Electronic Cigarettes in Youth with Asthma

患有哮喘的青少年中的电子烟

• 批准号: 9744176
• 负责人: Alayna Pauline Tackett
• 金额: $ 0.94万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-28 至 2020-09-10
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9744176
• 关键词: Electronic; Cigarettes; Youth; Asthma

Project Title: Electronic Cigarettes in Youth with Asthma Project Summary/ Abstract: Asthma is the most common pediatric chronic illness in the United States, affecting over six million children and adolescents. While it is well established that traditional “combustible” tobacco is an irritant and can initiate asthma exacerbations, little is known about the impact electronic cigarettes (ECs) may have on respiratory health of adolescents with asthma. ECs can look and feel like regular cigarettes but do not contain tobacco, require combustion, or produce smoke. ECs are currently being marketed to adult smokers as an alternative to cigarettes and are increasing in popularity. Alarmingly, use of ECs has tripled over the last two years among adolescents, and some studies estimate that as many as 1 in 5 adolescents aged 15-19 have tried ECs. Recent data indicate that youth with asthma are more likely than their healthy peers to use ECs. Despite these alarming rates of EC uptake among youth with asthma, little is understood about this phenomenon. The current study seeks to identify why youth with asthma may choose to use ECs, how they obtain ECs, and how they perceive the risk of ECs. First, we will characterize patterns of use, sociodemographic characteristics, access, and perceived harm of ECs in youth with asthma using the NIH/FDA Population Assessment of Tobacco and Health (PATH) Wave 1 Study Data. Second, we will use qualitative techniques to characterize reported knowledge of ECs, access, use, and perceived risk among youth with asthma who are current EC users (past 7 days) or have never used ECs in a series of six focus groups (n = 60). Qualitative data analysis will investigate themes associated with perceptions and use of ECs for youth with asthma. Lastly, we will evaluate the association between EC use and markers of respiratory health, including lung function (FEV1, FEV1/FEVC), and inflammation (exhaled nitric oxide; FeNO), in the same sample of 60 youth with asthma who are either current EC users or never-users to investigate potential acute effects of EC use on respiratory/inflammatory biomarkers. We anticipate a negative association between acute respiratory biomarkers (i.e., FEV1, FEV1/FVC, FeNO) and EC use. This innovative study will have both clinical and

项目名称：哮喘青年中的电子烟 项目摘要/摘要： 哮喘是美国最常见的小儿慢性疾病，感情超过600万儿童 和青少年。 哮喘恶化，对电子卷烟（EC）的影响可能对呼吸道的影响知之甚少 EC的青少年健康看起来像常规香烟，但不含烟草 需要燃烧或产生烟雾 香烟和越来越受欢迎。 青少年和一些研究估计，多达15-19岁的青少年中多达1个尝试了EC。 最近的数据表明，尽管如此，哮喘的年轻人还是健康的同龄人 这些令人震惊的EC吸收率在哮喘的青年中，对此几乎没有理解 现象。 获得EC，以及如何感知EC的风险。 社交特征，访问和感知的EC对青年人使用您的伤害 NIH/FDA的烟草和健康（PATH）WAVE 1研究数据的评估 使用定性技术来表征报告的EC，访问和感知风险的知识 在患有哮喘的年轻人中，他们是当前的EC用户（过去7天）或从未使用过EC 六个焦点组（n = 60）。 并将EC用于哮喘的年轻人。 呼吸健康，含肺功能（FEV1，FEV1/FEVC）和炎症的标志 一氧化氮; 从未使用使用EC使用对呼吸/炎症生物标志物的潜在急性影响。 我们预计急性呼吸生物标志物（即FEV1，FEV1/FVC，FENO）与 EC使用。