Rural Comorbidity and HIV consequences of Opioid use Research and Treatment Initiative (Rural cohort)

阿片类药物使用研究和治疗计划的农村合并症和艾滋病毒后果（农村队列）

• 批准号: 9882992
• 负责人: Heidi M. Crane
• 金额: $ 75.4万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9882992
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Alcohol or Other Drugs use; Area; Behavior assessment; Biometry; Caring; Cities; Clinical; Clinical Data; Clinical Informatics; Clinical Research; Cohort Studies; Collaborations; Collection; Complex; Consequences of HIV; Contracts; Data; Data Collection; Data Linkages; Data Sources; Development; Diagnosis; Disease Outbreaks; Documentation; Ensure; Epidemic; Epidemiologist; Epidemiology; Evidence based practice; Funding; HIV; HIV Infections; HIV risk; HIV/HCV; Harm Reduction; Health; Hepatitis C; Hepatitis C Incidence; Hepatitis C virus; Incidence; Indiana; Individual; Infrastructure; Injecting drug user; Intervention; Intuition; Knowledge; Lead; Leadership; Link; Longitudinal Studies; Measurement; Medicine; Methodology; Methods; National Institute of Drug Abuse; North America; Observational Study; Opioid; Outcome; Outcomes Research; Overdose; Patient Outcomes Assessments; Pharmaceutical Preparations; Population; Population Heterogeneity; Positioning Attribute; Psychometrics; Public Health; Publications; Research; Research Design; Research Personnel; Resources; Risk; Rural; Rural Community; Rural Population; Sample Size; Sampling; Site; Social Network; Subgroup; Substance Use Disorder; System; Target Populations; Testing; United States; United States National Institutes of Health; Vulnerable Populations; Work; addiction; adjudication; behavioral outcome; care systems; clinical epidemiology; clinical research site; clinically relevant; cohort; comorbidity; data centers; data harmonization; data integration; data standards; data tools; experience; heroin use; high risk sexual behavior; improved; innovation; large datasets; meetings; member; method development; multidisciplinary; novel; opioid epidemic; opioid injection; opioid use; opioid use disorder; prevent; prevention service; protocol development; repository; research study; response; rural area; rural setting; screening; tool; tool development; transmission process; web site

The purpose of the Rural Comorbidity and HIV consequences of Opioid use Research and Treatment Initiative (Rural Cohort) Coordinating Center (CC) is to coordinate and support a cohort collaboration of NIH funded studies as they conduct assessments and implement evidence-based practices to address opioid use, HIV and related comorbidities in their rural communities. The overarching purpose is to improve the overall health and outcomes of this vulnerable population. There is also an opportunity to increase the use of HIV prevention and care services and address opioid use in ways that are likely to reduce HIV incidence and prevent new HIV epidemics among substance users. Achieving these objectives will require a CC experienced in data harmonization, multi-site coordination, and research on substance use interventions and impact among substance using populations with and without HIV to comprehensively integrate clinical research data from multiple studies. The resulting large resource of comprehensively integrated clinical data from multiple studies will give researchers the potential to address important scientific and public health questions related to substance use and HIV prevention and outcomes among persons who inject drugs (PWID) that would not be possible with smaller studies. As the Rural Cohort CC, we will work with sites to allow complex, careful, and complete analysis of outcomes and results over many diverse populations using harmonized data from across sites. This will improve the statistical power to identify areas or sub-groups for research focus and to understand what interventions are proving successful in the broader context of the whole population of rural PWID (as opposed to in the target population of a single member site). Careful data harmonization will be paired with intuitive delivery tools to ensure that this high-quality data is made widely available to the member sites. The Rural Cohort CC team brings vast experience with data linkage and harmonization, methods development, statistical support for observational research, platform and tool development such as for the efficient and accurate collection of patient reported outcomes and outcomes adjudication, providing overall coordination for large collaborations of cohorts and studies, and a strong background in clinical epidemiology of HIV and substance use. This will allow us to assist the studies to improve and enhance data collection where appropriate, merge and harmonize data when feasible, and work together more closely to address the key questions on substance use, HIV, and outcomes in rural settings that cannot be addressed by individual studies.

阿片类药物使用研究和治疗计划的农村合并症和艾滋病毒后果的目的 （农村队列）协调中心（CC）是协调和支持NIH资助的队列合作 他们进行评估并实施基于证据的实践来解决阿片类药物的使用，艾滋病毒和 农村社区的相关合并症。总体目的是改善整体健康和 这个脆弱人群的结果。也有机会增加预防艾滋病毒的使用和 护理服务和解决阿片类药物的使用方式可能会减少艾滋病毒的发病率并防止新的艾滋病毒 药物用户的流行。实现这些目标将需要数据中经验丰富的CC 协调，多站点协调以及对物质使用干预措施的研究以及影响 使用有或没有艾滋病毒的种群的物质来全面整合 多个研究。从多个研究中全面整合临床数据的大量资源 将使研究人员有潜力解决与 注射药物（PWID）的人的药物使用和艾滋病毒预防和结果不会 通过较小的研究可能。作为农村队列CC，我们将与网站合作，以允许复杂，谨慎和 使用来自跨越的统一数据对许多不同种群的结果和结果进行完整分析 站点。这将提高统计能力，以确定研究重点的领域或子组和 了解在整个农村人口的更广泛背景下，哪些干预措施证明了什么干预措施 PWID（与单个成员站点的目标人群相反）。仔细的数据协调将是 与直观的交付工具配对，以确保将其广泛可供成员使用 站点。农村队列CC团队为数据链接和协调带来了丰富的经验，方法 开发，对观察研究，平台和工具开发的统计支持，例如 有效，准确地收集患者报告的结果和结果裁决，提供总体上 共同协作的人群和研究，以及临床流行病学的强大背景 艾滋病毒和药物使用。这将使我们能够协助研究改进和增强数据收集 在适当的情况下，可行时合并和协调数据，并更加紧密地解决 关于农村环境中药物使用，艾滋病毒和结果的关键问题，这些问题无法由个人解决 研究。