GENETIC EFFECTS ON ALLERGIES TO ANTIBIOTICS

抗生素过敏的遗传影响

• 批准号: 8363636
• 负责人: KATHLEEN M GIACOMINI
• 金额: $ 1.01万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363636
• 关键词: Antibiotics; Collaborations; Computerized Medical Record; Custom; Funding; Genes; Genetic; Genotype; Grant; Hypersensitivity; Imagery; Informatics; National Center for Research Resources; Patients; Phenotype; Principal Investigator; Research; Research Infrastructure; Resources; Running; Source; United States National Institutes of Health; Variant; allergic response; biocomputing; cost; genome-wide; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. In a collaboration with Affymetrix and Kaiser Permanente, 100,000 patients will be genotyped on custom genomewide genotyping chips focused on medically relevant genes and variation. Electronic medical records will then be accessible to run association studies on various phenotypes of interest. In this case, allergic response to antibiotics will be analyzed.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的首席研究员可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 在与 Affymetrix 和 Kaiser Permanente 的合作中，将使用专注于医学相关基因和变异的定制全基因组基因分型芯片对 100,000 名患者进行基因分型。然后将可以访问电子病历来对各种感兴趣的表型进行关联研究。在这种情况下，将分析对抗生素的过敏反应。