Testing cortisol dysregulation as a mediator between early stress and adolescent cardiovascular health

测试皮质醇失调作为早期压力和青少年心血管健康之间的中介因素

基本信息

批准号：
10213823
负责人：
Jenalee Rae Doom
金额：
$ 14.66万
依托单位：
UNIVERSITY OF DENVER (COLORADO SEMINARY)
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10213823
关键词：
Address Adolescence Adolescent Adolescent obesity Adrenal Glands Adult American Heart Association Amygdaloid structure Area Arterial Fatty Streak Award Behavior Behavior assessment Behavioral Biological Birth Blood Pressure Cardiovascular Diseases Cardiovascular system Cause of Death Child Childhood Chronic Chronic stress Complex Consumption Data Decision Making Detection Development Diet Dietary Practices Dietary intake Eating Eating Behavior Event Food Fright Goals Gold Health Health Psychology Hippocampus (Brain)Hormones Hydrocortisone Hypertension Hypothalamic structure Impairment Individual Inflammation Intervention Knowledge Lead Learning Life Life Cycle Stages Limbic System Link Literature Longitudinal Studies Measurement Measures Mediating Mediator of activation protein Mentorship Metabolic Metabolism Minority Groups Obesity Outcome Overweight Parents Pathway interactions Phenotype Pituitary Gland Population Poverty Prefrontal Cortex Prevalence Process Psychologist Psychosocial Stress Regulation Research Research Personnel Research Training Risk Serum Markers Stress System Systems Development Testing Training United States Universities Work acute stress base biological adaptation to stress cardiometabolism cardiovascular disorder prevention cardiovascular health career cohort early childhood early experience emotional eating experience frontal lobe health disparity high risk hypothalamic-pituitary-adrenal axis improved inflammatory marker maltreatment neural circuit obesogenic psychosocial racial and ethnic relating to nervous system response socioeconomics statistics young adult

项目摘要

PROJECT SUMMARY/ABSTRACT Cardiovascular disease is the leading cause of death in the United States. Psychosocial stress in early childhood has been linked to poorer cardiovascular health, with behavioral and biological alterations as potential mechanisms. One proposed mechanism between early stress and poorer cardiovascular health later in life is dysregulation in cortisol, a hormone that mediates stress responses and regulates metabolism. Cortisol dysregulation can include heightened or blunted cortisol levels, as both have been associated with chronic stress and poor health. A second proposed mechanism is alterations in diet and eating behaviors following early psychosocial stress as acute and chronic stress have been associated with obesogenic diet and eating behaviors. It is currently unknown whether cortisol dysregulation and altered diet and eating behaviors mediate the association between early psychosocial stress and poorer cardiovascular health in adolescence. The goal of this project is to understand whether cortisol dysregulation and altered diet and eating behaviors are pathways between early childhood stress and poorer cardiovascular health in adolescence. This work will identify targets for interventions to promote ideal cardiovascular health in populations who have experienced early stress. This goal will be accomplished using two complementary cohorts: new data collected on 100 diverse adolescents oversampled for high psychosocial risk and existing data from the Avon Longitudinal Study of Parents and Children (ALSPAC; N=9,600). These cohorts will be used to address two aims. Aim 1: To test the hypothesis that cortisol dysregulation mediates the association between psychosocial stress in early childhood and 1a) adolescent obesity, blood pressure, and serum markers of inflammation and poor cardiovascular health, and 1b) adolescent obesogenic dietary patterns and eating behaviors. Aim 2: To test the hypothesis that childhood obesogenic dietary patterns and eating behaviors mediates the association between psychosocial stress in early childhood and 2a) adolescent obesity, blood pressure, and serum markers of inflammation and poor cardiovascular health, and 2b) adolescent obesogenic dietary patterns and eating behaviors. I am a developmental psychologist with expertise in childhood psychosocial stress and cortisol regulation. This award will enable me to extend my expertise to assessing and improving cardiovascular health in adolescents. To conduct this research, I will complete a training plan based at the University of Denver under the primary mentorship of Dr. Elysia Davis. I will obtain training and content knowledge in the following areas: 1) cardiovascular health and gold-standard approaches for measurement of obesity, blood pressure, and serum markers of cardiovascular health; 2) diet and eating behavior assessment; 3) advanced statistics; and 4) conducting interventions. The research and training in this proposal will help me launch an independent career investigating pathways from early stress to cardiovascular health.

项目概要/摘要心血管疾病是美国的首要死因。早期社会心理压力童年时期与较差的心血管健康有关，行为和生物的改变潜在的机制。一种提出的早期压力与后来心血管健康状况较差之间的机制生活中的一个问题是皮质醇的失调，皮质醇是一种介导压力反应和调节新陈代谢的激素。皮质醇失调可能包括皮质醇水平升高或减弱，因为两者都与慢性压力和健康状况不佳。第二个提出的机制是饮食和饮食行为的改变由于急性和慢性压力与肥胖饮食有关，因此早期心理社会压力之后饮食行为。目前尚不清楚皮质醇失调是否会导致饮食和饮食行为改变介导早期社会心理压力与青春期心血管健康状况较差之间的关联。该项目的目标是了解皮质醇失调是否会导致饮食和饮食行为改变是幼儿期压力与青春期心血管健康状况较差之间的途径。这项工作将确定干预措施的目标，以促进患有以下疾病的人群实现理想的心血管健康早期的压力。这一目标将通过两个互补的队列来实现：收集的新数据 100 不同的青少年因高心理社会风险而过度抽样，以及雅芳纵向调查的现有数据父母和儿童研究（ALSPAC；N=9,600）。这些队列将用于实现两个目标。目标 1：检验皮质醇失调介导心理社会压力之间关联的假设幼儿期和 1a) 青少年肥胖、血压和炎症的血清标志物和不良心血管健康，以及 1b) 青少年肥胖饮食模式和饮食行为。目标 2：测试儿童肥胖饮食模式和饮食行为介导这种关联的假设幼儿期心理社会压力与 2a) 青少年肥胖、血压和血清之间的关系炎症和心血管健康状况不佳的标志物，以及 2b) 青少年肥胖的饮食模式和饮食行为。我是一名发展心理学家，在儿童心理社会压力和皮质醇调节。该奖项将使我能够扩展我的专业知识来评估和改进青少年心血管健康。为了进行这项研究，我将根据以下内容完成一个培训计划：丹佛大学，主要导师为 Elysia Davis 博士。我将获得培训和内容以下领域的知识：1）心血管健康和测量心血管健康的金标准方法肥胖、血压和心血管健康的血清标志物； 2）饮食和饮食行为评估； 3）高级统计； 4) 进行干预。本提案中的研究和培训将对我有所帮助开启独立的职业生涯，研究从早期压力到心血管健康的途径。