Neuroimaging Core

神经影像核心

• 批准号: 7797723
• 负责人: THOMAS T LIU
• 金额: $ 27.81万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7797723
• 关键词: Accounting; Animals; Data; Data Set; Drug usage; Ensure; Functional Magnetic Resonance Imaging; Future; Image; Image Analysis; Literature; Pathway interactions; Perfusion; Procedures; Process; Quality Control; Research Infrastructure; Research Personnel; Resources; Training; Training Activity; Ursidae Family; addiction; blood perfusion; computer infrastructure; computerized data processing; computerized tools; cue reactivity; data acquisition; insight; instrumentation; interest; mind control; neuroimaging; research study

The Neuroimaging Core functions as a resource for instrumentation, data acquisition, processing, and analysis in support of the experiments conducted in Projects 1 and 2. This core will provide cutting edge neuroimaging advances and computational tools, which are important to optimize data processing. The director of this core, Dr. Thomas Liu, is also the Director of the UCSD Center for Functional Magnetic Resonance Imaging (fMRI) and, therefore, brings to bear the significant existing infrastructure of the UCSD Center for fMRI for this proposal. Moreover, Dr. Liu's expertise in perfusion imaging will help provide analysis approaches to determine whether general differences in blood perfusion across groups account for BOLD fMRI differences during the interoception and cue reactivity tasks, and will ensure high quality neuroimaging data. The specific aims of this core are: (1) To utilize neuroimaging procedures developed at the UCSD Center for fMRI to provide continued quality control of ongoing experiments. This aim will help us to optimize our imaging analyses steps and to have explicit quality control implemented similar to that of other large-scale fMRI studies. (2) To provide a core computational infrastructure to standardize and optimize the neuroimaging pipeline. This will help us to compare images obtained for Project 1 with those of Project 2 to better delineate the degree of dysregulated interoception across the addiction cycle. (3) To provide basic and advanced training for all CIDIA associated investigators for neuroimaging acquisition and analysis. This aim is focused primarily on combine educational and training activities in the Neuroimaging Core so as to economize our ability to bring in new investigators, maintain high level of expertise among neuroimaging investigators, and incorporate new insights from the literature to optimize the image analysis pathway. By accomplishing these aims, the core will primarily support Projects 1 and 2, which will make it easier and more appropriate to compare data sets across projects. However, we also envision that this core will begin to explore the possibility for future animal neuroimaging, which could be done in a full center extension of this initial project.

神经成像核心作为仪器，数据采集，处理和 分析支持项目1和2中进行的实验。该核心将提供最先进 神经成像的进步和计算工具，对于优化数据处理非常重要。这 该核心主任托马斯·刘（Thomas Liu）也是UCSD功能磁性中心的主任 共振成像（fMRI），因此带来了UCSD现有的重要基础设施 fMRI中心此提案。此外，刘博士在灌注成像方面的专业知识将有助于提供 分析方法以确定各组的血液灌注的一般差异是否为 大胆的fMRI差异和提示反应性任务的差异，并将确保高质量 神经影像数据。该核心的具体目的是： （1）利用在UCSD fMRI中心开发的神经影像学手术来提供持续的质量 控制正在进行的实验。 这个目标将帮助我们优化成像分析步骤并实施明确的质量控制 类似于其他大型功能磁共振成像研究。 （2）提供核心计算基础架构，以标准化和优化神经影像学管道。 这将帮助我们比较项目1获得的图像与项目2的图像，以更好地描述 整个成瘾周期中的失调互动程度。 （3）为所有CIDIA相关研究者提供基本和高级培训以进行神经影像学 获取和分析。 该目标主要集中于在神经影像核心中结合教育和培训活动，因此 为了节省我们引入新调查人员的能力，保持神经影像之间的高水平专业知识 研究人员，并结合了文献中的新见解，以优化图像分析途径。 通过实现这些目标，核心将主要支持项目1和2，这将使其更容易，并且 更合适地比较跨项目的数据集。但是，我们还设想这个核心将开始 探索未来动物神经影像学的可能性，这可以在完整的中心扩展中进行 这个初始项目。