Neuroscience Advanced Predoctoral institutional Training Grant

神经科学高级博士前机构培训补助金

• 批准号: 9309079
• 负责人: Diane Lipscombe
• 金额: $ 18.73万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9309079
• 关键词: Grant; Neurosciences; Training; pre-doctoral

DESCRIPTION (provided by applicant): The central objective of this advanced predoctoral training program in Neuroscience is to produce graduate students with a high level understanding of the theory, practice, and clinical importance of neural dynamics. Students with appropriate background coursework and research interests will be enrolled in this advanced training plan, a subset of 4 students will receive direct funding from this training grant. Deep knowledge of the basic mechanisms underlying neural dynamics is crucial to understand healthy behavior and many of the profound deficits observed in neurological disease. This topic spans almost all levels of neuroscience inquiry: Biophysics determines patterns of action potential firing, which in turn determines the probability of relay between neurons, and ultimately the information that a neural circuit or distributed representation can carry. Brown University has strong expertise across all these levels, ranging from the genetic bases of neural dynamics underlying behavior through the cognitive neuroscientific study of dynamic control of information processing based on high-level goals. Failures in neural dynamics are widely hypothesized to underlie the pathophysiology of maladies such as epilepsy and Parkinson's disease. The directors, Diane Lipscombe and Chris Moore, have complementary expertise ideal for an Advanced Training Plan in neural dynamics. They will receive advice from external and internal advisory groups and from students, to continue to adapt and improve the training plan. The Neural Dynamics training program will be managed and administered within Brown's Graduate Program in Neuroscience. The Neuroscience Graduate program at Brown offers student-centered, high-quality training and the majority of our graduates pursue careers in neuroscience. Students are also exposed to computational, translational, and clinical approaches. Early multi-disciplinary training dovetails well with this specialized advanced training in Neural Dynamics. This Training Program will provide three basic requirements to produce students with strong training in Neural Dynamics: First, a detailed understanding of the state of knowledge and the defining debates in the study of neural dynamics is required, and will be imparted to students in lectures and seminar courses. This training in basic knowledge will be paired with intensive training in experimental practice to teach students basic principles of scientific design of dynamics studies, and in the cutting edge methods used to resolve debates and test hypotheses in the study of neural dynamics. Students will also design their own experiment(s) on a topic in neural dynamics, and then execute these studies in an intensive 9-day practicum at the Marine Biological Laboratory (MBL). Second, a world-class environment of 29 laboratories investigating this topic at Brown is crucial to foster long-term, in-depth predoctoral research on this topic. Third, access to perspectives beyond those of the home institution, and most importantly beyond classical academia itself, will expand students' understanding and perspective on this important topic.

描述（由申请人提供）：这种高级神经科学前培训计划的核心目的是使研究生对神经动态的理论，实践和临床重要性具有高水平的了解。具有适当背景课程和研究兴趣的学生将参加此高级培训计划，其中4个学生将获得该培训补助金的直接资助。对神经动力学基本机制的深入了解对于了解健康的行为以及在神经系统疾病中观察到的许多深刻缺陷至关重要。该主题涵盖了几乎所有级别的神经科学查询：生物物理学决定了动作电势射击模式，这反过来决定了神经元之间继电器的可能性 神经电路或分布式表示可以携带的信息。布朗大学有 在所有这些层面上的强大专业知识，包括基于高级目标的信息处理动态控制的认知神经科学研究，包括神经动力学行为的遗传基础。神经动力学的失败被广泛假设，是癫痫病和帕金森氏病等疾病的病理生理。董事黛安·利普斯科姆（Diane Lipscombe）和克里斯·摩尔（Chris Moore）具有互补的专业知识，非常适合神经动态的高级培训计划。他们将收到外部和内部咨询小组以及学生的建议，以继续适应和改进培训计划。神经动力学培训计划将在布朗的神经科学研究生计划中进行管理和管理。布朗的神经科学研究生课程提供以学生为中心的高质量培训，而我们的大多数毕业生从事神经科学的职业。学生还接触到计算，翻译和临床方法。早期的多学科培训与这种神经动力学专业的高级培训相吻合。该培训计划将提供三个基本要求，以使学生在神经动力学方面接受强有力的培训：首先，需要对知识状态的详细理解以及研究神经动态研究的定义辩论，并将向学生提供讲座和研讨会课程的学生。基础知识中的这种培训将与实验实践中的深入培训相结合，以教学学生的动态研究科学设计的基本原理，以及用于解决神经动力学研究中的辩论和检验假设的尖端方法。学生还将在神经动力学的主题上设计自己的实验，然后在海洋生物实验室（MBL）的9天实践中执行这些研究。其次，在布朗调查此主题的29个实验室的世界一流环境对于培养有关该主题的长期，深入的研究前研究至关重要。第三，访问家庭机构以外的观点，最重要的是，除了古典学术界本身之外，将扩大学生对这个重要话题的理解和观点。