Investigating de novo gene evolution in Drosophila melanogaster

研究果蝇的从头基因进化

• 批准号: 9023562
• 负责人: DAVID J BEGUN
• 金额: $ 41.67万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-01 至 2019-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9023562
• 关键词: Affinity Chromatography; Biological Process; Code; Data Set; Development; Drosophila genus; Drosophila melanogaster; Evolution; Gene Expression; Genes; Genetic; Genetic Polymorphism; Genomic approach; Genomics; Health; Investigation; Knock-out; Modification; Natural Selections; Population; Proteins; Proteomics; Spermatogenesis; Staging; Testis; Variant; Work; comparative genomics; genomic data; innovation; molecular phenotype; mutant; novel; research study; transcriptome; transcriptomics

Most evolution is the result of modifications of biological function by natural selection. However, truly novel evolutionary innovations are also possible. One example is the recruitment of genes from ancestrally non-genic sequence, which has been described in several species using comparative genomics approaches. Here we focus on the early stages of de novo gene evolution by studying variation and function of such genes segregating in Drosophila melanogaster and fixed since the split with D. simulans.

最多的进化是通过自然选择修饰生物学功能的结果。但是，确实是新颖的 进化创新也是可能的。一个例子是从祖先非基因募集基因 序列，已在几种物种中使用比较基因组学方法进行了描述。我们在这里 通过研究此类基因的变异和功能，重点关注从头基因演变的早期阶段 自与D. simulans分裂以来，在果蝇中分离并固定。