Investigating de novo gene evolution in Drosophila melanogaster

研究果蝇的从头基因进化

• 批准号: 9023562
• 负责人: DAVID J BEGUN
• 金额: $ 41.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9023562
• 关键词: Affinity Chromatography; Biological Process; Code; Data Set; Development; Drosophila genus; Drosophila melanogaster; Evolution; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genomic approach; Genomics; Health; Investigation; Knock-out; Modification; Natural Selections; Population; Proteins; Proteomics; Spermatogenesis; Staging; Testis; Variant; Work; comparative genomics; genomic data; innovation; molecular phenotype; mutant; novel; research study; transcriptome; transcriptomics

Most evolution is the result of modifications of biological function by natural selection. However, truly novel evolutionary innovations are also possible. One example is the recruitment of genes from ancestrally non-genic sequence, which has been described in several species using comparative genomics approaches. Here we focus on the early stages of de novo gene evolution by studying variation and function of such genes segregating in Drosophila melanogaster and fixed since the split with D. simulans.

大多数进化是自然选择改变生物功能的结果。不过确实新颖 进化创新也是可能的。一个例子是从祖先非基因中招募基因 序列，已使用比较基因组学方法在几个物种中进行了描述。在这里我们 通过研究基因的变异和功能来关注基因从头进化的早期阶段 在黑腹果蝇中分离，并在与模拟果蝇分裂后固定。