PGRN Administrative Coordination Hub, ACH (PGRN)

PGRN 行政协调中心，ACH (PGRN)

• 批准号: 9302796
• 负责人: KATHLEEN M GIACOMINI
• 金额: $ 53.09万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9302796
• 关键词: Access to Information; Address; Administrative Coordination; Area; Clinical; Collaborations; Communication; Communities; Community Networks; Computerized Medical Record; DNA; Data; Development; Disclosure; Disease; Environment; Genes; Genetic; Genomics; Genotype; Goals; Health; Home environment; Human; Incubated; Information Technology; Internet; Interview; Intranet; Japan; Lead; Leadership; Link; Logistics; Medical; Participant; Patients; Pharmaceutical Preparations; Pharmacogenomics; Pharmacotherapy; Phenotype; Publications; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Proposals; Resources; Sampling; Science; Scientific Advances and Accomplishments; Site; Taxes; Technology; Translations; base; biobank; cohort; ethnic diversity; genome-wide; improved; innovation; interest; lectures; meetings; member; news; novel; outreach; phenotypic data; podcast; precision medicine; programs; public health relevance; response; sample collection; success; symposium; virtual; web interface; web site; webinar

 DESCRIPTION (provided by applicant): Our project aims to establish an Administrative Coordination Hub (ACHPGRN) for the new PGRN that will enhance scientific exchange and expand the boundaries of understanding drug response within the context of precision medicine. The ACHPGRN will employ state-of-the art technologies to support PGRN meetings, communications and will build an infrastructure with a public-facing web interface that focuses on recruiting a diverse new membership, encouraging and incubating nascent collaborations, and providing outreach to broader scientific, medical and public communities. The goal of the ACHPGRN is to catalyze communications and collaborations within the PGRN and between the PGRN and the scientific community at large. To achieve this goal, the ACHPGRN will support activities in three main areas. The first area is focused on scientific meetings. The ACHPGRN will provide high quality, reliable logistical support for meetings and webinars to promote scientific exchange focused on precision medicine. The second area centers primarily on the development of a PGRN website to serve as a virtual home that will include TED-style public presentations, monthly news features, publication links, and podcast interviews that continually provide an up-to-date disclosure of PGRN accomplishments. The third area focuses on catalyzing a collaborative, synergistic network by incorporating networking opportunities at our meetings and an innovative Open Proposals platform. This platform allows research proposals to be developed with broad scientific input from the PGRN community. In conjunction with the third area, the ACHPGRN will facilitate opportunities to access large resources that will enable the collaborative research proposals. In particular, the ACHPGRN will facilitate access to enabling resources established by the existing and new PGRN as well as to two large clinical resources that contain phenotypic information on disease and drug response linked to DNA and other samples. BioBank Japan has over 300,000 DNA samples and the Research Program on Genes, Environment and Health, RPGEH, of Kaiser Permanente now includes samples from 100,000 participants with genomewide genotyping data and extensive phenotypic information from the electronic medical record. Collectively, our hub will provide strong support and leadership for a highly interactive and synergistic network that advances scientific discoveries in pharmacogenomics and precision medicine.

 描述（由申请人提供）：我们的项目旨在为新的 PGRN 建立一个行政协调中心 (ACHPGRN)，以加强科学交流并扩大在精准医学背景下理解药物反应的范围。 ACHPGRN 将采用最新技术。 - 支持 PGRN 会议、通信的艺术技术，并将建立一个具有面向公众的网络界面的基础设施，重点是招募多元化的新成员，鼓励和孵化新生合作，并为更广泛的群体提供服务ACHPGRN 的目标是促进 PGRN 内部以及 PGRN 与整个科学界之间的沟通与合作。为了实现这一目标，ACHPGRN 将支持三个主要领域的活动。 ACHPGRN 将为会议和网络研讨会提供高质量、可靠的后勤支持，以促进以精准医学为重点的科学交流。第二个领域主要集中于开发 PGRN 网站作为虚拟主页。其中包括 TED 风格的公开演讲、每月新闻专题、出版物链接和播客采访，不断披露 PGRN 的最新成就。第三个领域的重点是通过在我们的网络机会中促进协作、协同网络。该平台允许通过 PGRN 社区的广泛科学投入来制定研究提案，与第三个领域相结合，ACHPGRN 将提供获取大量资源的机会，从而实现合作研究提案。特别是，ACHPGRN 将促进对现有和新 PGRN 建立的支持资源以及两个大型临床资源的访问，其中包含与 DNA 和其他样本相关的疾病和药物反应的表型信息。日本生物银行拥有超过 300,000 个 DNA 样本和Kaiser Permanente 的基因、环境与健康研究项目 RPGEH 现在包括来自 100,000 名参与者的样本，其中包含来自基因组的基因分型数据和广泛的表型信息总的来说，我们的中心将为一个高度互动和协同的网络提供强有力的支持和领导，推动科学发现。 药物基因组学和精准医学。