Training in Basic and Translational Digestive Sciences

基础和转化消化科学培训

• 批准号: 8481546
• 负责人: CHUNG OWYANG
• 金额: $ 29.16万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8481546
• 关键词: Science; Training

DESCRIPTION (provided by applicant): The University of Michigan has a superb history of training in gastrointestinal sciences over the last several decades. Since its inception in 1989, our original NIDDK-funded training program supported a large number of physician scientists, many of whom now maintain full time academic positions in the U.S. The original grant, which was designed mainly to train physician scientists was until recently continuously funded for 20 years. We now have developed a new program that focuses solely on training postdoctoral (MD, PhD, MD/PhD) and predoctoral PhD candidate scientists interested in basic and translational digestive sciences. In addition to seven astroenterologist physician scientists (Owyang, Merchant, Wiley, Kao, Todisco, Zimmermann, Wang, all R01 holders), we have expanded our research base to include an additional nine R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (Omary, Rui, Samuelson, Shah, Williams), Department of Pathology (Nunez), Department of Cell and Developmental Biology (Gumucio), Division of Infectious Diseases (Young) and Division of Metabolism, Endocrinology, & Diabetes (Myers). This program consolidates the major investigators who are conducting gastrointestinal research at the University of Michigan Medical School into a strong core of mentors for the training of physician scientists and biomedical investigators interested in basic and translational digestive sciences. Our group of 16 program faculty are all members of the Michigan Digestive Diseases Core Center funded by NIH (P30 DK34933) since 1986, and bring a long history of collaboration and team science. The training program focuses on three thematic areas that provide exceptional cross-disciplinary collaboration amongst the participating faculty: 1) neurobiology of peptide control, visceral pain and neurosignaling regulating GI motility; 2) molecular and cellular mechanisms of inflammation, tissue injury and repair; 3) cell growth, differentiation and programmed cell death. Support is requested for 4 predoctoral trainees seeking PhDs in one of eight disciplines that range from Physiology to Cell and Molecular Biology and for 4 postdoctoral trainees. The program will be co-directed by Chung Owyang , MD (Chief of the Division of Gastroenterology) and Bishr Omary, MD, PhD (Chair of Physiology) and includes unique coursework, seminars, strong mentoring and other enriching features. The efforts of the trainees will be supported by 20,000 ft2 of research space and more than $20 million of annual NIH research funding. The combined mass and diversity of available resources and the demonstrated successes of the faculty's prior trainees provide tangible evidence that this program will be successful in training the next generation of investigators interested in basi and translational digestive sciences.

描述（由申请人提供）：在过去的几十年中，密歇根大学拥有胃肠道科学培训的出色史。自1989年成立以来，我们最初由NIDDK资助的培训计划支持了许多医师科学家，其中许多人现在在美国维持全职学术职位，原始赠款主要是为了培训医师科学家，直到最近才继续资助了20年。现在，我们已经开发了一个新计划，该计划仅着眼于培训博士后（MD，PhD，MD/PhD）和对基础和转化消化科学感兴趣的博士学位候选科学家。 In addition to seven astroenterologist physician scientists (Owyang, Merchant, Wiley, Kao, Todisco, Zimmermann, Wang, all R01 holders), we have expanded our research base to include an additional nine R01-funded basic and physician scientists from the Department of Molecular and Integrative Physiology (Omary, Rui, Samuelson, Shah, Williams), Department of Pathology （Nunez），细胞和发育生物学系（Gumucio），传染病（Young）和代谢，内分泌学和糖尿病（Myers）的划分。该计划整合了正在密歇根大学医学院进行胃肠道研究的主要研究人员，成为了对医师科学家和生物医学研究人员培训对基本和翻译感兴趣的培训的强大核心 消化科学。我们的16个课程教职员工都是密歇根州消化疾病核心中心的成员，该中心自1986年以来由NIH（P30 DK34933）资助，并带来了悠久的协作和团队科学历史。该培训计划的重点是三个主题领域，这些领域在参与教师之间提供了特殊的跨学科合作：1）肽控制，内脏疼痛和神经信号的神经生物学调节GI运动； 2）炎症，组织损伤和修复的分子和细胞机制； 3）细胞生长，分化和程序性细胞死亡。要求在八个学科之一中寻求博士学位的4位学员的支持。该计划将由医学博士Chung Owyang（胃肠病学系负责人）和医学博士Bishr Omary（生理学主席）共同执导，其中包括独特的课程工作，研讨会，强大的指导和其他丰富功能。学员的努力将得到20,000英尺的研究领域的支持，并超过2000万美元的NIH研究资金。可用资源的总体和多样性以及学院先前学员的成功提供了明显的证据，表明该计划将成功培训对BASI和转化消化科学感兴趣的下一代调查人员。