Electronic Cigarettes in Youth with Asthma

患有哮喘的青少年中的电子烟

• 批准号: 9392084
• 负责人: Alayna Pauline Tackett
• 金额: $ 5.06万
• 依托单位: RHODE ISLAND HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-11 至 2018-07-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9392084
• 关键词: Acute; Adolescent; Adrenal Cortex Hormones; Adult; Aerosols; Affect; Age; Area; Asthma; Biological Markers; Characteristics; Child; Childhood; Chronic Disease; Cigarette; Clinical; Confounding Factors (Epidemiology); Consultations; Cotinine; Data; Data Analyses; Data Collection; Deterioration; Devices; Diagnosis; Electronic cigarette; Exhalation; Exposure to; Focus Groups; Goals; Growth; Health; High School Student; Impairment; Individual; Inflammation; Inflammatory; Intervention; Irritants; Knowledge; Literature; Logistic Regressions; Lung; Measures; Methods; Modeling; Morbidity - disease rate; Nicotine; Nitric Oxide; Participant; Pattern; Perception; Population Assessment of Tobacco and Health; Process; Public Health; Publishing; Pulmonary Function Test/Forced Expiratory Volume 1; Qualitative Research; Reporting; Research; Research Methodology; Research Personnel; Research Training; Respiratory physiology; Risk; Salivary; Sampling; Series; Smoke; Smoker; Spirometry; Techniques; Tobacco; Tobacco use; Toxic effect; Training; United States; United States National Institutes of Health; Vulnerable Populations; Youth; adolescent health; aged; airway inflammation; base; career; health data; innovation; junior high school; mortality; novel; peer; portability; pulmonary function; respiratory; respiratory health; response; trend; uptake

Project Title: Electronic Cigarettes in Youth with Asthma Project Summary/ Abstract: Asthma is the most common pediatric chronic illness in the United States, affecting over six million children and adolescents. While it is well established that traditional “combustible” tobacco is an irritant and can initiate asthma exacerbations, little is known about the impact electronic cigarettes (ECs) may have on respiratory health of adolescents with asthma. ECs can look and feel like regular cigarettes but do not contain tobacco, require combustion, or produce smoke. ECs are currently being marketed to adult smokers as an alternative to cigarettes and are increasing in popularity. Alarmingly, use of ECs has tripled over the last two years among adolescents, and some studies estimate that as many as 1 in 5 adolescents aged 15-19 have tried ECs. Recent data indicate that youth with asthma are more likely than their healthy peers to use ECs. Despite these alarming rates of EC uptake among youth with asthma, little is understood about this phenomenon. The current study seeks to identify why youth with asthma may choose to use ECs, how they obtain ECs, and how they perceive the risk of ECs. First, we will characterize patterns of use, sociodemographic characteristics, access, and perceived harm of ECs in youth with asthma using the NIH/FDA Population Assessment of Tobacco and Health (PATH) Wave 1 Study Data. Second, we will use qualitative techniques to characterize reported knowledge of ECs, access, use, and perceived risk among youth with asthma who are current EC users (past 7 days) or have never used ECs in a series of six focus groups (n = 60). Qualitative data analysis will investigate themes associated with perceptions and use of ECs for youth with asthma. Lastly, we will evaluate the association between EC use and markers of respiratory health, including lung function (FEV1, FEV1/FEVC), and inflammation (exhaled nitric oxide; FeNO), in the same sample of 60 youth with asthma who are either current EC users or never-users to investigate potential acute effects of EC use on respiratory/inflammatory biomarkers. We anticipate a negative association between acute respiratory biomarkers (i.e., FEV1, FEV1/FVC, FeNO) and EC use. This innovative study will have both clinical and

项目名称：哮喘青年中的电子烟 项目摘要/摘要： 哮喘是美国最常见的小儿慢性疾病，影响了600万儿童 和青少年。虽然可以很好地确定传统的“可燃”烟草是一种刺激性，并且可以发起 哮喘恶化，对电子卷烟（EC）的影响可能对呼吸道的影响知之甚少 哮喘的青少年健康。 EC可以看起来和感觉像普通的香烟，但不包含烟草， 需要组合或产生烟雾。 EC目前正在向成年吸烟者销售 香烟越来越受欢迎。令人震惊的是，在过去两年中，ECS的使用率增加了两倍 青少年和一些研究估计，多达15-19岁的青少年中多达1个尝试了EC。 最近的数据表明，患有哮喘的青年比健康的同龄人更有可能使用EC。尽管 这些令人震惊的EC吸收率在哮喘的青年中，对此几乎没有理解 现象。当前的研究旨在确定为什么哮喘的青年可能选择使用EC，以及如何使用EC 获得EC，以及他们如何看待EC的风险。首先，我们将表征使用模式， EC在哮喘的青年中使用社会人口统计学特征，访问和感知的危害 NIH/FDA烟草和健康（PATH）WAVE 1研究数据评估。第二，我们会的 使用定性技术来表征报告的ECS知识，访问，使用和感知风险 在患有哮喘的年轻人中，他们是当前的EC用户（过去7天）或从未使用过EC 六个焦点组（n = 60）。定性数据分析将调查与感知相关的主题 并将EC用于哮喘的年轻人。最后，我们将评估EC使用与 呼吸健康的标记，包括肺功能（FEV1，FEV1/FEVC）和炎症（呼出） 一氧化氮； feno），在同一样本中，有60名哮喘的年轻人是当前的EC用户或 从未使用EC使用对呼吸/炎症生物标志物的潜在急性影响。 我们预计急性呼吸生物标志物（即FEV1，FEV1/FVC，FENO）与 EC使用。这项创新的研究将具有临床和