Genomic analysis of adaptation in Drosophila

果蝇适应的基因组分析

• 批准号: 8257528
• 负责人: DAVID J BEGUN
• 金额: $ 29.86万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8257528
• 关键词: Affect; Americas; Australia; Biological Models; Biology; DNA Repair; DNA Sequence; Drosophila genome; Drosophila genus; Drosophila melanogaster; Environment; Equilibrium; Frequencies; Gametogenesis; Genes; Genetic; Genetic Drift; Genetic Models; Genetic Polymorphism; Genetic Variation; Genome; Genomics; Goals; Human; Investigation; Maintenance; Meiosis; Microarray Analysis; Mutation; Phenotype; Population; Population Genetics; Process; Publishing; Recording of previous events; Relative (related person); Research; Sequence Analysis; Technology; Variant; Work; base; comparative; experience; genetic analysis; interest; migration

The exploration of adaptation has been a keystone of evolutionary biology research since Darwin published Origin of Species. Despite this long history of investigation, the genetic basis of adaptation has only recently been studied in a comprehensive manner, primarily because until recently, the necessary genetic and genomic technologies were unavailable. One signature of adaptation in species with high migration rates is genetic differentiation between populations of the same species. In such cases, local selection in different environments is strong enough to overcome the homogenizing force of gene flow. The proposed work seeks to explore the genomics of adaptation along latitudinal clines in the genetic model system, Drosophila melanogaster. The work will use microarray analysis, DNA sequencing, and genetics, to describe variation in genes (and the associated phenotypes) influenced by spatially varying selection in D. melanogaster.

自从适应的探索一直是进化生物学研究的基石 达尔文出版了物种的起源。尽管调查了悠久的历史，但 适应的遗传基础直到最近才以全面的方式研究 主要是因为直到最近，必要的遗传和基因组技术是 不可用。迁移率高的物种适应的一个特征是遗传 区分同一物种的种群。在这种情况下，本地选择 不同的环境足以克服基因的均质力 流动。拟议的工作旨在探索沿纬度的适应基因组学 遗传模型系统中的Clines，果蝇Melanogaster。工作将使用 微阵列分析，DNA测序和遗传学，以描述基因的变异（和 相关的表型）受到黑色素芽孢杆菌的空间不同选择的影响。

项目成果

Parallel Evolution of Copy-Number Variation across Continents in Drosophila melanogaster.

• DOI: 10.1093/molbev/msw014
• 发表时间: 2016-01
• 期刊: Molecular biology and evolution
• 影响因子: 10.7
• 作者: Daniel R. Schrider;Matthew W. Hahn;D. Begun

Functional Analysis of a Putative Target of Spatially Varying Selection in the Menin1 Gene of Drosophila melanogaster.

果蝇 Menin1 基因空间变异选择的假定目标的功能分析。

• DOI: 10.1534/g3.118.200818
• 发表时间: 2019
• 期刊: G3 (Bethesda, Md.)
• 作者: Svetec,Nicolas;Saelao,Perot;Cridland,JulieM;Hoffmann,AryA;Begun,DavidJ
• 通讯作者: Begun,DavidJ

The Adaptive Significance of Natural Genetic Variation in the DNA Damage Response of Drosophila melanogaster.

• DOI: 10.1371/journal.pgen.1005869
• 发表时间: 2016-03
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Svetec N;Cridland JM;Zhao L;Begun DJ
• 通讯作者: Begun DJ

Evidence that natural selection maintains genetic variation for sleep in Drosophila melanogaster.

• DOI: 10.1186/s12862-015-0316-2
• 发表时间: 2015-03-13
• 期刊: BMC evolutionary biology
• 影响因子: 3.4
• 作者: Svetec N;Zhao L;Saelao P;Chiu JC;Begun DJ
• 通讯作者: Begun DJ

Wolbachia do not live by reproductive manipulation alone: infection polymorphism in Drosophila suzukii and D. subpulchrella.

• DOI: 10.1111/mec.12901
• 发表时间: 2014-10
• 期刊: Molecular ecology
• 影响因子: 4.9
• 作者: Hamm CA;Begun DJ;Vo A;Smith CC;Saelao P;Shaver AO;Jaenike J;Turelli M
• 通讯作者: Turelli M