Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer

胰腺癌诊断和治疗策略中心

• 批准号: 8813058
• 负责人: Sanku Mallik
• 金额: $ 206.11万
• 依托单位: NORTH DAKOTA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2021-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8813058
• 关键词: Animal Model; Animals; Biomedical Research; Brain; Breast; Cancer Center; Cancer Death Rates; Cancer Etiology; Cancer Patient; Cell model; Centers of Research Excellence; Cessation of life; Collaborations; Core Facility; Country; Data; Death Rate; Detection; Development; Diagnosis; Diagnostic; Disease; Early Diagnosis; Early treatment; Faculty; FarGo; Funding; Goals; Grant; Health; Health Personnel; Human; Individual; Industry; Journals; Lead; Lung; Malignant Neoplasms; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Mentors; Mentorship; Mission; Nature; North Dakota; Oncologist; Oncology Group; Operative Surgical Procedures; Pancreas; Pilot Projects; Publications; Publishing; Qualifying; Records; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Training; Resources; Series; Staging; Survival Rate; Symptoms; Therapeutic; Time; Training Programs; Translational Research; United States National Institutes of Health; Universities; Woman; Work; anticancer research; base; career development; disorder control; fundamental research; graduate student; member; men; multidisciplinary; nanoparticle; programs; public health relevance; research facility; symposium; tenure track; therapy resistant; tool; trend

 DESCRIPTION (provided by applicant): Project Summary (Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer) In spite of notable advances in detection and treatment of various cancers, pancreatic cancer is one of the leading causes of cancer-related deaths in both men and women in the U.S. with a 5-year survival rate of less than 6%. A lack of early symptoms, short survival, and resistance to therapy are hallmarks of pancreatic vis a vis other forms of cancer. This grim situation calls for the urgent need of effective therapeutic strategies. We are proposing to establish a Center for Diagnostic and Therapeutic Strategies in Pancreatic Cancer at North Dakota State University (NDSU). This proposed COBRE center will conduct collaborative fundamental studies on developing diagnostic and therapeutic tools which will lead to early detection and treatment of pancreatic cancer. This Center will develop self-sustaining research programs by junior investigators to increase the number of NIH funded research grants, enhance the infrastructure of NDSU to promote biomedical research, and expand the University's capability to establish the disease specific program, particularly on pancreatic cancer. The proposed center will conduct fundamental studies intrinsic to the detection and control of pancreatic cancer at cellular and model animal levels involving a multidisciplinary team of junior investigators. The junior investigators will utilize the resources developed under the proposed Administrative and Animal Cores. The scientific strengths of junior investigators will be synergistically augmented by direct interaction with elite biomedical researchers via direct mentorship and seminar series, and they will become competent to obtain the NIH-R01 grant, leading to the attainment of independent research status. The proposed COBRE center will be instrumental in enhancing the infrastructure of the NDSU campus and support biomedical research. The specific aims of the proposed research are geared toward: (1) developing successful, independent, and self-sustaining research projects engaging junior investigators to increase the number of funded NIH-R01 grants at NDSU, (2) enhancing the infrastructure of NDSU to support biomedical research programs, and (3) establishing a nationally recognized center for pancreatic cancer research at NDSU. These aims will be accomplished by establishing the proposed COBRE center, which will develop diagnostic and therapeutic tools for controlling the onset and proliferation of pancreatic cancer.

 描述（由申请人提供）：项目摘要（胰腺癌诊断和治疗策略中心）尽管在各种癌症的检测和治疗方面取得了显着进展，但胰腺癌仍然是男性和女性癌症相关死亡的主要原因之一。美国女性的 5 年生存率低于 6% 与其他类型相比，缺乏早期症状、生存期短和对治疗有抵抗力是胰腺癌的特点。这种严峻的形势迫切需要有效的治疗策略，我们提议在北达科他州立大学 (NDSU) 建立一个胰腺癌诊断和治疗策略中心，该中心将开展胰腺癌的合作基础研究。开发诊断和治疗工具，以实现胰腺癌的早期检测和治疗。该中心将由初级研究人员开发自我维持的研究项目，以增加 NIH 研究经费的资助数量，加强 NDSU 的基础设施，以促进生物医学。研究，并扩大大学建立疾病特定计划的能力，特别是在胰腺癌方面，拟建的中心将由初级研究人员组成的多学科团队在细胞和模型动物水平上进行胰腺癌检测和控制的基础研究。调查人员将利用这些资源 在拟议的行政和动物核心下开发的初级研究人员的科学实力将通过直接指导和研讨会系列与精英生物医学研究人员的直接互动得到协同增强，他们将有能力获得 NIH-R01 资助，从而实现这一目标。拟议的 COBRE 中心将有助于加强 NDSU 校园的基础设施并支持生物医学研究。拟议研究的具体目标是：(1) 发展成功、独立和可靠的研究。吸引初级研究人员参与的自我维持研究项目，以增加 NDSU 资助的 NIH-R01 拨款数量，(2) 加强 NDSU 的基础设施以支持生物医学研究项目，以及 (3) 在 NDSU 建立国家认可的胰腺癌研究中心这些目标将通过建立拟议的 COBRE 中心来实现，该中心将开发用于控制胰腺癌发病和扩散的诊断和治疗工具。