Administrative Core

行政核心

• 批准号: 10713241
• 负责人: Kevin J. Staley
• 金额: $ 4.93万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713241
• 关键词: Address; Administrative Coordination; Administrator; Animals; Authorship; Biomedical Engineering; Boston; Brain Injuries; Budgets; Communication; Communities; Consultations; Data; Data Analyses; Data Collection; Data Storage and Retrieval; Discrimination; Documentation; Education; Enrollment; Epileptogenesis; Feedback; Funding; Goals; Grant; Human Resources; Institutional Policy; Intellectual Property; International; Manuscripts; Mathematics; Measures; Microscopy; Monitor; Neocortex; Neurology; Neurosciences; Operating Rooms; Persons; Phase; Policies; Post-Traumatic Epilepsy; Preparation; Professional Organizations; Progress Reports; Publications; Research; Research Personnel; Research Project Grants; Review Committee; Schedule; Scientific Misconduct; Scientist; Series; Structure; Testing; Time; United States National Institutes of Health; Universities; Vendor; Visit; archive data; career; cohort; cost; data archive; data exchange; data management; experimental study; lectures; medical schools; meetings; neocortical; neuropathology; programs; statistics; tool development; virtual

The Administrative Core will coordinate efforts between the Projects and Large Animal and Microscopy Cores. Successful execution of the three projects that comprise this P01 are necessary to test the central hypothesis. Quantification of neocortical network structure (Project 2) and Cl-i and Cl-o (Project 3) must be measured as a function of time after brain injury and epileptogenesis (Project 1). These projects all utilize the same experimental cohort in order to reduce costs and animal usage. Thus close coordination among the projects is essential. Coordination of projects by the Administrative Core greatly facilitates simultaneous data collection and analysis on the same animals. Experiments and animal enrollment are staggered across the duration of the grant to minimize space requirements in the vivarium and operating room and maximize the efficient, continuous utilization of space and personnel. The Administrative Core will coordinate project meetings. Investigators currently meet monthly to review results of Phase I of this project (tool development). We plan to continue these monthly meetings to review progress, address problems, and coordinate research schedules. Coordination by the Administrative Core is described in this section of the proposal. The Administrative core will facilitate the interface of the P01 with external scientists and organizations. In addition to monthly meetings of projects and cores, the Administrative Core will also organize quarterly meetings with the investigators, consultants and the steering committee. At these meetings, the overall direction of the research will be reviewed, manuscripts will be discussed, and presentations at national and international meetings will be addressed. The administrative core will facilitate policy management and the execution of both internal and institutional policies relevant to the project. The administrative core will manage data transfer between projects, data archiving, and access to the data by external investigators. The Administrative Core will coordinate interactions with regulatory agencies, vendors, and professional organizations.

行政核心将协调项目和大型动物和 显微镜核心。构成此 P01 的三个项目的成功执行是 检验中心假设所必需的。新皮质网络结构的量化（项目 2) 以及 Cl-i 和 Cl-o（项目 3）必须作为脑损伤后时间的函数进行测量，并且 癫痫发生（项目 1）。这些项目都利用相同的实验队列，以便 降低成本和动物使用。因此，项目之间的密切协调至关重要。 行政核心对项目的协调极大地促进了同步数据 对同一动物进行收集和分析。实验和动物招募是错开的 在拨款期间最大限度地减少动物园和运营空间的需求 空间和最大限度地有效、连续地利用空间和人员。 行政核心将协调项目会议。调查人员目前每月举行一次会议 审查该项目第一阶段（工具开发）的结果。我们计划继续这些 每月举行一次会议，审查进展、解决问题并协调研究日程。 提案的这一部分描述了行政核心的协调。 行政核心将促进 P01 与外部科学家的接口 组织。除了每月举行的项目和核心会议外，行政核心 还将组织与调查员、顾问和指导人员的季度会议 委员会。在这些会议上，将审查研究的总体方向， 将讨论手稿，并在国内和国际会议上进行演示 已解决。 行政核心将促进政策管理以及内部和外部政策的执行 与项目相关的制度政策。 管理核心将管理项目之间的数据传输、数据归档和访问 外部调查人员的数据。 管理核心将协调与监管机构、供应商和 专业组织。