Data Standardizing and Sharing

数据标准化与共享

• 批准号: 9280317
• 负责人: GERWIN SCHALK
• 金额: $ 14.8万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-15 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9280317
• 关键词: Achievement; Address; Animals; Area; Basic Science; Brain; Clinical; Cognitive; Computer software; Country; Data; Data Aggregation; Data Collection; Data Set; Effectiveness; Electrocorticogram; Epilepsy; Goals; Human; Implant; Maps; Medical center; Methods; Monkeys; Neurobiology; Operative Surgical Procedures; Patients; Procedures; Protocols documentation; Published Comment; Research; Role; Scientist; Site; Source; Standardization; Surface; Translational Research; Variant; base; brain surgery; data format; data integrity; data management; experimental study

ABSTRACT Electrocorticography (ECoG) refers to recording from the surface of the brain. ECoG has been used for decades for select clinical purposes — most commonly to identify functional and epileptic brain areas in people with epilepsy — and occasionally for research. The important role of ECoG for basic research long been under-appreciated. Over the past several years, the unique qualities of ECoG have become widely and increasingly recognized by scientists engaged in basic and translational research. The primary sources of human ECoG data are patients with epilepsy patients, who receive subdural implants to map epileptic foci and function prior to invasive brain surgery. Thus, data collection is limited to the 125 class-IV epilepsy centers across the country that perform such surgeries, and to about 5-10 patients in each of these centers per year. Hence, larger-scale human ECoG studies and integration with animal ECoG studies, such as those proposed in this application, require that data are collected at multiple medical centers. However, each of them uses variable data collection protocols, data collection software, data collection hardware, data formats, and methods and procedures to keep track of meta information (e.g., the current cognitive status of the subject or other comments). These variations greatly impede, and in practice often prohibit the conduction of ECoGbased studies across multiple sites. Thus, achievement of the scientific goals of the proposed Center relies considerably on the effectiveness and efficiency of the mechanisms to address or mitigate these issues. The Data Management/Sharing (DMS) Core facilitates data collection, integration and sharing of human and animal electrocorticographic (ECoG) data across participating Center sites and projects. While ECoG data provide enormous opportunities for achieving the scientific goals of the Center, each of the five human ECoG sites (and the one monkey ECoG site) in the Center will provide data from only a few subjects each year, and there are important variabilities across subjects and technical setup at each of these sites. Thus, the overarching goal of the DMS Core is to remove or mitigate these variabilities so as to maximize the scientific value of the ECoG datasets produced by the Center and to minimize the difficulty in accessing them. In specific terms, AIM 1 is to provide support for implementation of experiments in standardized software; AIM 2 is to coordinate data collection at ECoG sites using standardized protocols; AIM 3 is to interface with those sites to aggregate data and to verify data integrity; and AIM 4 is to make data available to the Center's four scientific projects using robust and easy-to-use mechanisms.

抽象的 电视仪（ECOG）是指从大脑表面记录。 用于精选临床目的的数十年 - 最常见的是识别人的功能和癫痫大脑区域 癫痫病 - 偶尔进行研究。 在过去的严重程度中，ECOG的独特品质已被广泛接受 越来越多的科学家认识到基本和转化研究。 人类ECOG数据是患有癫痫患者的患者，他们接受次植入物以绘制癫痫灶和 因此，在侵入性脑部手术之前，数据收集限制为125类IV癫痫中心 在全国进行此类手术，每年这些中心中的每个中心中约有5-10名患者。 因此，大规模的人类生态学研究和与动物ECOG研究的整合，例如提议 在此应用程序中，需要在多个医疗中心收集数据。 可变数据收集协议，数据收集软件，数据收集硬件，数据格式 跟踪元信息的方法和程序） 其他评论）。 因此，多个地点的研究。 在解决或减轻这些问题的机制的有效性和效率上很大。 数据管理/共享（DMS）核心促进人类和动物的数据收集，集成和共享 跨参与中心站点和项目的电型（ECOG）数据。 实现中心科学目标的巨大机会，五个人类ECOG （和一个猴子ECOG网站）中心将每年提供几个主题的数据，那里 在每个论文中都是对受试者的重要变化和技术设置。 DMS核心的目标是删除或减轻变化，以最大程度地提高您的科学价值 中心生产的ECOG数据集并以特定术语访问它们的差异。 1是为实现标准化软件的实现提供支持； 使用标准化协议在ECOG站点进行收集； 并验证数据完整性和目标4是为中心提供的科学项目 强大且易于使用的机制。