Respiratory effects of e-cigarette use among youth: a prospective, longitudinal investigation

青少年使用电子烟对呼吸系统的影响：前瞻性纵向调查

基本信息

批准号：
10287431
负责人：
Alayna Pauline Tackett
金额：
$ 19.68万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-17 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10287431
关键词：
Acute Address Adolescence Adolescent Adult Age Airway Resistance American Area Asthma Automobile Driving Behavior Chest Chronic Obstructive Airway Disease Cross-Sectional Studies Data Development Devices Dose Ecological momentary assessment Electronic cigarette Environment Exhalation Frequencies Funding Health High School Student Home environment Impairment Inflammation Inhalation Investigation JUUL Knowledge Laboratories Link Longitudinal Studies Lung Lung diseases Measurement Measures Mentorship Methodology Monitor Nicotine Nicotine Dependence Nitric Oxide Outcome Participant Patient Self-Report Pattern Perception Peripheral Persons Population Assessment of Tobacco and Health Postdoctoral Fellow Prevalence Regulation Reporting Research Research Personnel Resistance Respiratory physiology Role Sampling Smoker Societies Spirometry Time Tobacco Tobacco use Training United States National Institutes of Health Visit Youth base design electric impedance electronic cigarette use electronic cigarette user high school innovation longitudinal design novel polytobacco use prospective pulmonary function respiratory respiratory health response skills tobacco prevention tobacco products tobacco regulatory science tobacco user vaping

项目摘要

PROJECT ABSTRACT Electronic cigarettes (EC) remain the most commonly used product among high schoolers. Little is known about acute and longitudinal respiratory effects of ECs. This novel study will contribute critical knowledge needed to understand pulmonary functioning and respiratory effects among 150 youth who are exclusive-EC (N = 100) or never-users (N = 50; EC or other tobacco products), using a longitudinal, multimethod design. Youth will complete 5-laboratory assessments to provide a comprehensive assessment of respiratory health (airway reactivity and inflammation; pulmonary functioning). Further, we will incorporate EC user topography to assess the immediate acute effects of EC use on respiratory markers. Two weeks prior to laboratory assessments youth will complete daily EMA and spirometry assessments to examine how the frequency and quantity of EC use impairs acute pulmonary functioning. This Tobacco Regulatory K01 will provide much needed evidence regarding the immediate and longitudinal effects of EC use, while providing valuable training to a promising new investigator from leading experts in the field of tobacco regulatory science.

项目摘要电子烟（EC）仍然是高中生最常用的产品。鲜为人知关于 EC 的急性和纵向呼吸影响。这项新颖的研究将贡献关键知识需要了解 150 名 EC 青少年的肺功能和呼吸系统影响 (N = 100) 或从不使用者 (N = 50；EC 或其他烟草制品)，采用纵向多方法设计。青少年将完成 5 项实验室评估，对呼吸系统健康进行全面评估（气道反应性和炎症；肺功能）。此外，我们将把 EC 用户拓扑纳入评估 EC 使用对呼吸标志物的直接急性影响。实验室前两周评估青少年将完成每日 EMA 和肺活量测定评估，以检查频率和 EC 使用量会损害急性肺功能。本烟草监管 K01 将提供很多需要有关 EC 使用的直接和纵向影响的证据，同时提供有价值的培训来自烟草监管科学领域领先专家的一位有前途的新研究员。