Federated Database, Protocols, and Tools for Arterial Spin Labeling CBF Measures

用于动脉旋转标记 CBF 测量的联合数据库、协议和工具

• 批准号: 7900870
• 负责人: THOMAS T LIU
• 金额: $ 38.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7900870
• 关键词: AIDS Dementia Complex; Age; Alzheimer' s Disease; Biological Markers; Biomedical Informatics Research Network; Blood; Blood flow; Brain; Cerebrovascular Circulation; Collaborations; Communities; Contrast Media; Core-Binding Factor; Country; Data; Data Quality; Data Set; Data Storage and Retrieval; Databases; Dementia; Dependence; Development; Diagnosis; Disease; Educational process of instructing; Ensure; Environment; Ethnic Origin; Functional Magnetic Resonance Imaging; Funding; Gender; Generations; Glucose; Goals; Health; Human; Image; Institutes; Institution; Lead; Magnetic Resonance Imaging; Measures; Medical; Metabolic; Metadata; Methods; Mining; Oxygen; Performance; Pharmaceutical Preparations; Physiological; Play; Population; Procedures; Process; Protocols documentation; Public Health; Race; Research; Research Infrastructure; Research Personnel; Resources; Role; Sampling; Scanning; Schizophrenia; Shapes; Signal Transduction; Site; Spin Labels; Study Subject; Technical Expertise; Time; United States National Institutes of Health; Work; blood oxygen level dependent; data sharing; experience; federated computing; imaging modality; improved; meetings; novel; prospective; public health relevance; quality assurance; research study; tool

DESCRIPTION (provided by applicant): Cerebral blood flow (CBF) is an important physiological quantity that reflects the delivery of blood to the brain. Measures of CBF can play a critical role in furthering our understanding of how the brain is altered by factors such as disease, age, and medication. In addition, there is a growing appreciation that changes in baseline CBF can significantly alter the amplitude and shape of the blood oxygenation level dependent (BOLD) signal that is measured in most functional magnetic resonance imaging (fMRI) studies of the brain. As a result, a growing number of NIH-funded fMRI studies are obtaining measures of baseline CBF as part of their protocols. These measures are typically obtained using arterial spin labeling (ASL), a magnetic resonance imaging (MRI) method that can provide quantitative measures of CBF in a relatively short amount of time (less than 10 minutes) without the need for external contrast agents. The increasing number of NIH-funded research studies acquiring ASL CBF measures presents a unique opportunity to create a comprehensive database of CBF measures spanning multiple groups and sites. The size and diversity of the combined data would greatly facilitate efforts to extend our understanding of how CBF varies with disease, age, race, ethnic origin, and medical treatment. The overall goal of this project is to create a comprehensive database of CBF measures that will allow investigators to share, analyze, mine, and interpret cerebral blood flow measures from multiple studies and sites. To achieve this goal we propose to build upon the infrastructure of the Biomedical Informatics Research Network (BIRN). The specific aims of the proposal are as follows: (1) Extend the BIRN Data Repository (BDR) to include a shared database of cerebral blood flow measures and associated data from a broad range of studies that are already funded by the NIH or other agencies. This aim will utilize and extend BIRN infrastructure tools, such as the Storage Resource Broker (SRB) for data storage and the Human Imaging Database (HID) environment for the storage, querying, and browsing of subject and image metadata. (2) Standardize protocols and tools for acquisition of ASL data. To ensure the quality of the data submitted to the database, we propose to implement and disseminate a comprehensive set of standardized scan protocols and quality assurance procedures to guide the correct acquisition of the CBF measures and facilitate the analysis and interpretation of the data. PUBLIC HEALTH RELEVANCE: The proposed database will provide investigators across the country with the ability to study how cerebral blood flow varies across a wide range of health conditions and populations. The size and diversity of the database will enable studies that might not otherwise be possible at a single research site. These studies are expected to lead to a better understanding of how measures of cerebral blood flow can advance the diagnosis and treatment of disease.

描述（由申请人提供）：脑血流（CBF）是一个重要的生理量，反映了血液向大脑的递送。 CBF的度量可以在进一步了解大脑如何通过疾病，年龄和药物等因素改变的理解中发挥关键作用。此外，人们越来越多地认识到，基线CBF的变化可以显着改变在大多数大脑的大多数功能磁共振成像（fMRI）研究中测量的血液氧合水平（BOLD）信号的幅度和形状。结果，作为其协议的一部分，越来越多的NIH资助的功能磁共振成像研究正在获得基线CBF的度量。这些度量通常是使用动脉自旋标记（ASL）获得的，这是一种磁共振成像（MRI）方法，可以在相对较短的时间内（小于10分钟）提供CBF的定量度量，而无需外部对比度。 NIH资助的研究越来越多地获取ASL CBF衡量的研究为创建跨越多个组和站点的CBF量度的全面数据库提供了独特的机会。组合数据的规模和多样性将极大地促进我们对CBF如何随疾病，年龄，种族，种族来源和医疗方式变化的努力。该项目的总体目标是创建一个全面的CBF措施数据库，该数据库将允许研究人员共享，分析，矿山和解释来自多个研究和现场的脑血流量测量。为了实现这一目标，我们建议建立生物医学信息学研究网络（BIRN）的基础设施。该提案的具体目的如下：（1）将BIRN数据存储库（BDR）扩展到包含脑血流量测量值的共享数据库以及来自NIH或其他机构已经资助的广泛研究中的相关数据。此目标将利用和扩展BIRN基础架构工具，例如用于数据存储的存储资源经纪（SRB）以及用于存储，查询和浏览主题和图像元数据的人类成像数据库（HID）环境。 （2）标准化用于获取ASL数据的协议和工具。为了确保提交到数据库的数据的质量，我们建议实施和传播一组全面的标准扫描协议和质量保证程序，以指导正确地获取CBF措施，并促进数据的分析和解释。公共卫生相关性：拟议的数据库将为全国各地的调查人员提供研究，能够研究脑血流如何在各种健康状况和人群中变化。数据库的大小和多样性将使在单个研究站点中可能无法实现的研究。预计这些研究将使人们更好地了解脑血流的测量如何推动疾病的诊断和治疗。