Training in Basic and Translational Digestive Sciences

基础和转化消化科学培训

• 批准号: 9754810
• 负责人: CHUNG OWYANG
• 金额: $ 25.15万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754810
• 关键词: Science; Training

The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists and clinical investigators, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists, was until 2009 continuously funded for 20 years. In 2012 we started a new training program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to eight gastroenterologist physician scientists (all R01 holders), we have expanded our research base to include an additional 17 R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (7), Department of Pathology (3), Department of Cell and Developmental Biology (2), Department of Microbiology and Immunology (2), Division of Infectious Diseases (1), Division of Metabolism, Endocrinology, & Diabetes (1), and Division of Hematology/Oncology (1). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 25 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of obesity and appetite control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation, neoplastic development and programmed cell death. Continued support is requested for 3 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology, and for 3 postdoctoral trainees. The program will be co-directed by Chung Owyang, MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology), and includes coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 25,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the training faculty past and current mentees provide strong evidence that this program will be highly successful in training the next generation of investigators interested in basic and translational digestive sciences.

密歇根大学在过去几个 几十年。自1989年成立以来，我们最初的NIDDK资助培训计划支持了大量 医师科学家和临床研究人员，其中许多人现在保持全职学术职位 美国原始赠款主要是为培训医师科学家而设计的，直到2009年不断 资助20年。 2012年，我们启动了一个新的培训计划，该计划仅着重于培训博士后 （医学博士，博士，医学博士/博士）和对基本和转化消化感兴趣的博士学位候选人科学家 科学。除了八位胃肠病学家医师科学家（所有R01持有人）外，我们还扩展了我们的 研究基础，包括来自部门的另外17名R01资助的基础和医师科学家 病理学系（3），细胞与发育系的分子和综合生理学（7） 生物学（2），微生物和免疫学系（2），传染病科（1），司 代谢，内分泌学和糖尿病（1）和血液学/肿瘤学的分裂（1）。这个程序 合并正在密歇根大学进行胃肠道研究的主要研究人员 医学院成为培训医师科学家和生物医学的强大核心 对基本和转化消化科学感兴趣的研究者。我们组成的25个课程教师都是 自1986年以来，由NIH（P30 DK34933）资助的密歇根州消化疾病核心中心和 带来悠久的协作和团队科学历史。培训计划的重点是三个主题领域 在参与教师之间提供了特殊的跨学科合作：1） 肥胖和食欲控制，内脏疼痛和神经信号调节胃肠道运动； 2）分子和细胞 炎症，组织损伤和修复机制； 3）细胞生长，分化，肿瘤发育 和程序性细胞死亡。要求持续支持3位在其中一家中寻求博士学位的3名毕前训练。 八个学科的范围从生理学到细胞和分子生物学，以及3个博士后学员。这 计划将由医学博士Chung Owyang（胃肠病学系负责）和Bishr共同执导。 Omary，医学博士，博士（生理学主席），包括课程，研讨会，强大的指导和其他 丰富功能。受训者的努力将得到25,000英尺的研究空间的支持，超过 2000万美元的年度NIH研究资金。可用资源的质量和多样性以及 证明了过去和现任培训教师的成功，提供了有力的证据表明 计划将在培训对基本和基本感兴趣的下一代调查人员方面非常成功 翻译消化科学。