. Srivastava博士所提出的项目所需的重组蛋白。大三 还将向调查人员提供有关负责任的研究，赠款写作， 手稿写作，有效的财务/人员管理，领导技能和职业家庭平衡。我们 预计这些努力将累积地导致高影响期刊的出版物，并促进 支持的初级调查人员向外部资助的独立研究人员过渡。中心将 拟议的 动物核心设施以及指导/职业发展计划。这些评估中指出的任何弱点 并将迅速实施其他建议，以确保中心的进步和成功 获得自我维持的身份。 （2）制定和实施以结果为导向的，量身定制的指导/职业发展计划，以加速 初级调查人员向独立资助的研究人员的过渡。每个初级调查员都会有一个 内部，外部导师和量身定制的指导计划，成功地毕业至独立 调查员身份。导师将向初级调查人员提供有关导航研究的指导 问题，未来的研究方向，组织和有关高影响期刊的手稿的介绍以及 提供有效的策略来撰写成功的建议。指导/职业发展计划将是 通过形成性和总结性评估策略进行评估。 （3）增加NDSU校园的生物医学研究人员的数量。这个目标将通过 招募4个试点项目调查员，4位博士后伙伴，2名技术人员，6名毕业生和4名本科生 学生。此外，NDSU教务长还为拟议 中心。我们将在第一年和第三年招募教师，以确保拟议中的持续增长 中心。作为初级调查员毕业于独立调查员身份，飞行员项目的PI 将获得初级调查员身份。然后，我们将通过竞争过程包括新的试点项目。 （4）获得拟议中心的自我维持状态。董事，联合导演和初级调查人员将 争夺机构培训补助金（T32），核心补助金（P30），基础设施发展赠款（R24）和 最重要的是，来自NIH的研究项目补助金（R01）和其他资助机构的其他赠款（联邦 和非联邦）。为了扩大研究机会，该中心将与区域和 国家机构专注于胰腺癌研究。 ___________________________________________________________________________________________________