Iron Deficiency and Adversity in Early Life and Cardiometabolic Risk in Adulthood

生命早期的缺铁和逆境以及成年后的心脏代谢风险

• 批准号: 9405984
• 负责人: Jenalee Rae Doom
• 金额: $ 0.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9405984
• 关键词: Achievement; Address; Adolescence; Adolescent; Adult; Adverse event; Affect; Age-Months; Anemia; Behavior; Behavioral; Blood Pressure; Body Composition; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Caring; Child; Childhood; Cognitive; Data; Developing Countries; Development; Disadvantaged; Educational Status; Emotional; Environment; Event; Family Violence; Fathers; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Goals; Health; Health behavior; Hormonal; Impairment; Individual; Infant; Insulin; Intervention; Iron; Iron deficiency anemia; Knowledge; Leptin; Life; Life Stress; Link; Lipids; Liver diseases; Longevity; Longitudinal Studies; Malnutrition; Measures; Mediating; Mediator of activation protein; Mental Health; Metabolic; Metabolic syndrome; Metabolism; National Research Service Awards; Neurobiology; Nutrient; Obesity; Outcome; Pathway interactions; Policies; Poverty; Preventive Intervention; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Schools; Social Functioning; Statistical Methods; Stress; Stroke; Subgroup; Testing; Time; Training; Waist-Hip Ratio; absorption; adolescent health; blood lipid; cardiometabolic risk; cardiovascular disorder risk; career; cognitive function; cohort; early experience; emerging adult; experience; fasting glucose; ghrelin; health disparity; high risk; infancy; iron deficiency; iron supplementation; low socioeconomic status; maltreatment; maternal depression; mortality; negative affect; negative mood; novel; nutrition; physical conditioning; prevent; programs; public health relevance; social

 DESCRIPTION (provided by applicant): Iron deficiency (ID) is associated with cardiovascular events such as stroke in children and cardiovascular disease (CVD) and all-cause mortality in adulthood. However, it is unknown whether ID in infancy contributes to the development of CVD and metabolic syndrome (cardio-metabolic risk). Studies of developmental effects of early ID demonstrate long-term negative effects on cognitive functioning, behavior, and socio-emotional development. Such changes may affect health behaviors that increase cardio-metabolic risk. Early adversity (e.g., poverty, maltreatment) is linked to higher cardio-metabolic risk and might also operate through similar cognitive, behavioral, and socio-emotional pathways. As ID is more common in low SES and other disadvantaged circumstances, a yet untested hypothesis is that there is a dual burden of having both ID and early adverse experiences that negatively affects functioning and subsequently increases cardio-metabolic risk. The goal of this project is to understand pathways between early ID and adversity and adult cardio-metabolic risk in order to identify targets for prevention and intervention and to detect subgroups at highest risk for disruptions in functioning and cardio-metabolic health. This goal will be accomplished using data from a large longitudinal study (n > 1000) of the effects of ID from infancy to early adulthood (PIs: Betsy Lozoff and Sheila Gahagan). Information on early ID and adversity (SES, life stress, maternal depression, father absence), adolescent cognitive functioning, health behaviors, and mental health, and adult cardio-metabolic risk (BMI, fat mass, blood pressure, blood lipids, hormonal regulators of metabolism) will be utilized. The first aim will test whether there are indirect effects of early ID on adult cardio-metabolic risk through pathways related to adolescent cognitive functioning, health behaviors, and mental health. The second aim will examine whether early adversity affects cardio-metabolic risk through similar or different pathways. The third aim will examine whether the dual burden of ID and adversity further increases cardio-metabolic risk in adulthood through these adolescent pathways. These aims will be accomplished with a training plan emphasizing the neurobiological and behavioral effects of early ID (sponsor Lozoff), childhood influences on cardio-metabolic risk (co-sponsor Gahagan), early adversity (Lozoff and Gahagan), and advanced statistical methods. Completing this research and training will be the first step in the PI's career plan to conduct policy-relevant research on the impact of nutrition and adversity on mental and physical health throughout the lifespan.

 描述（由适用提供）：铁缺乏症（ID）与心血管事件有关，例如儿童中风和心血管疾病（CVD）和成年后的全因死亡率。但是，尚不清楚婴儿期的ID是否有助于CVD和代谢综合征的发展（心脏代谢风险）。对早期ID的发育影响的研究表明，对认知功能，行为和社会情感发展的长期负面影响。这样的变化可能会影响健康行为，从而增加心脏代谢风险。早期广告（例如，贫困，虐待）与更高的心脏代谢风险有关，也可能通过类似的认知，行为和社会情感途径来运作。由于ID在低SES和其他与灾难有关的情况下更为常见，因此尚未测试的假设是，具有ID和早期不良经历的双重燃烧会对功能产生负面影响，并随后增加心脏代谢风险。该项目的目的是了解早期ID与广告与成人心脏代谢风险之间的途径，以确定预防和干预的目标，并检测到功能和心脏代谢健康中干扰风险最高风险的亚组。该目标将使用大量纵向研究（n> 1000）的数据来实现，从婴儿期到成年初（PIS：Betsy Lozoff和Sheila Gahagan）的影响。有关早期ID和广告（SES，生命压力，母亲抑郁，吸收父亲的抑郁症），青少年认知功能，健康行为和心理健康的信息，以及成人心脏单代代谢风险（BMI，脂肪质量，血压，血压，血脂，代谢性的马匹调节剂）。第一个目的将通过与青少年认知功能，健康行为和心理健康有关的途径来测试早期ID对成人心脏代谢风险的间接影响。第二个目标将检查早期广告是否通过类似或不同的途径影响心脏代谢风险。第三个目标将检查ID和广告的双重燃烧是否会通过这些青少年途径在成年期间进一步增加心脏代谢风险。这些目标将通过强调早期ID（赞助商Lozoff）的神经生物学和行为影响的培训计划，对儿童期对心脏代谢风险（共同赞助者Gahagan），早期广告（Lozoff和Gahagan）以及高级统计学方法的影响。完成这项研究和培训将是PI职业生涯计划的第一步，旨在对整个生命周期中的营养和广告对心理和身体健康的影响进行与政策相关的研究。