Assessing vigilance with resting-state fMRI

通过静息态功能磁共振成像评估警惕性

• 批准号: 9317748
• 负责人: THOMAS T LIU
• 金额: $ 23.25万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9317748
• 关键词: Adolescent; Adopted; Brain; Clinical; Clinical Research; Data; Data Set; Disease; Electroencephalography; Functional Magnetic Resonance Imaging; Funding; Goals; Human; Human Activities; Lead; Link; Logistics; Measurement; Measures; Methods; Modality; Performance; Population; Protocols documentation; Public Health; Reporting; Research; Research Personnel; Rest; Sampling; Scanning; Schizophrenia; Signal Transduction; Testing; United States National Institutes of Health; Variant; Wakefulness; Weight; Work; alertness; base; brain health; clinical application; cognitive development; connectome; distributed data; efficacy testing; functional MRI scan; imaging study; improved; research study; signal processing; vigilance

Project Summary Resting-state functional magnetic resonance imaging (rsfMRI) is a leading method for the non-invasive characterization of the functional connectivity and resting-state activity of the human brain. In our prior work we have found that rsfMRI measures of connectivity and signal variance can be significantly altered by the subject's vigilance state. Unless these differences in vigilance are taken into account, differences in connectivity strength and signal variance might be interpreted as a disease-related changes. Currently, electroencephalographic (EEG) measures of brain activity are considered the standard approach for the assessment of vigilance. However, their use in rsfMRI studies is limited due to the technical challenges and logistics involved in obtaining simultaneous rsfMRI and EEG measurements. An alternative approach that does not require the acquisition of EEG data would greatly facilitate the assessment of vigilance in a wide range of rsfMRI studies. The goal of this project is to develop and validate an rsfMRI-based measure of vigilance. The aims of the study are to (1) Develop and optimize rsfMRI-based measures of vigilance levels and fluctuations and (2) Perform a preliminary test of the efficacy of the method in a sample of subjects with schizophrenia.

项目摘要 静止状态功能磁共振成像（RSFMRI）是无创的领先方法 人脑功能连通性和静止状态活性的表征。在我们的先前工作中 我们发现，RSFMRI连通性和信号方差的测量方法可以通过 受试者的警惕状态。除非考虑到这些警惕性的差异，否则 连通性强度和信号方差可能被解释为与疾病相关的变化。现在， 脑活动的脑电图（EEG）测量被认为是该标准方法 警惕评估。但是，由于技术挑战和 涉及获得同时RSFMRI和EEG测量的物流。另一种方法 不需要获取脑电图数据将极大地促进对警惕性的评估 RSFMRI研究。该项目的目的是制定和验证基于RSFMRI的警惕度量。这 该研究的目的是（1）开发和优化基于RSFMRI的警惕水平和波动的度量 （2）对该方法在精神分裂症患者样本中的功效进行初步测试。