Iron Deficiency and Adversity in Early Life and Cardiometabolic Risk in Adulthood

生命早期的缺铁和逆境以及成年后的心脏代谢风险

• 批准号: 9405984
• 负责人: Jenalee Rae Doom
• 金额: $ 0.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9405984
• 关键词: Achievement; Address; Adolescence; Adolescent; Adult; Adverse event; Affect; Age-Months; Anemia; Behavior; Behavioral; Blood Pressure; Body Composition; C-reactive protein; Cardiovascular Diseases; Cardiovascular system; Caring; Child; Childhood; Cognitive; Data; Developing Countries; Development; Disadvantaged; Educational Status; Emotional; Environment; Event; Family Violence; Fathers; Fatty Liver; Fatty acid glycerol esters; Functional disorder; Goals; Health; Health behavior; Hormonal; Impairment; Individual; Infant; Insulin; Intervention; Iron; Iron deficiency anemia; Knowledge; Leptin; Life; Life Stress; Link; Lipids; Liver diseases; Longevity; Longitudinal Studies; Malnutrition; Measures; Mediating; Mediator of activation protein; Mental Health; Metabolic; Metabolic syndrome; Metabolism; National Research Service Awards; Neurobiology; Nutrient; Obesity; Outcome; Pathway interactions; Policies; Poverty; Preventive Intervention; Research; Research Personnel; Research Training; Risk; Risk Factors; Role; Schools; Social Functioning; Statistical Methods; Stress; Stroke; Subgroup; Testing; Time; Training; Waist-Hip Ratio; absorption; adolescent health; blood lipid; cardiometabolic risk; cardiovascular disorder risk; career; cognitive function; cohort; early experience; emerging adult; experience; fasting glucose; ghrelin; health disparity; high risk; infancy; iron deficiency; iron supplementation; low socioeconomic status; maltreatment; maternal depression; mortality; negative affect; negative mood; novel; nutrition; physical conditioning; prevent; programs; public health relevance; social

 DESCRIPTION (provided by applicant): Iron deficiency (ID) is associated with cardiovascular events such as stroke in children and cardiovascular disease (CVD) and all-cause mortality in adulthood. However, it is unknown whether ID in infancy contributes to the development of CVD and metabolic syndrome (cardio-metabolic risk). Studies of developmental effects of early ID demonstrate long-term negative effects on cognitive functioning, behavior, and socio-emotional development. Such changes may affect health behaviors that increase cardio-metabolic risk. Early adversity (e.g., poverty, maltreatment) is linked to higher cardio-metabolic risk and might also operate through similar cognitive, behavioral, and socio-emotional pathways. As ID is more common in low SES and other disadvantaged circumstances, a yet untested hypothesis is that there is a dual burden of having both ID and early adverse experiences that negatively affects functioning and subsequently increases cardio-metabolic risk. The goal of this project is to understand pathways between early ID and adversity and adult cardio-metabolic risk in order to identify targets for prevention and intervention and to detect subgroups at highest risk for disruptions in functioning and cardio-metabolic health. This goal will be accomplished using data from a large longitudinal study (n > 1000) of the effects of ID from infancy to early adulthood (PIs: Betsy Lozoff and Sheila Gahagan). Information on early ID and adversity (SES, life stress, maternal depression, father absence), adolescent cognitive functioning, health behaviors, and mental health, and adult cardio-metabolic risk (BMI, fat mass, blood pressure, blood lipids, hormonal regulators of metabolism) will be utilized. The first aim will test whether there are indirect effects of early ID on adult cardio-metabolic risk through pathways related to adolescent cognitive functioning, health behaviors, and mental health. The second aim will examine whether early adversity affects cardio-metabolic risk through similar or different pathways. The third aim will examine whether the dual burden of ID and adversity further increases cardio-metabolic risk in adulthood through these adolescent pathways. These aims will be accomplished with a training plan emphasizing the neurobiological and behavioral effects of early ID (sponsor Lozoff), childhood influences on cardio-metabolic risk (co-sponsor Gahagan), early adversity (Lozoff and Gahagan), and advanced statistical methods. Completing this research and training will be the first step in the PI's career plan to conduct policy-relevant research on the impact of nutrition and adversity on mental and physical health throughout the lifespan.

 描述（由申请人提供）：缺铁 (ID) 与儿童中风和心血管疾病 (CVD) 等心血管事件以及成年期全因死亡率相关。然而，尚不清楚婴儿期缺铁是否会导致缺铁的发生。 CVD 和代谢综合征（心脏代谢风险）。对早期 ID 发育影响的研究表明，这种变化会对认知功能、行为和社会情绪发育产生长期负面影响，从而增加早期心脏代谢风险。逆境（例如贫困、虐待）与较高的心脏代谢风险有关，并且也可能通过类似的认知、行为和社会情感途径发挥作用，因为智力障碍在低社会经济地位和其他不利环境中更为常见，因此一个尚未得到检验的假设是。智力障碍和早期不良经历会带来双重负担，会对功能产生负面影响，从而增加心脏代谢风险。该项目的目标是了解早期智力障碍和逆境以及成人心脏代谢风险之间的途径。确定预防和干预的目标，并检测功能和心脏代谢健康受损风险最高的亚组。这一目标将利用一项关于 ID 从婴儿期到早期的影响的大型纵向研究（n > 1000）的数据来实现。成年期（PI：Betsy Lozoff 和 Sheila Gahagan）有关早期 ID 和逆境（SES、生活压力、母亲抑郁、父亲缺席）、青少年认知功能、健康行为和心理健康以及成人的信息。将利用心脏代谢风险（BMI、脂肪量、血压、血脂、代谢激素调节剂）。第一个目标将测试早期 ID 是否通过与青少年认知相关的途径对成人心脏代谢风险产生间接影响。第二个目标将尽早研究逆境是否通过类似或不同的途径影响心脏代谢风险。第三个目标将研究智力障碍和逆境的双重负担是否会通过以下方式进一步增加成年期的心脏代谢风险。这些这些目标将通过强调早期智力障碍的神经生物学和行为影响（发起人 Lozoff）、童年对心脏代谢风险（共同发起人 Gahagan）、早期逆境（Lozoff 和 Gahagan）以及晚期的影响的培训计划来实现。完成这项研究和培训将是 PI 职业计划的第一步，旨在就营养和逆境对身心健康的影响进行政策相关研究。整个生命周期。