Pre- and Peri-natal Predictors of Childhood Obesity

儿童肥胖的产前和围产期预测因素

基本信息

批准号：
9222311
负责人：
Emily Oken
金额：
$ 102.42万
依托单位：
HARVARD PILGRIM HEALTH CARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-02-06 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9222311
关键词：
11 year old 3 year old Address Adult Affect Age Animal Experiments Animals Atherosclerosis Attention Birth Birth length Blood Blood Pressure Body mass index C-reactive protein Cardiovascular Diseases Cardiovascular system Child Childhood Chronic Disease Cohort Studies Data Diabetes Mellitus Diabetes prevention Diet Dietary intake Dyslipidemias Endocrine Epidemic Fatty Acids Fatty acid glycerol esters Funding Gestational Diabetes Glucose Intolerance Goals Grant Growth Health High Density Lipoprotein Cholesterol Hormones Human Human Development Hypertension Infant Inflammation Insulin Insulin Resistance Insulin-Like Growth Factor I Insulin-Like Growth Factor II Interleukin-6 Knowledge Lead Length Leptin Life Literature Measures Medial Mediating Metabolic Metabolic syndrome Obesity Outcome Pathway interactions Pattern Perinatal Pregnancy Process Public Health Research Risk Factors Roentgen Rays Role Skinfold Thickness Smoking Somatomedins Thick Time Triglycerides Tumor Necrosis Factor Receptor Umbilical Cord Blood Vascular Diseases Vitamin D Weight Weight Gain brachial artery diabetes risk disorder prevention early adolescence endothelial dysfunction fasting glucose gestational weight gain heart disease risk infancy intimal medial thickening maternal cigarette smoking mother nutrition obesity in children obesity prevention prenatal prevent

项目摘要

DESCRIPTION (provided by applicant): As children enter early adolescence, cardiovascular and metabolic consequences of obesity become more apparent. Studies in older children show that obesity and central fat distribution are associated with these outcomes. But how did the children get there in the first place? This is a key question for chronic disease prevention. A now-vast animal experimental literature and a growing human counterpart demonstrate that factors operating at the earliest stages of human development-even before birth-can have lifelong consequences for obesity and cardiometabolic outcomes. Yet major questions still exist regarding how pre- and peri-natal factors operate, through gain in weight and adiposity, to influence these outcomes. In analyses from the previous cycle of "Pre- and peri-natal predictors of childhood obesity, the findings imply both that the endocrine milieu at the time of birth is different from later in life, and that it is likely to be a key driver of weight gain in the first months of life, itself a strong predictor of later obesity and cormorbidities. While these observations are consistent with endocrine knowledge emerging from animal experiments, they raise several questions: 7 To what extent are prenatal factors such as maternal nutrition (e.g., fatty acids, vitamin D), smoking, gestational weight gain, and gestational diabetes associated with perinatal hormone levels? 7 What other hormones are involved in these pathways? In particular, what are the roles of insulin and insulin-like growth factors (IGFs), which are correlated with leptin levels? 7 If these hormones influence childhood weight gain, do they also influence gain in adiposity, fat distribution, components of the metabolic syndrome and vascular dysfunction in early adolescence? 7 To what extent are these influences mediated by adiposity-related inflammation? The overall goal of this renewal of R01 HD 034568-10 is to examine associations of potentially modifiable prenatal factors, hormone levels in umbilical cord blood, gains in weight and adiposity in childhood, adiposity- related inflammation, and cardiometabolic outcomes in early adolescence. including components of the metabolic syndrome, carotid intima-media thickness, and endothelial dysfunction. Extending the productive pre-birth cohort study Project Viva through the age of 11 years provides the opportunity to meet this challenge. The results of this research will lead to new scientific knowledge about the drivers of growth and adiposity in childhood and may very well lead to new avenues for prevention of obesity, diabetes, and cardiovascular disease.

描述（由申请人提供）：随着儿童进入青春期早期，肥胖的心血管和代谢后果变得更加明显。对年龄较大的儿童的研究表明，肥胖和中央脂肪分布与这些结果有关。但是，孩子们是如何首先到达那里的呢？这是预防慢性病的关键问题。如今，一种动物的动物实验文献和不断增长的人类对应物表明，在人类发育的最早阶段运行的因素，即使在出生罐头之前，也会对肥胖和心脏代谢结果产生终生的影响。然而，关于产前和周期因素如何通过体重和肥胖来影响这些结果的主要问题仍然存在。在从上一环的“儿童肥胖预测因素和周期预测指标的分析中，这些发现都暗示，出生时的内分泌环境与生活的后期不同，并且在生命的头几个月中，这是重量的重要驱动力，本身就是后来的肥胖症的强大预测。在多大程度上，诸如母体营养（例如，脂肪酸，维生素D），吸烟，妊娠体重增加和与围产期激素水平相关的妊娠糖尿病是什么？儿童体重增加，它们还会影响青春期早期的肥胖，脂肪分布，代谢综合征的成分和血管功能障碍吗？ 7这些影响在多大程度上是由肥胖相关的炎症介导的？ R01 HD 034568-10续签的总体目标是检查潜在可修改的产前因素的关联，脐带血中的激素水平，童年的体重增加和肥胖性，与脂肪相关的炎症以及早期的心脏代表代谢性表现。包括代谢综合征的成分，颈动脉内膜膜厚度和内皮功能障碍。将生产性的出生前队列研究项目Viva扩展到11岁，这为应对这一挑战提供了机会。这项研究的结果将导致有关儿童生长和肥胖驱动因素的新科学知识，并且很可能会导致预防肥胖，糖尿病和心血管疾病的新途径。